Dennis S. Charney
Encyclopedia
Dennis S. Charney is an American
biological psychiatrist
and researcher
, one of the world's leading experts in the neurobiology and treatment of mood
and anxiety disorders
. He is the author of Neurobiology of Mental Illness, The Physician's Guide to Depression and Bipolar Disorders and Molecular Biology for the Clinician, as well as the author of over 500 original papers and chapters.
He is a Professor of Psychiatry
, Professor of Neuroscience
and Professor of Pharmacology
and Systems Therapeutics at Mount Sinai School of Medicine
in New York City
, and currently Dean
of the school.
in 1977 and completed his residency in Psychiatry at Yale School of Medicine
. A fellowship in Biological Psychiatry was completed at the Connecticut Medical Health Center.
Charney became the Dean of Research at Mount Sinai School of Medicine in 2004, later becoming the Dean for Academic and Scientific Affairs, finally succeeding Kenneth L. Davis
as Dean of the school in 2007.
He has been named among the top 3 most highly cited authors of psychiatric research in the decade ending in 2000 by the Institute of Scientific Information, and listed in every edition of the “Best Doctors in America” since 1992.
He owns patents in dopamine
and noradrenergic reuptake inhibitors in treatment of schizophrenia
and in intranasal administration of ketamine
to treat depression.
He was elected to the Institute of Medicine
in 2000.
United States
The United States of America is a federal constitutional republic comprising fifty states and a federal district...
biological psychiatrist
Biological psychiatry
Biological psychiatry, or biopsychiatry is an approach to psychiatry that aims to understand mental disorder in terms of the biological function of the nervous system. It is interdisciplinary in its approach and draws on sciences such as neuroscience, psychopharmacology, biochemistry, genetics and...
and researcher
Biomedical research
Biomedical research , in general simply known as medical research, is the basic research, applied research, or translational research conducted to aid and support the body of knowledge in the field of medicine...
, one of the world's leading experts in the neurobiology and treatment of mood
Mood disorder
Mood disorder is the term designating a group of diagnoses in the Diagnostic and Statistical Manual of Mental Disorders classification system where a disturbance in the person's mood is hypothesized to be the main underlying feature...
and anxiety disorders
Anxiety disorder
Anxiety disorder is a blanket term covering several different forms of abnormal and pathological fear and anxiety. Conditions now considered anxiety disorders only came under the aegis of psychiatry at the end of the 19th century. Gelder, Mayou & Geddes explains that anxiety disorders are...
. He is the author of Neurobiology of Mental Illness, The Physician's Guide to Depression and Bipolar Disorders and Molecular Biology for the Clinician, as well as the author of over 500 original papers and chapters.
He is a Professor of Psychiatry
Psychiatry
Psychiatry is the medical specialty devoted to the study and treatment of mental disorders. These mental disorders include various affective, behavioural, cognitive and perceptual abnormalities...
, Professor of Neuroscience
Neuroscience
Neuroscience is the scientific study of the nervous system. Traditionally, neuroscience has been seen as a branch of biology. However, it is currently an interdisciplinary science that collaborates with other fields such as chemistry, computer science, engineering, linguistics, mathematics,...
and Professor of Pharmacology
Pharmacology
Pharmacology is the branch of medicine and biology concerned with the study of drug action. More specifically, it is the study of the interactions that occur between a living organism and chemicals that affect normal or abnormal biochemical function...
and Systems Therapeutics at Mount Sinai School of Medicine
Mount Sinai School of Medicine
Mount Sinai School of Medicine is an American medical school in the borough of Manhattan in New York City, currently ranked among the top 20 medical schools in the United States. It was chartered by Mount Sinai Hospital in 1963....
in New York City
New York City
New York is the most populous city in the United States and the center of the New York Metropolitan Area, one of the most populous metropolitan areas in the world. New York exerts a significant impact upon global commerce, finance, media, art, fashion, research, technology, education, and...
