Alphabetum grandonico-malabaricum sive samscrudonicum is a book on the grammar of the South Indian Malayalam language, published in 1772 at the printing press of the Congregatio de Propaganda Fide in Rome. It is believed to be the first book on Malayalam printed in Europe. The Alphabetum grandonico-malabaricum focuses on the pronunciation of the Malayalam alphabet with many examples in Malayalam characters and includes some remarks on general characteristics of the grammar. At the end, there are also some short Malayalam sentences of a religious nature such as the ten commandments.

The preface was written by Giovanni Cristofano Amaduzzi

Giovanni Cristofano Amaduzzi

Giovanni Cristofano Amaduzzi was a distinguished Italian philologist who flourished during the latter half of the eighteenth century....

, an Italian philologist. The types for the Dravidian script were prepared by Clemente Peani

Clemente Peani

Clemente Peani , also known as Clemens Peanius and Clemens di Gesù, was a member of Congregatio de Propaganda Fide who was involved in the preparation of Alphabetum grandonico-malabaricum sive samscrudonicum, published in 1772 by the congregation's press...

. Amaduzzi supervised the publication of a series of grammars of Oriental languages at the printing press of the Congregatio de Propaganda Fide in Rome. In addition to the Alphabetum grandonico-malabaricum the series comprised, among others, grammars of Burmese, Hindustani, Armenian, Syriac, Arabic, Hebrew, Ethiopic (both Ge'ez and Amharic), Bulgarian etc. Alphabetum grandonico-malabaricum sive samscrudonicum was reprinted several times.