Archibald Hill
Encyclopedia
Archibald Vivian Hill CH
OBE
FRS (26 September 1886 – 3 June 1977) was an English physiologist, one of the founders of the diverse disciplines of biophysics
and operations research
. He shared the 1922 Nobel Prize in Physiology or Medicine
for his elucidation of the production of heat and mechanical work
in muscle
s.
, he was educated at Blundell's School
and graduated from Trinity College, Cambridge
as third wrangler in the mathematics
tripos
before turning to physiology
. His early work involved the characterization of what came to be known as Michaelis-Menten kinetics
and the use of the Hill coefficient. Hill's first paper, published in 1909 while working under the supervision of John Newport Langley
, is a landmark in the history of receptor
theory.
Hill made many exacting measurements of the physics
of nerve
s and muscles. His earliest experiments on the heat production of contracting muscles used equipment obtained from the Swedish physiologist Magnus Blix
. Both before and after World War I
he worked on a range of topics in physiology in cooperation with colleagues in Cambridge, Germany and elsewhere.
Hill is regarded, along with Hermann Helmholtz, as one of the founders of biophysics.
In 1913 he married Margaret Keynes
, daughter of the economist John Neville Keynes
, and sister of the economist John Maynard Keynes
and the surgeon Geoffrey Keynes
. They had two sons and two daughters:
In 1914, at the outbreak of World War I
, Hill joined the British army
and assembled a team working on ballistics
and operations research
. The team included many notable physicist
s including Ralph H. Fowler
, Douglas Hartree
and Arthur Milne
.
Hill returned to Cambridge in 1919 before taking the chair in physiology at the Victoria University of Manchester
in 1920. Parallelling the work of German Otto Fritz Meyerhof
he elucidated the processes whereby mechanical work is produced in muscles. The two shared the 1922 Nobel Prize in Physiology and Medicine for this work.
In 1923 he succeeded Ernest Starling as professor of physiology at University College, London, a post he held until his retirement in 1951. He continued as an active researcher until 1966.
World War II
saw the beginning of Hill's extensive public service. Already in 1935 he was working with Patrick Blackett
and Sir Henry Tizard
on the committee that gave birth to Radar
. In 1933, he became with Lord Beveridge and Lord Rutherford a founder member and vice-president of the Academic Assistance Council
(which became the Society for the Protection of Science and Learning in 1936). By the start of the Second World War, the organization had saved 900 academics (18 of whom went on to win Nobel Prize
s) from the Nazi persecution. He served as an independent
Member of Parliament
(MP) for Cambridge University
from 1940 to 1945. He took part in many scientific missions to the U.S.
Order of the Companions of Honour
The Order of the Companions of Honour is an order of the Commonwealth realms. It was founded by King George V in June 1917, as a reward for outstanding achievements in the arts, literature, music, science, politics, industry or religion....
OBE
Order of the British Empire
The Most Excellent Order of the British Empire is an order of chivalry established on 4 June 1917 by George V of the United Kingdom. The Order comprises five classes in civil and military divisions...
FRS (26 September 1886 – 3 June 1977) was an English physiologist, one of the founders of the diverse disciplines of biophysics
Biophysics
Biophysics is an interdisciplinary science that uses the methods of physical science to study biological systems. Studies included under the branches of biophysics span all levels of biological organization, from the molecular scale to whole organisms and ecosystems...
and operations research
Operations research
Operations research is an interdisciplinary mathematical science that focuses on the effective use of technology by organizations...
. He shared the 1922 Nobel Prize in Physiology or Medicine
Nobel Prize in Physiology or Medicine
The Nobel Prize in Physiology or Medicine administered by the Nobel Foundation, is awarded once a year for outstanding discoveries in the field of life science and medicine. It is one of five Nobel Prizes established in 1895 by Swedish chemist Alfred Nobel, the inventor of dynamite, in his will...
for his elucidation of the production of heat and mechanical work
Mechanical work
In physics, work is a scalar quantity that can be described as the product of a force times the distance through which it acts, and it is called the work of the force. Only the component of a force in the direction of the movement of its point of application does work...
in muscle
Muscle
Muscle is a contractile tissue of animals and is derived from the mesodermal layer of embryonic germ cells. Muscle cells contain contractile filaments that move past each other and change the size of the cell. They are classified as skeletal, cardiac, or smooth muscles. Their function is to...
s.
