SKF-83959
Encyclopedia
SKF-83,959 is a synthetic
benzazepine
derivative used in scientific research which acts as a selective
D1 receptor antagonist
and D5 receptor full agonist, as evidenced by the fact that it has high affinity for both receptors and stimulates the D5-linked PLC
/PI
second messenger pathway
without affecting the cAMP
/AC pathway which is linked to D1.
Chemical synthesis
In chemistry, chemical synthesis is purposeful execution of chemical reactions to get a product, or several products. This happens by physical and chemical manipulations usually involving one or more reactions...
benzazepine
Benzazepine
Benzazepines are chemical compounds containing both a benzene and an azepine group.Examples include fenoldopam....
derivative used in scientific research which acts as a selective
Binding selectivity
Binding selectivity refers to the differing affinities with which different ligands bind to a substrate forming a complex. A selectivity coefficient is the equilibrium constant for the reaction of displacement by one ligand of another ligand in a complex with the substrate...
D1 receptor antagonist
Receptor antagonist
A receptor antagonist is a type of receptor ligand or drug that does not provoke a biological response itself upon binding to a receptor, but blocks or dampens agonist-mediated responses...
and D5 receptor full agonist, as evidenced by the fact that it has high affinity for both receptors and stimulates the D5-linked PLC
Phospholipase C
Phosphoinositide phospholipase C is a family of eukaryotic intracellular enzymes that play an important role in signal transduction processes. In general, this enzyme is denoted as Phospholipase C, although three other families of phospholipase C enzymes have been identified in bacteria and in...
/PI
Phosphatidylinositol
Phosphatidylinositol is a negatively charged phospholipid and a minor component in the cytosolic side of eukaryotic cell membranes....
second messenger pathway
Second messenger system
Second messengers are molecules that relay signals from receptors on the cell surface to target molecules inside the cell, in the cytoplasm or nucleus. They relay the signals of hormones like epinephrine , growth factors, and others, and cause some kind of change in the activity of the cell...
without affecting the cAMP
Cyclic adenosine monophosphate
Cyclic adenosine monophosphate is a second messenger important in many biological processes...
/AC pathway which is linked to D1.