Tabtoxinine β-lactam
Encyclopedia
Tabtoxinine β-lactam is a monobactam antibiotic
derived from tabtoxin
. Unlike other β-lactam antibiotic
s, which inhibit penicillin-binding proteins, tabtoxinine β-lactam inhibits glutamine synthetase
.
Antibiotic
An antibacterial is a compound or substance that kills or slows down the growth of bacteria.The term is often used synonymously with the term antibiotic; today, however, with increased knowledge of the causative agents of various infectious diseases, antibiotic has come to denote a broader range of...
derived from tabtoxin
Tabtoxin
Tabtoxin, also known as wildfire toxin, is a simple monobactam biotoxin produced by Pseudomonas syringae. It is the precursor to the antibiotic tabtoxinine β-lactam....
. Unlike other β-lactam antibiotic
Beta-lactam antibiotic
β-Lactam antibiotics are a broad class of antibiotics, consisting of all antibiotic agents that contains a β-lactam nucleus in its molecular structure. This includes penicillin derivatives , cephalosporins , monobactams, and carbapenems...
s, which inhibit penicillin-binding proteins, tabtoxinine β-lactam inhibits glutamine synthetase
Glutamine synthetase
Glutamine synthetase is an enzyme that plays an essential role in the metabolism of nitrogen by catalyzing the condensation of glutamate and ammonia to form glutamine:Glutamate + ATP + NH3 → Glutamine + ADP + phosphate...
.