Structural failures, such as bank failures and stock market crashes, are among the major causes of the Great Depression.

Some economists point to Britain's adherence to the Gold Standard after WW I as one of the causes of the Great Depression.

Until 1935 there were no restrictions on borrowing far more than tangible assets value (debt ratio). The huge loans were based on projected future earnings. A similar scenario again returned into vogue in the late 1990's with the Carter administrations long dormant 'Community Re-investment Act' being given 'power of enforcement' by the Clinton administrations Congress.

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Simply immorality !

The stock market crash of 1929. During the 1920s the U.S. stock market underwent a historic expansion. ...
Banking panics and monetary contraction. ...
The gold standard. ...
Decreased international lending and tariffs.

Total debt to GDP levels in the U.S. reached a high of just under 300% by the time of the Depression. This level of debt was not exceeded again until near the end of the 20th century

The volume of new capital issues increased at a 7.7% compounded annual rate from 1922 to 1929 at a time when the Standard Statistics Co.'s index of 60 high grade bonds yielded from 4.98% in 1923 to 4.47% in 1927.

The U.S. stock market went too high, too fast. It was inevitable that a collapse would follow.

Money supply decreased significantly between Black Tuesday, October 24, 1929, and the Bank Holiday in March 1933 when there were massive bank runs across the United States.

There are the monetarists, who believe that the Great Depression started as an ordinary recession, but that significant policy mistakes by monetary authorities (especially the Federal Reserve) caused a shrinking of the money supply which greatly exacerbated the economic situation, causing a recession to descend into the Great Depression

Good old fashioned American greed.

Still with us today. They bankers almost cause another Great Depression in 2007.

The greedy never learn from their mistakes.

Some new classical macroeconomists have argued that various labor market policies imposed at the start caused the length and severity of the Great Depression.

With people's investments worthless, their savings diminished or depleted, and credit tight to nonexistent, spending by consumers and companies alike ground to a standstill. As a result, workers were laid off en masse.

It was just an inevitable consequence of the business cycle. There are ups and downs and occasionally those ups or downs are much more extreme than normal.

Greedy stock traders.

The Roaring Twenties had to come to an end at some point. It just happened more abruptly than anyone thought it would.

Herbert Hoover. Blame him.

Blame congress. Presidents have far less influence over the economy than presidents. Even more so back then.