Biography
Born in BristolBristol
Bristol is a city, unitary authority area and ceremonial county in South West England, with an estimated population of 433,100 for the unitary authority in 2009, and a surrounding Larger Urban Zone with an estimated 1,070,000 residents in 2007...
, he was educated at Blundell's School
Blundell's School
Blundell's School is a co-educational day and boarding independent school located in the town of Tiverton in the county of Devon, England. The school was founded in 1604 by the will of Peter Blundell, one of the richest men in England at the time, and relocated to its present location on the...
and graduated from Trinity College, Cambridge
Trinity College, Cambridge
Trinity College is a constituent college of the University of Cambridge. Trinity has more members than any other college in Cambridge or Oxford, with around 700 undergraduates, 430 graduates, and over 170 Fellows...
as third wrangler in the mathematics
Mathematics
Mathematics is the study of quantity, space, structure, and change. Mathematicians seek out patterns and formulate new conjectures. Mathematicians resolve the truth or falsity of conjectures by mathematical proofs, which are arguments sufficient to convince other mathematicians of their validity...
tripos
Tripos
The University of Cambridge, England, divides the different kinds of honours bachelor's degree by Tripos , plural Triposes. The word has an obscure etymology, but may be traced to the three-legged stool candidates once used to sit on when taking oral examinations...
before turning to physiology
Physiology
Physiology is the science of the function of living systems. This includes how organisms, organ systems, organs, cells, and bio-molecules carry out the chemical or physical functions that exist in a living system. The highest honor awarded in physiology is the Nobel Prize in Physiology or...
. His early work involved the characterization of what came to be known as Michaelis-Menten kinetics
Michaelis-Menten kinetics
In biochemistry, Michaelis–Menten kinetics is one of the simplest and best-known models of enzyme kinetics. It is named after German biochemist Leonor Michaelis and Canadian physician Maud Menten. The model takes the form of an equation describing the rate of enzymatic reactions, by relating...
and the use of the Hill coefficient. Hill's first paper, published in 1909 while working under the supervision of John Newport Langley
John Newport Langley
John Newport Langley was a British physiologist. He spent his entire career at Cambridge University. He was elected a Fellow of the Royal Society in 1883 and later its vice-president....
, is a landmark in the history of receptor
Receptor (biochemistry)
In biochemistry, a receptor is a molecule found on the surface of a cell, which receives specific chemical signals from neighbouring cells or the wider environment within an organism...
theory.
Hill made many exacting measurements of the physics
Physics
Physics is a natural science that involves the study of matter and its motion through spacetime, along with related concepts such as energy and force. More broadly, it is the general analysis of nature, conducted in order to understand how the universe behaves.Physics is one of the oldest academic...
of nerve
Nerve
A peripheral nerve, or simply nerve, is an enclosed, cable-like bundle of peripheral axons . A nerve provides a common pathway for the electrochemical nerve impulses that are transmitted along each of the axons. Nerves are found only in the peripheral nervous system...
s and muscles. His earliest experiments on the heat production of contracting muscles used equipment obtained from the Swedish physiologist Magnus Blix
Magnus Blix
Magnus Gustaf Blix was a Swedish physiologist who was a professor at the universities of Uppsala and Lund....
. Both before and after World War I
World War I
World War I , which was predominantly called the World War or the Great War from its occurrence until 1939, and the First World War or World War I thereafter, was a major war centred in Europe that began on 28 July 1914 and lasted until 11 November 1918...
he worked on a range of topics in physiology in cooperation with colleagues in Cambridge, Germany and elsewhere.
Hill is regarded, along with Hermann Helmholtz, as one of the founders of biophysics.
In 1913 he married Margaret Keynes
Keynes family
The Keynes family is a prominent English family that has included notable economists, writers, and actors.The descendants of Geoffrey Keynes , are also related to the Darwin — Wedgwood family.-Family tree of modern Keynes family:-History:...
