Michael D. Lockshin
Encyclopedia
Michael D. Lockshin, M.D.
, is an American professor and medical researcher. He is a researcher of autoimmune diseases, with focus on antiphospholipid syndrome
and lupus
. He is currently Professor of Medicine and Obstetrics-Gynecology at the Weill-Cornell University Medical College in New York City.
Locksin's twin brother, Richard A. Lockshin
, is an American cellular biologist known for his work on apoptosis
.
with an BA
in history and literature. He received his MD from Harvard Medical School
. Lockshin interned and did his residency at Bellevue Hospital
and Memorial Hospital for Cancer and Allied Diseases and his fellowship in Rheumatic Diseases at Columbia Presbyterian Medical Center in New York City.
(SLE), antiphospholipid syndrome
(APS), pregnancy in rheumatic disease patients, gender and rheumatic disease, and neurological SLE. His research has been supported by grants from NIAMS, the Arthritis Foundation
, the SLE Foundation, and private donors throughout his academic career.
He is director of the Barbara Volcker Center for Women and Rheumatic Disease and co-director of the Mary Kirkland Center for Lupus Research at the Hospital for Special Surgery
.
Locksin served as editor-in-chief of Arthritis & Rheumatism
for five years. He has also served on the editorial board of the Journal of Rheumatology, and as a reviewer for the New England Journal of Medicine, the Journal of Clinical Investigation, and the Journal of Immunology.
Lockshin has held senior management positions at the National Institutes of Health
in Bethesda, Maryland
. He served first as director of the Extramural Program of the National Institute of Arthritis and Musculoskeletal and Skin Diseases
(NIAMS) and then as acting director of the Institute. This Institute is responsible for U.S. government research funding in the fields of rheumatology and dermatology. He also served as Senior Advisor to the Director at the NIH's Warren G. Magnuson Clinical Center.
in 2003 and a Research Hero of the Arthritis Foundation in 2001. He is an honorary faculty member of Alpha Omega Alpha
.
Doctor of Medicine
Doctor of Medicine is a doctoral degree for physicians. The degree is granted by medical schools...
, is an American professor and medical researcher. He is a researcher of autoimmune diseases, with focus on antiphospholipid syndrome
Antiphospholipid syndrome
Antiphospholipid syndrome or antiphospholipid antibody syndrome , often also Hughes syndrome, is an autoimmune, hypercoagulable state caused by antibodies against cell-membrane phospholipids that provokes blood clots in both arteries and veins as well as pregnancy-related complications such as...
and lupus
Systemic lupus erythematosus
Systemic lupus erythematosus , often abbreviated to SLE or lupus, is a systemic autoimmune disease that can affect any part of the body. As occurs in other autoimmune diseases, the immune system attacks the body's cells and tissue, resulting in inflammation and tissue damage...
. He is currently Professor of Medicine and Obstetrics-Gynecology at the Weill-Cornell University Medical College in New York City.
Locksin's twin brother, Richard A. Lockshin
Richard A. Lockshin
Richard A. Lockshin is an American cellular biologist known for his work on apoptosis.He was educated at Harvard University where, in 1959, he obtained his bachelor's degree. This was followed by doctoral studies at Harvard University under the guidance of Carroll Williams...
, is an American cellular biologist known for his work on apoptosis
Apoptosis
Apoptosis is the process of programmed cell death that may occur in multicellular organisms. Biochemical events lead to characteristic cell changes and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, and chromosomal DNA fragmentation...
.
Education and training
Lockshin graduated cum laude from Harvard CollegeHarvard College
Harvard College, in Cambridge, Massachusetts, is one of two schools within Harvard University granting undergraduate degrees...
with an BA
Bachelor of Arts
A Bachelor of Arts , from the Latin artium baccalaureus, is a bachelor's degree awarded for an undergraduate course or program in either the liberal arts, the sciences, or both...
in history and literature. He received his MD from Harvard Medical School
Harvard Medical School
Harvard Medical School is the graduate medical school of Harvard University. It is located in the Longwood Medical Area of the Mission Hill neighborhood of Boston, Massachusetts....
