Bruce H. Lipshutz
Encyclopedia
Bruce H. Lipshutz is an American chemist. He is a professor at the University of California, Santa Barbara
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and obtained a PhD degree in 1977. He spent two years at Harvard as a post-doctoral researcher in the group of Nobel Laureate E. J. Corey. Soon after, he accepted a position of Assistant Professor at UCSB rising to the ranks of Professor in 1987. He has received the Alfred P. Sloan Foundation
Fellowship and the Camille & Henry Dreyfus Teacher-Scholar Award. In 2011 he was awarded Presidential Green Chemistry Award. Bruce is Co-founder of Zymes LLC.
University of California, Santa Barbara
The University of California, Santa Barbara, commonly known as UCSB or UC Santa Barbara, is a public research university and one of the 10 general campuses of the University of California system. The main campus is located on a site in Goleta, California, from Santa Barbara and northwest of Los...
.
Biography
Bruce Lipshutz received his undergraduate degree in chemistry from SUNY Binghamton in 1973. He did his graduate work under the supervision of Professor Harry H. Wasserman at YaleYALE
RapidMiner, formerly YALE , is an environment for machine learning, data mining, text mining, predictive analytics, and business analytics. It is used for research, education, training, rapid prototyping, application development, and industrial applications...
and obtained a PhD degree in 1977. He spent two years at Harvard as a post-doctoral researcher in the group of Nobel Laureate E. J. Corey. Soon after, he accepted a position of Assistant Professor at UCSB rising to the ranks of Professor in 1987. He has received the Alfred P. Sloan Foundation
Alfred P. Sloan Foundation
The Alfred P. Sloan Foundation is a philanthropic non-profit organization in the United States. It was established in 1934 by Alfred P. Sloan, Jr., then-President and Chief Executive Officer of General Motors.-Overview:...
Fellowship and the Camille & Henry Dreyfus Teacher-Scholar Award. In 2011 he was awarded Presidential Green Chemistry Award. Bruce is Co-founder of Zymes LLC.
Reagents
- 2-(Trimethylsilyl)ethoxymethyl chloride: hydroxyl protecting group, selectively cleaved with fluoride ion under mild conditions.
- Di-(4-chlorobenzyl)azodicarboxylate (DCAD): recyclable and convenient alternative to diethylazodicarboxylate (DEAD) or diisopropyazodicarboxylate (DIAD) in Mitsunobu reactionMitsunobu reactionThe Mitsunobu reaction is an organic reaction that converts an alcohol into a variety of functional groups, such as an ester, using triphenylphosphine and an azodicarboxylate such as diethyl azodicarboxylate or diisopropyl azodicarboxylate . The alcohol undergoes an inversion of stereochemistry...
. - Ligated copper hydride.
- Heterogeneous catalysts: nickel-on-charcoal, copper-on-charcoal, nickel-in-graphite, copper+nickel-on-charcoal.
Methodologies
- Higher order organocuprates (Lipshutz cuprates).
- Chiral and achiral conjugate reductions.