ABT-724
Encyclopedia
ABT-724 is a drug which acts as a dopamine agonist
, and is selective for the D4 subtype. It was developed as a possible drug for the treatment of erectile dysfunction
, although poor oral bioavailability means alternative drugs such as ABT-670
may be more likely to be developed commercially. Nonetheless, it continues to be used in scientific research into the function of the D4 receptor.
Dopamine agonist
A dopamine agonist is a compound that activates dopamine receptors in the absence of dopamine. Dopamine agonists activate signaling pathways through the dopamine receptor and trimeric G-proteins, ultimately leading to changes in gene transcription.-Uses:...
, and is selective for the D4 subtype. It was developed as a possible drug for the treatment of erectile dysfunction
Erectile dysfunction
Erectile dysfunction is sexual dysfunction characterized by the inability to develop or maintain an erection of the penis during sexual performance....
, although poor oral bioavailability means alternative drugs such as ABT-670
ABT-670
ABT-670 is a drug which acts as a potent, orally bioavailable dopamine agonist selective for the D4 subtype, which was developed as a possible treatment for erectile dysfunction, although its current uses are limited to scientific research.-See also:...
may be more likely to be developed commercially. Nonetheless, it continues to be used in scientific research into the function of the D4 receptor.
See also
- ABT-670ABT-670ABT-670 is a drug which acts as a potent, orally bioavailable dopamine agonist selective for the D4 subtype, which was developed as a possible treatment for erectile dysfunction, although its current uses are limited to scientific research.-See also:...
- BremelanotideBremelanotideBremelanotide is a compound under drug development by Palatin Technologies as a treatment for hemorrhagic shock and reperfusion injury...
- CabergolineCabergolineCabergoline , an ergot derivative, is a potent dopamine receptor agonist on D2 receptors. In vitro, rat studies show cabergoline has a direct inhibitory effect on pituitary lactotroph cells...
- FlibanserinFlibanserinFlibanserin is a drug that was investigated by Boehringer Ingelheim as a novel, non-hormonal treatment for pre-menopausal women with Hypoactive Sexual Desire Disorder . Development was terminated in October 2010 following a negative report by the U.S...
- IntrinsaIntrinsaIntrinsa is a testosterone patch by Procter & Gamble designed to treat Female Sexual Dysfunction .-Background:FSD covers at least four different conditions: problems with desire, arousal, achieving orgasm, and genital pain. The patch aims to increase libido in women...
- Melanotan IIMelanotan IIMelanotan II developed at the University of Arizona is a synthetic analog of the naturally occurring melanocortin peptide hormone alpha-melanocyte stimulating hormone that in usage has been shown to have melanogenesis and aphrodisiac effects in preliminary studies and clinical trials...
- PramipexolePramipexolePramipexole is a non-ergoline dopamine agonist indicated for treating early-stage Parkinson's disease and restless legs syndrome...
- PF-219,061PF-219,061PF-219,061 is a drug developed by Pfizer which acts as a potent and highly selective agonist for the dopamine D3 receptor. It is under development as a potential medication for the treatment of female sexual dysfunction.-See also:* ABT-670* ABT-724...
- TiboloneTiboloneTibolone is a synthetic steroid hormone drug, which is fairly non-selective in its binding profile, acting as an agonist at all five of the Type I steroid hormone receptors. It is used mainly for treatment of endometriosis, as well as hormone replacement therapy in post-menopausal women...
- UK-414,495UK-414,495UK-414,495 is a drug developed by Pfizer for the treatment of female sexual arousal disorder. UK-414,495 acts as a potent, selective inhibitor of the enzyme neutral endopeptidase, which normally serves to break down the neuropeptide VIP...