Daniel L. Simmons
Encyclopedia
Daniel L. Simmons is a professor of chemistry and the director of the Cancer Research Center at Brigham Young University
(BYU). He was the discoverer of the COX-2 enzyme that is the target of celecoxib
(Celebrex) and other COX-2 inhibitor
s. He and BYU felt that Pfizer
had not properly credited or paid them for Simmons work in this development and brought a suit against Pfizer.
Simmons has bachelors and masters degrees from BYU. He earned his Ph.D. from the University of Wisconsin in 1986. From 1986-1989 he held a post-doctoral Fellowship at Harvard University
.
Simmons discovered the COX-2 and COX-3
enzymes.
Brigham Young University
Brigham Young University is a private university located in Provo, Utah. It is owned and operated by The Church of Jesus Christ of Latter-day Saints , and is the United States' largest religious university and third-largest private university.Approximately 98% of the university's 34,000 students...
(BYU). He was the discoverer of the COX-2 enzyme that is the target of celecoxib
Celecoxib
Celecoxib INN is a sulfa non-steroidal anti-inflammatory drug and selective COX-2 inhibitor used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms, and to reduce numbers of colon and rectum polyps in patients with familial...
(Celebrex) and other COX-2 inhibitor
COX-2 inhibitor
COX-2 selective inhibitor is a form of non-steroidal anti-inflammatory drug that directly targets COX-2, an enzyme responsible for inflammation and pain. Targeting selectivity for COX-2 reduces the risk of peptic ulceration, and is the main feature of celecoxib, rofecoxib and other members of this...
s. He and BYU felt that Pfizer
Pfizer
Pfizer, Inc. is an American multinational pharmaceutical corporation. The company is based in New York City, New York with its research headquarters in Groton, Connecticut, United States...
had not properly credited or paid them for Simmons work in this development and brought a suit against Pfizer.
Simmons has bachelors and masters degrees from BYU. He earned his Ph.D. from the University of Wisconsin in 1986. From 1986-1989 he held a post-doctoral Fellowship at Harvard University
Harvard University
Harvard University is a private Ivy League university located in Cambridge, Massachusetts, United States, established in 1636 by the Massachusetts legislature. Harvard is the oldest institution of higher learning in the United States and the first corporation chartered in the country...
.
Simmons discovered the COX-2 and COX-3
COX-3
COX-3 is an enzyme that is encoded by the PTGS1 gene, but is not functional in humans. COX-3 is the third and most recently discovered cyclooxygenase isozyme, the others being COX-1 and COX-2...
enzymes.