MAM domain is an evolutionary conserved protein domain

Protein domain

A protein domain is a part of protein sequence and structure that can evolve, function, and exist independently of the rest of the protein chain. Each domain forms a compact three-dimensional structure and often can be independently stable and folded. Many proteins consist of several structural...

. It is an extracellular domain found in many receptors.

A 170 amino acid domain, the so-called MAM domain, has been recognised in the extracellular region of functionally diverse proteins. These proteins have a modular, receptor-like architecture comprising a signal peptide, an N-terminal extracellular domain, a single transmembrane domain and an intracellular domain. Such proteins include meprin (a cell surface glycoprotein); A5 antigen (a developmentally-regulated cell surface protein); and receptor-like tyrosine protein phosphatase. The MAM domain is thought to have an adhesive function. It contains 4 conserved cysteine residues, which probably form disulphide bridges.

Human proteins containing this domain

ALK

Anaplastic lymphoma kinase

Anaplastic lymphoma kinase also known as ALK tyrosine kinase receptor or CD246 is an enzyme that in humans is encoded by the ALK gene.-Function:...

; EGFL6; MAMDC2; MAMDC4; MDGA1; MDGA2

MDGA2

MDGA2 is a human gene.It has previously been called MAMDC1.MDGA2 is located on chromosome 14.The gene has a homologue in rat and mouse, Mdga2,...

; MEP1A

MEP1A

Meprin A subunit alpha also known as endopeptidase-2 or PABA peptide hydrolase is the alpha subunit of the meprin A enzyme that in humans is encoded by the MEP1A gene...

; MEP1B

MEP1B

Meprin A subunit beta is a protein that in humans is encoded by the MEP1B gene.-Further reading:...

;
NPNT; NRP1

Neuropilin 1

Neuropilin-1 is a protein that in humans is encoded by the NRP1 gene.. This is one of two human neuropilins.-Interactions:Neuropilin 1 has been shown to interact with Vascular endothelial growth factor A.-Further reading:...

; NRP2

NRP2

Neuropilin-2 is a protein that in humans is encoded by the NRP2 gene.-Further reading:...

; PRSS7; PTPRK

PTPRK

Receptor-type tyrosine-protein phosphatase kappa is an enzyme that in humans is encoded by the PTPRK gene.-Interactions:PTPRK has been shown to interact with Beta-catenin and Plakoglobin.-Further reading:...

; PTPRM

PTPRM

Receptor-type tyrosine-protein phosphatase mu is an enzyme that in humans is encoded by the PTPRM gene.- Function :The protein encoded by this gene is a member of the protein tyrosine phosphatase family. Protein tyrosine phosphatases are protein enzymes that remove phosphate moieties from tyrosine...

; PTPRO

PTPRO

Receptor-type tyrosine-protein phosphatase O is an enzyme that in humans is encoded by the PTPRO gene.-Further reading:...

; PTPRT

PTPRT

Receptor-type tyrosine-protein phosphatase T is an enzyme that in humans is encoded by the PTPRT gene.PTPRT is also known as human accelerated region 9. It may, therefore, have played a key role in differentiating humans from apes.-Further reading:...

;
PTPRU

PTPRU

Receptor-type tyrosine-protein phosphatase U is an enzyme that in humans is encoded by the PTPRU gene.-Further reading:...

; ZAN