, daughter of the economist John Neville Keynes
John Neville Keynes
John Neville Keynes was a British economist and father of John Maynard Keynes.-Biography:Born in Salisbury, he was the son of Dr John Keynes and his wife Anna Maynard Neville . He was educated at Amersham Hall School, University College London and Pembroke College, Cambridge, where he became a...
, and sister of the economist John Maynard Keynes
John Maynard Keynes
John Maynard Keynes, Baron Keynes of Tilton, CB FBA , was a British economist whose ideas have profoundly affected the theory and practice of modern macroeconomics, as well as the economic policies of governments...
and the surgeon Geoffrey Keynes
Geoffrey Keynes
Sir Geoffrey Langdon Keynes was an English biographer, surgeon, physician, scholar and bibliophile...
. They had two sons and two daughters:
- Polly Hill (1914–2005), economist, married K.A.C. Humphreys, registrar of the West African Examinations Council.
- David Keynes HillDavid Keynes HillDavid Keynes Hill FRS was a British biophysicist.Hill was the son of Nobel-prize winning physiologist Archibald Vivian Hill and his wife Margaret Keynes, the daughter of John Neville Keynes and sister of John Maynard Keynes. His sister was economist Polly Hill and his brother the oceanographer...
(1915–2002), physiologist - Maurice Hill (1919–1966), oceanographer
- Janet Hill (1918–2000) child psychiatrist, married the immunologist John Herbert Humphrey.
In 1914, at the outbreak of World War I
World War I
World War I , which was predominantly called the World War or the Great War from its occurrence until 1939, and the First World War or World War I thereafter, was a major war centred in Europe that began on 28 July 1914 and lasted until 11 November 1918...
, Hill joined the British army
British Army
The British Army is the land warfare branch of Her Majesty's Armed Forces in the United Kingdom. It came into being with the unification of the Kingdom of England and Scotland into the Kingdom of Great Britain in 1707. The new British Army incorporated Regiments that had already existed in England...
and assembled a team working on ballistics
Ballistics
Ballistics is the science of mechanics that deals with the flight, behavior, and effects of projectiles, especially bullets, gravity bombs, rockets, or the like; the science or art of designing and accelerating projectiles so as to achieve a desired performance.A ballistic body is a body which is...
and operations research
Operations research
Operations research is an interdisciplinary mathematical science that focuses on the effective use of technology by organizations...
. The team included many notable physicist
Physicist
A physicist is a scientist who studies or practices physics. Physicists study a wide range of physical phenomena in many branches of physics spanning all length scales: from sub-atomic particles of which all ordinary matter is made to the behavior of the material Universe as a whole...
s including Ralph H. Fowler
Ralph H. Fowler
Sir Ralph Howard Fowler OBE FRS was a British physicist and astronomer.-Education:Fowler was initially educated at home but then attended Evans' preparatory school at Horris Hill and Winchester College...
, Douglas Hartree
Douglas Hartree
Douglas Rayner Hartree PhD, FRS was an English mathematician and physicist most famous for the development of numerical analysis and its application to the Hartree-Fock equations of atomic physics and the construction of the meccano differential analyser.-Early life:Douglas Hartree was born in...
and Arthur Milne
Arthur Milne
Edward Arthur Milne FRS was a British astrophysicist and mathematician.- Biography :Milne was born in Hull, Yorkshire, England...
.
Hill returned to Cambridge in 1919 before taking the chair in physiology at the Victoria University of Manchester
Victoria University of Manchester
The Victoria University of Manchester was a university in Manchester, England. On 1 October 2004 it merged with the University of Manchester Institute of Science and Technology to form a new entity, "The University of Manchester".-1851 - 1951:The University was founded in 1851 as Owens College,...
in 1920. Parallelling the work of German Otto Fritz Meyerhof
Otto Fritz Meyerhof
-External links:* *...
he elucidated the processes whereby mechanical work is produced in muscles. The two shared the 1922 Nobel Prize in Physiology and Medicine for this work.
