3,3'-Diiodothyronine
Encyclopedia
3,3'-Diiodothyronine is a metabolite of thyroid hormone
.
It is formed from the breakdown of triiodothyronine
. It is an allosteric regulator of the Cytochrome C Oxidase
, the complex IV of the electron transport chain
. It increases its activity by preventing the interaction of ATP
as an allosteric inhibitor.
Levels can be affected in certain disease states.
Thyroid hormone
The thyroid hormones, thyroxine and triiodothyronine , are tyrosine-based hormones produced by the thyroid gland primarily responsible for regulation of metabolism. An important component in the synthesis of thyroid hormones is iodine. The major form of thyroid hormone in the blood is thyroxine ,...
.
It is formed from the breakdown of triiodothyronine
Triiodothyronine
Triiodothyronine, C15H12I3NO4, also known as T3, is a thyroid hormone. It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate....
. It is an allosteric regulator of the Cytochrome C Oxidase
Cytochrome c oxidase
The enzyme cytochrome c oxidase or Complex IV is a large transmembrane protein complex found in bacteria and the mitochondrion.It is the last enzyme in the respiratory electron transport chain of mitochondria located in the mitochondrial membrane...
, the complex IV of the electron transport chain
Electron transport chain
An electron transport chain couples electron transfer between an electron donor and an electron acceptor with the transfer of H+ ions across a membrane. The resulting electrochemical proton gradient is used to generate chemical energy in the form of adenosine triphosphate...
. It increases its activity by preventing the interaction of ATP
Adenosine triphosphate
Adenosine-5'-triphosphate is a multifunctional nucleoside triphosphate used in cells as a coenzyme. It is often called the "molecular unit of currency" of intracellular energy transfer. ATP transports chemical energy within cells for metabolism...
as an allosteric inhibitor.
Levels can be affected in certain disease states.