N-terminal prohormone of brain natriuretic peptide
Encyclopedia
The N-terminal prohormone of brain natriuretic peptide (NT-proBNP) is a 76 amino acid N-terminal fragment of brain natriuretic peptide
.
Both BNP and NT-proBNP levels in the blood are used for screening, diagnosis of acute congestive heart failure
(CHF) and may be useful to establish prognosis in heart failure, as both markers are typically higher in patients with worse outcome. The plasma concentrations of both BNP and NT-proBNP are also typically increased in patients with asymptomatic or symptomatic left ventricular dysfunction.
!colspan=4| Upper limit (95th percentile) of blood ranges
for NT-proBNP in healthy people
|-
! Sex !! Age !! Limit
in pg/mL
|-
|rowspan=5| Male > < 45 yrs
| 45-54 yrs
| 55-64 yrs
| 65-74 yrs
| > 75 yrs
|rowspan=5| Females < 45 yrs
| 45-54 yrs
| 55-64 yrs
| 65-74 yrs
| > 75 yrs
There is no level of BNP that perfectly separates patients with and without heart failure.
In screening for congenital heart disease in pediatric patients, an NT-proBNP cut-off value of 91 pg/mL could differentiate an acyanotic heart disease (ACNHD) patient from a healthy patient with a sensitivity
of 84% and specificity
of 42%. On the other hand, an NT-proBNP cut-off value of 318 pg/mL is more appropriate in differing patients with congenital nonspherocytic hemolytic disease (CNHD) from healthy patients, with 94% sensitivity and 97% specificity. An NT-proBNP value of 408 pg/mL has been estimated to be 83% sensitive and 57% specific in differentiating patients with ACNHD from patients with CNHD.
Brain natriuretic peptide
Brain natriuretic peptide , now known as B-type natriuretic peptide or GC-B, is a 32 amino acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of heart muscle cells...
.
Both BNP and NT-proBNP levels in the blood are used for screening, diagnosis of acute congestive heart failure
Congestive heart failure
Heart failure often called congestive heart failure is generally defined as the inability of the heart to supply sufficient blood flow to meet the needs of the body. Heart failure can cause a number of symptoms including shortness of breath, leg swelling, and exercise intolerance. The condition...
(CHF) and may be useful to establish prognosis in heart failure, as both markers are typically higher in patients with worse outcome. The plasma concentrations of both BNP and NT-proBNP are also typically increased in patients with asymptomatic or symptomatic left ventricular dysfunction.
Blood levels
for NT-proBNP in healthy people
|-
! Sex !! Age !! Limit
in pg/mL
Mass concentration
In astronomy or astrophysics mass concentration or mascon is a region of a planet or moon's crust that contains a large positive gravitational anomaly. In general, the word "mascon" can be used as a noun to describe an excess distribution of mass on or beneath the surface of a planet , such as Hawaii...
|-
|rowspan=5| Male >
| 45-54 yrs
| 55-64 yrs
| 65-74 yrs
| > 75 yrs
|rowspan=5| Females
| 45-54 yrs
| 55-64 yrs
| 65-74 yrs
| > 75 yrs
| Interpretation | Age | Range |
|---|---|---|
| Congestive heart failure Congestive heart failure Heart failure often called congestive heart failure is generally defined as the inability of the heart to supply sufficient blood flow to meet the needs of the body. Heart failure can cause a number of symptoms including shortness of breath, leg swelling, and exercise intolerance. The condition... likely |
<75years | > 125 pg/mL |
| >75 years | >450pg/mL |
There is no level of BNP that perfectly separates patients with and without heart failure.
In screening for congenital heart disease in pediatric patients, an NT-proBNP cut-off value of 91 pg/mL could differentiate an acyanotic heart disease (ACNHD) patient from a healthy patient with a sensitivity
Sensitivity and specificity
Sensitivity and specificity are statistical measures of the performance of a binary classification test, also known in statistics as classification function. Sensitivity measures the proportion of actual positives which are correctly identified as such Sensitivity and specificity are statistical...
of 84% and specificity
Sensitivity and specificity
Sensitivity and specificity are statistical measures of the performance of a binary classification test, also known in statistics as classification function. Sensitivity measures the proportion of actual positives which are correctly identified as such Sensitivity and specificity are statistical...
of 42%. On the other hand, an NT-proBNP cut-off value of 318 pg/mL is more appropriate in differing patients with congenital nonspherocytic hemolytic disease (CNHD) from healthy patients, with 94% sensitivity and 97% specificity. An NT-proBNP value of 408 pg/mL has been estimated to be 83% sensitive and 57% specific in differentiating patients with ACNHD from patients with CNHD.