. Lockshin interned and did his residency at Bellevue Hospital
Bellevue Hospital Center
Bellevue Hospital Center, most often referred to as "Bellevue", was founded on March 31, 1736 and is the oldest public hospital in the United States. Located on First Avenue in the Kips Bay neighborhood of Manhattan, New York City, Bellevue is famous from many literary, film and television...
and Memorial Hospital for Cancer and Allied Diseases and his fellowship in Rheumatic Diseases at Columbia Presbyterian Medical Center in New York City.
Work
His long-term research interest is in the clinical aspects of systemic lupus erythematosusSystemic lupus erythematosus
Systemic lupus erythematosus , often abbreviated to SLE or lupus, is a systemic autoimmune disease that can affect any part of the body. As occurs in other autoimmune diseases, the immune system attacks the body's cells and tissue, resulting in inflammation and tissue damage...
(SLE), antiphospholipid syndrome
Antiphospholipid syndrome
Antiphospholipid syndrome or antiphospholipid antibody syndrome , often also Hughes syndrome, is an autoimmune, hypercoagulable state caused by antibodies against cell-membrane phospholipids that provokes blood clots in both arteries and veins as well as pregnancy-related complications such as...
(APS), pregnancy in rheumatic disease patients, gender and rheumatic disease, and neurological SLE. His research has been supported by grants from NIAMS, the Arthritis Foundation
Arthritis Foundation
The Arthritis Foundation is the largest national nonprofit organization solely dedicated to the prevention, control and cure of arthritis, the leading cause of disability in the United States....
, the SLE Foundation, and private donors throughout his academic career.
He is director of the Barbara Volcker Center for Women and Rheumatic Disease and co-director of the Mary Kirkland Center for Lupus Research at the Hospital for Special Surgery
Hospital for Special Surgery
Hospital for Special Surgery is a hospital in New York City that specializes in orthopedic surgery and the treatment of rheumatologic conditions....
.
Locksin served as editor-in-chief of Arthritis & Rheumatism
Arthritis & Rheumatism
Arthritis & Rheumatism is a peer-reviewed medical journal covering the natural history, pathophysiology, treatment, and outcome of the rheumatic diseases. It is an official journal of the American College of Rheumatology...
for five years. He has also served on the editorial board of the Journal of Rheumatology, and as a reviewer for the New England Journal of Medicine, the Journal of Clinical Investigation, and the Journal of Immunology.
Lockshin has held senior management positions at the National Institutes of Health
National Institutes of Health
The National Institutes of Health are an agency of the United States Department of Health and Human Services and are the primary agency of the United States government responsible for biomedical and health-related research. Its science and engineering counterpart is the National Science Foundation...
in Bethesda, Maryland
Bethesda, Maryland
Bethesda is a census designated place in southern Montgomery County, Maryland, United States, just northwest of Washington, D.C. It takes its name from a local church, the Bethesda Meeting House , which in turn took its name from Jerusalem's Pool of Bethesda...
. He served first as director of the Extramural Program of the National Institute of Arthritis and Musculoskeletal and Skin Diseases
National Institute of Arthritis and Musculoskeletal and Skin Diseases
The National Institute of Arthritis and Musculoskeletal and Skin Diseases, or NIAMS, is an institute of the National Institutes of Health, an agency of the United States Department of Health and Human Services...
(NIAMS) and then as acting director of the Institute. This Institute is responsible for U.S. government research funding in the fields of rheumatology and dermatology. He also served as Senior Advisor to the Director at the NIH's Warren G. Magnuson Clinical Center.
Honors
Lockshin received a Lifetime Achievement Award from the New York Arthritis Foundation in 2008. He was named a master of the American College of RheumatologyAmerican College of Rheumatology
The American College of Rheumatology is an organization of and for physicians, health professionals, and scientists that advances rheumatology through programs of education, research, advocacy and practice support that foster excellence in the care of people with arthritis and rheumatic and...
in 2003 and a Research Hero of the Arthritis Foundation in 2001. He is an honorary faculty member of Alpha Omega Alpha
Alpha Omega Alpha
The Alpha Omega Alpha Honor Medical Society, commonly called Alpha Omega Alpha and abbreviated ΑΩΑ or AOA, is a national honor society for medical students, residents, scientists and physicians in the United States and Canada.-History:...
.
