Metanx is a prescription medication made by Pamlab that contains L-methylfolate (vitamin B₉), methylcobalamin (vitamin B₁₂) and pyridoxal 5'-phosphate (vitamin B₆). It is a vitamin B supplement.

It is indicated for the treatment of endothelial dysfunction

Endothelial dysfunction

Endothelial dysfunction is a systemic pathological state of the endothelium and can be broadly defined as an imbalance between vasodilating and vasoconstricting substances produced by the endothelium...

 and hyperhomocysteinemia

Hyperhomocysteinemia

Hyperhomocysteinemia or hyperhomocysteinaemia is a medical condition characterized by an abnormally large level of homocysteine in the blood....

. In particular it has been shown to be an effective treatment for diabetic peripheral neuropathy

Diabetic neuropathy

Diabetic neuropathies are neuropathic disorders that are associated with diabetes mellitus. These conditions are thought to result from diabetic microvascular injury involving small blood vessels that supply nerves in addition to macrovascular conditions that can culminate in diabetic neuropathy...

 and lower extremity ulcerations such as diabetic foot ulcers

Diabetic foot

Diabetic foot ulcer is one of the major complications of diabetes mellitus, and probably the major component of the diabetic foot. It occurs in 15% of all patients with diabetes and precedes 84% of all lower leg amputations...

.

Metanx contains the following active ingredients (per tablet):

• L-methylfolate (Metafolin): 2.8 mg
• Pyridoxal 5'-phosphate: 25 mg
• Methylcobalamin: 2 mg