LEKTI-2
Encyclopedia
Lympho-epithelial Kazal-type related inhibitor 2 (LEKTI-2) is a protein encoded by the SPINK9 gene in humans. LEKTI-2 is an inhibitor of KLK5
, a serine protease
expressed in the epidermis
and responsible for coordinating skin homeostasis
and desquamation
. SPINK9 is a member of a gene family cluster located on chromosome
5q33.1, which includes SPINK5
and SPINK6
.
KLK5
Kallikrein-related peptidase 5 , formerly known as stratum corneum tryptic enzyme , is a serine protease expressed in the epidermis. In humans it is encoded by the KLK5 gene. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is...
, a serine protease
Serine protease
Serine proteases are enzymes that cleave peptide bonds in proteins, in which serine serves as the nucleophilic amino acid at the active site.They are found ubiquitously in both eukaryotes and prokaryotes...
expressed in the epidermis
Epidermis
Epidermis may refer to:* Epidermis , in plants, the outermost layer of cells covering the leaves and young parts of a plant* Epidermis , the outermost layer of the skin of a human...
and responsible for coordinating skin homeostasis
Homeostasis
Homeostasis is the property of a system that regulates its internal environment and tends to maintain a stable, constant condition of properties like temperature or pH...
and desquamation
Desquamation
Desquamation , also called skin peeling, is the shedding of the outermost membrane or layer of a tissue, such as the skin.-Skin:Normal, nonpathologic desquamation of the skin occurs when keratinocytes, after moving apically over about 14 days, are individually shed unnoticeably...
. SPINK9 is a member of a gene family cluster located on chromosome
Chromosome
A chromosome is an organized structure of DNA and protein found in cells. It is a single piece of coiled DNA containing many genes, regulatory elements and other nucleotide sequences. Chromosomes also contain DNA-bound proteins, which serve to package the DNA and control its functions.Chromosomes...
5q33.1, which includes SPINK5
SPINK5
Lympho-epithelial Kazal-type-related inhibitor also known as serine protease inhibitor Kazal-type 5 is a protein that in humans is encoded by the SPINK5 gene.- Structure and function :...
and SPINK6
SPINK6
Serine protease inhibitor Kazal-type 6 is a protein encoded by the SPINK6 gene in humans. It is a potent inhibitor of epidermal proteases involved in maintaining skin homeostasis, including KLK5, KLK7 and KLK14. SPINK6 is a member of a gene family cluster located on chromosome 5q33.1, which...
.