Committee membership
He has served on numerous study sections and ad-hoc committees for the National Institutes of Health, the Veterans' Administration, the Canadian Arthritis and Rheumatism Society, the Canadian Medical Research Council, the SLE Foundation, among others.- Institute of Medicine Health Science Policy Committee, 2002-5
- National Academy of Sciences, Institute of Medicine, AXXS Workshop, 2002
- Institute of Medicine Committee on CDC’s Safety and Efficacy Research on Anthrax Vaccine, 2001-2
- Advisory Committee on Research on Women’s Health, National Institutes of Health, 2001-5
- Autoimmunity Centers of Excellence, Data and Safety Monitoring Committee, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 2000-4
- Institute of Medicine Committee on Understanding the Biology of Sex and Gender Differences, 1999–2001
- Alliance for Lupus Research, Scientific Executive Board, 2000-
- American Rheumatism Association: many committees and offices, including Education Committee (Chairman), Committee on Rheumatologic Practice (Chairman), Second Vice President, and Abstract Review Committees (Chairman)
- Arthritis Foundation: many committees and offices, including Board of Governors, Professional Education Committee (Chairman), Unproven Remedies Committee (Chairman)
- American Board of Internal Medicine: Sub Specialty Committee on Rheumatology (Chairman )
- American College of Physicians: Medical Knowledge Self-Assessment Program IX (Chairman)
- American Board of Medical Examiners: Member for Rheumatology
- SLE Foundation of America, Inc.: Medical Advisory Committee (Chairman)
Scientific publications
RELEVANT PEER-REVIEWED PUBLICATIONS (selected 2005–present, of 200+ total, includes reviews)- Buyon JP, Petri MA; Kim MY, Kalunian K, Grossman J, Hahn BH, Merrill JT, Sammaritano L, Lockshin M, Alarcon G, Manzi S, Belmont HM, Askanase AD, Sigler L, Dooley MA, Von Feldt J, McCune WJ, Alan Friedman F, Wachs J, Cronin M, Hearth-Holmes M, Tan M, MD Licciardi F, for the SELENA Investigators. Estrogen/cyclic progesterone replacement is associated with an increased rate of mild/moderate but not severe flares in SLE. Ann Intern Med 2005; 142:953-962.
- Roman MJ, Devereux RB, Schwartz JE, Lockshin MD, Paget SA, Davis A, Crow MK, Sammaritano L, Levine DM, Shankar BA, Elfi Moeller E, Salmon JE. Arterial stiffness in chronic inflammatory diseases. Hypertension. 2005;46:1-6.
- Tenedios F, Erkan D, Lockshin MD. Cardiac involvement in the antiphospholipid syndrome. Lupus 2005; 14: 691-6.
- Petri M, Kim MY, Kalunian KC, Grossman J, Hahn BH, Sammaritano LR, Lockshin M, Merrill JT, Belmont HM, Askanase AD, McCune WJ, Hearth-Holmes M, Dooley MA, Von Feldt J, Friedman A, Tan M, Davis J, Cronin M, Diamond B, Mackay M, Sigler L, Fillius M, Rupel A, Licciardi F, Buyon JP; OC- SELENA Trial. Combined oral contraceptives in women with systemic lupus erythematosus. N Engl J Med. 2005 Dec 15;353(24):2550-8.
- Harrison MJ, Ravdin LD, Lockshin MD. Relationship between serum NR2a antibodies and cognitive dysfunction in systemic lupus erythematosus. Arthritis Rheum. 2006 Jul 25;54(8):2515-2522 [Epub ahead of print]
- Ostensen M, Khamashta M, Lockshin M, Parke A, Brucato A, Carp H, Doria A, Rai R, Meroni P, Cetin I, Derksen R, Branch W, Motta M, Gordon C, Ruiz-Irastorza G, Spinillo A, Friedman D, Cimaz R, Czeizel A, Piette JC, Cervera R, Levy RA, Clementi M, De Carolis S, Petri M, Shoenfeld Y, Faden D, Valesini G, Tincani A. Anti-inflammatory and immunosuppressive drugs and reproduction. Arthritis Res Ther. 2006;8(3):209. Epub 2006 May 11.
