FAIRE-Seq is a method in molecular biology

Molecular biology

Molecular biology is the branch of biology that deals with the molecular basis of biological activity. This field overlaps with other areas of biology and chemistry, particularly genetics and biochemistry...

 used for determining the sequences of those DNA regions in the genome associated with regulatory activity. In contrast to DNase-seq

DNase-Seq

DNase-Seq is a method in molecular biology used to identify the location of regulatory regions, based on the genome-wide sequencing of regions super sensitivity to cleavage by DNase I. FAIRE-Seq is a successor of DNase-Seq for the genome-wide identification of accessible DNA regions in the genome....

, the FAIRE-Seq protocol doesn't require the permeabilization of cells or isolation of nuclei, and can analyse any cell types. In a study of seven diverse human cell types, DNase-seq and FAIRE-seq produced strong cross-validation, with each cell type having 1-2% of the human genome as open chromatin .