In 1923 he succeeded Ernest Starling as professor of physiology at University College, London, a post he held until his retirement in 1951. He continued as an active researcher until 1966.
World War II
World War II
World War II, or the Second World War , was a global conflict lasting from 1939 to 1945, involving most of the world's nations—including all of the great powers—eventually forming two opposing military alliances: the Allies and the Axis...
saw the beginning of Hill's extensive public service. Already in 1935 he was working with Patrick Blackett
Patrick Blackett, Baron Blackett
Patrick Maynard Stuart Blackett, Baron Blackett OM CH FRS was an English experimental physicist known for his work on cloud chambers, cosmic rays, and paleomagnetism. He also made a major contribution in World War II advising on military strategy and developing Operational Research...
and Sir Henry Tizard
Henry Tizard
Sir Henry Thomas Tizard FRS was an English chemist and inventor and past Rector of Imperial College....
on the committee that gave birth to Radar
Radar
Radar is an object-detection system which uses radio waves to determine the range, altitude, direction, or speed of objects. It can be used to detect aircraft, ships, spacecraft, guided missiles, motor vehicles, weather formations, and terrain. The radar dish or antenna transmits pulses of radio...
. In 1933, he became with Lord Beveridge and Lord Rutherford a founder member and vice-president of the Academic Assistance Council
Council for Assisting Refugee Academics
The Council for Assisting Refugee Academics is a British charitable organization dedicated to assisting academics who, for reasons including persecution and conflict, are unable to continue their research in their countries of origin...
(which became the Society for the Protection of Science and Learning in 1936). By the start of the Second World War, the organization had saved 900 academics (18 of whom went on to win Nobel Prize
Nobel Prize
The Nobel Prizes are annual international awards bestowed by Scandinavian committees in recognition of cultural and scientific advances. The will of the Swedish chemist Alfred Nobel, the inventor of dynamite, established the prizes in 1895...
s) from the Nazi persecution. He served as an independent
Independent (politician)
In politics, an independent or non-party politician is an individual not affiliated to any political party. Independents may hold a centrist viewpoint between those of major political parties, a viewpoint more extreme than any major party, or they may have a viewpoint based on issues that they do...
Member of Parliament
Member of Parliament
A Member of Parliament is a representative of the voters to a :parliament. In many countries with bicameral parliaments, the term applies specifically to members of the lower house, as upper houses often have a different title, such as senate, and thus also have different titles for its members,...
(MP) for Cambridge University
Cambridge University (UK Parliament constituency)
Cambridge University was a university constituency electing two members to the British House of Commons, from 1603 to 1950.-Boundaries, Electorate and Election Systems:...
from 1940 to 1945. He took part in many scientific missions to the U.S.
Honours and awards
- Commander of the Order of the British EmpireOrder of the British EmpireThe Most Excellent Order of the British Empire is an order of chivalry established on 4 June 1917 by George V of the United Kingdom. The Order comprises five classes in civil and military divisions...
(1918) - Fellow of the Royal SocietyRoyal SocietyThe Royal Society of London for Improving Natural Knowledge, known simply as the Royal Society, is a learned society for science, and is possibly the oldest such society in existence. Founded in November 1660, it was granted a Royal Charter by King Charles II as the "Royal Society of London"...
(1918) - Nobel Prize in Physiology or MedicineNobel Prize in Physiology or MedicineThe Nobel Prize in Physiology or Medicine administered by the Nobel Foundation, is awarded once a year for outstanding discoveries in the field of life science and medicine. It is one of five Nobel Prizes established in 1895 by Swedish chemist Alfred Nobel, the inventor of dynamite, in his will...
(1922) - Companion of HonourOrder of the Companions of HonourThe Order of the Companions of Honour is an order of the Commonwealth realms. It was founded by King George V in June 1917, as a reward for outstanding achievements in the arts, literature, music, science, politics, industry or religion....
(1946) - Copley MedalCopley MedalThe Copley Medal is an award given by the Royal Society of London for "outstanding achievements in research in any branch of science, and alternates between the physical sciences and the biological sciences"...
of the Royal Society (1948)