- Roman MJ, Moeller E, Davis A, Paget SA, Crow MK, Lockshin MD, Sammaritano L, Devereux RB, Schwartz JE, Levine DM, Salmon JE. Preclinical carotid atherosclerosis in patients with rheumatoid arthritis. Ann Intern Med. 2006 Feb 21;144(4):249-56. Summary for patients in: Ann Intern Med. 2006 Feb 21;144(4):I38.
- Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, Derksen RH, DE Groot PG, Koike T, Meroni PL, Reber G, Shoenfeld Y, Tincani A, Vlachoyiannopoulos PG, Krilis SA. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost. 2006 Feb;4(2):295-306.
- Lockshin MD. Sex differences in autoimmune disease. Lupus 2006;15:1-4.
- Farzaneh-Far A, Roman MJ, Lockshin MD, Devereux RB, Paget SA, Crow MK, Davis A, Sammaritano L, Levine DM, Salmon JE. Relationship of antiphospholipid antibodies to cardiovascular manifestations of systemic lupus erythematosus. Arthritis Rheum. 2006 Dec;54(12):3918-25
- Lockshin MD; Mary Kirkland Center for Lupus Research Consortium. Biology of the sex and age distribution of systemic lupus erythematosus. Arthritis Rheum. 2007 May 15;57(4):608-11.
- Erkan D, Harrison MJ, Levy R, Peterson M, Petri M, Sammaritano L, Unalp-Arida A, Vilela V, Yazici Y, Lockshin MD. Aspirin for primary thrombosis prevention in the antiphospholipid syndrome: a randomized, double-blind, placebo-controlled trial in asymptomatic antiphospholipid antibody-positive individuals. Arthritis Rheum. 2007 Jul;56(7):2382-91.
- Pieretti J, Roman MJ, Devereux RB, Lockshin MD, Crow MK, Paget SA, Schwartz JE, Sammaritano L, Levine DM, Salmon JE. Systemic lupus erythematosus predicts increased left ventricular mass. Circulation. 2007 Jul 24;116(4):419-26.
- Kaul MS, Erkan D, Sammaritano L, Lockshin MD, Assessment of the 2006 revised antiphospholipid syndrome classification criteria, Ann Rheum Dis 2007;66:927–930
- Roman MJ, Crow MK, Lockshin MD, Devereux RB, Paget SA, Sammaritano L, Levine DM, Davis A, Salmon JE. Rate and determinants of progression of atherosclerosis in systemic lupus erythematosus. Arthritis Rheum. 2007 Oct;56(10):3412-9.
- Salmon JE, Girardi G, Lockshin MD. The antiphospholipid syndrome as a disorder initiated by inflammation: implications for the therapy of pregnant patients. Nat Clin Pract Rheumatol. 2007 Mar;3(3):140-7
- Doria A, Tincani A, Lockshin M. Challenges of lupus pregnancies. Rheumatology (Oxford). 2008 Jun;47 Suppl 3:iii9-12. PMID: 18504287 [PubMed - in process]
- Østensen M, Lockshin M, Doria A, Valesini G, Meroni P, Gordon C, Brucato A, Tincani A. Update in safety during pregnancy of biological agents and some immunosuppressive anti-rheumatic drugs. Rheumatology (Oxford). 2008 Jun;47 Suppl 3:iii28-31. PMID: 18504282 [PubMed - in process]
- Cutolo M, Matucci-Cerinic M, Lockshin M, Ostensen M. Introduction: new trends in pregnancy and rheumatic diseases. Rheumatology (Oxford). 2008 Jun;47 Suppl 3:iii1.
Books
- Dancing at the River's Edge: A Patient and Her Doctor Negotiate Life with Chronic Illness by Alida Brill and Michael D. Lockshin, M.D. (Hardcover, Schaffner Press, January 2009)
- The Hospital for Special Surgery Rheumatoid Arthritis Handbook by Stephen A. Paget, M.D., Michael D. Lockshin M.D., and Suzanne Loeb (Paperback, Wiley October 2001)
- Guarded Prognosis: A Doctor and His Patients Talk About Chronic Disease and How to Cope With It by Michael D. Lockshin, M.D. (Hardcover, Farrar Straus & Giroux, June 1998)