Creola bodies
Encyclopedia
Creola bodies are a histopathologic finding indicative of asthma
. Found in a patient's sputum
, they are ciliated columnar cells sloughed from the bronchial mucosa of a patient with asthma. Other common findings in the sputum of asthma patients include Charcot-Leyden crystals
, Curschmann's Spirals
, and eosinophils (and excessive amounts of sputum).
In a study by Yoshihara et al. 60% of pediatric asthmatic patients demonstrating acute symptoms were found to have creola bodies in their sputum (CB+). These patients had increased levels of neutrophil-mediated cytokine
activity concluding that "epithelial damage is associated with a locally enhanced chemotactic signal for and activity of neutrophils, but not eosinophils, during acute exacerbations of paediatric asthma."
Asthma
Asthma is the common chronic inflammatory disease of the airways characterized by variable and recurring symptoms, reversible airflow obstruction, and bronchospasm. Symptoms include wheezing, coughing, chest tightness, and shortness of breath...
. Found in a patient's sputum
Sputum
Sputum is mucus that is coughed up from the lower airways. It is usually used for microbiological investigations of respiratory infections....
, they are ciliated columnar cells sloughed from the bronchial mucosa of a patient with asthma. Other common findings in the sputum of asthma patients include Charcot-Leyden crystals
Charcot-Leyden crystals
Charcot-Leyden crystals are microscopic crystals found in people who have allergic diseases such as asthma or parasitic infections such as parasitic pneumonia or ascariasis.The Charcot-Leyden crystal protein interacts with eosinophil lysophospholipases....
, Curschmann's Spirals
Curschmann's Spirals
Curschmann's spirals refers to a finding in the sputum of spiral shaped mucus plugs. These may occur in several different lung diseases.The term can refer to parts of the desquamated epithelium seen in biopsies from asthmatic patients. They are named after German physician Heinrich Curschmann...
, and eosinophils (and excessive amounts of sputum).
In a study by Yoshihara et al. 60% of pediatric asthmatic patients demonstrating acute symptoms were found to have creola bodies in their sputum (CB+). These patients had increased levels of neutrophil-mediated cytokine
Cytokine
Cytokines are small cell-signaling protein molecules that are secreted by the glial cells of the nervous system and by numerous cells of the immune system and are a category of signaling molecules used extensively in intercellular communication...
activity concluding that "epithelial damage is associated with a locally enhanced chemotactic signal for and activity of neutrophils, but not eosinophils, during acute exacerbations of paediatric asthma."