, and currently Dean
Dean (education)
In academic administration, a dean is a person with significant authority over a specific academic unit, or over a specific area of concern, or both...
of the school.
Biography
Charney graduated from medical school at Penn StatePenn State Hershey Medical Center
Penn State Milton S. Hershey Medical Center, located in Hershey, Pennsylvania, 10 miles east of Harrisburg, is Penn State’s medical school and academic medical center, and is the only medical school and university hospital in Pennsylvania located outside the urban areas of Philadelphia and...
in 1977 and completed his residency in Psychiatry at Yale School of Medicine
Yale School of Medicine
The Yale School of Medicine at Yale University is a private medical school located in New Haven, Connecticut, U.S. It was founded in 1810 as The Medical Institution of Yale College, and formally opened its doors in 1813....
. A fellowship in Biological Psychiatry was completed at the Connecticut Medical Health Center.
Charney became the Dean of Research at Mount Sinai School of Medicine in 2004, later becoming the Dean for Academic and Scientific Affairs, finally succeeding Kenneth L. Davis
Kenneth L. Davis
Kenneth L. Davis is an American author and medical researcher who developed the Alzheimer's Disease Assessment Scale, the most widely used tool to test the efficacy of treatments for Alzheimer's Disease designed specifically to evaluate the severity of cognitive and noncognitive behavioral...
as Dean of the school in 2007.
He has been named among the top 3 most highly cited authors of psychiatric research in the decade ending in 2000 by the Institute of Scientific Information, and listed in every edition of the “Best Doctors in America” since 1992.
He owns patents in dopamine
Dopamine
Dopamine is a catecholamine neurotransmitter present in a wide variety of animals, including both vertebrates and invertebrates. In the brain, this substituted phenethylamine functions as a neurotransmitter, activating the five known types of dopamine receptors—D1, D2, D3, D4, and D5—and their...
and noradrenergic reuptake inhibitors in treatment of schizophrenia
Schizophrenia
Schizophrenia is a mental disorder characterized by a disintegration of thought processes and of emotional responsiveness. It most commonly manifests itself as auditory hallucinations, paranoid or bizarre delusions, or disorganized speech and thinking, and it is accompanied by significant social...
and in intranasal administration of ketamine
Ketamine
Ketamine is a drug used in human and veterinary medicine. Its hydrochloride salt is sold as Ketanest, Ketaset, and Ketalar. Pharmacologically, ketamine is classified as an NMDA receptor antagonist...
to treat depression.
He was elected to the Institute of Medicine
Institute of Medicine
The Institute of Medicine is a not-for-profit, non-governmental American organization founded in 1970, under the congressional charter of the National Academy of Sciences...
in 2000.
Affiliations and positions
- Principal Investigator, VA National Center for Posttraumatic Stress Disorder and the NIMHNational Institutes of HealthThe National Institutes of Health are an agency of the United States Department of Health and Human Services and are the primary agency of the United States government responsible for biomedical and health-related research. Its science and engineering counterpart is the National Science Foundation...
Yale Mental Health Clinical Research Center. - Member, Food and Drug Administration Psychopharmacologic Drug Advisory Committee
- Editorial Committee, Biological Psychiatry, a Publication of the Society of Biological Psychiatry
- Former Chair, Board of Scientific Counselors for the National Institute of Mental HealthNational Institute of Mental HealthThe National Institute of Mental Health is one of 27 institutes and centers that make up the National Institutes of Health...
- Former Chair, Scientific Advisory Board of the Anxiety Disorders Association of AmericaAnxiety Disorders Association of AmericaThe Anxiety Disorders Association of America is the only U.S. nonprofit organization solely dedicated to increasing awareness and improving the diagnosis, treatment, and cure of anxiety disorders in children and adults. The Anxiety Disorders Association of America is the leader in education,...
(ADAA) - Former Chair, Depression and Bipolar Support AllianceDepression and Bipolar Support AllianceThe Depression and Bipolar Support Alliance is a non-profit organization providing support groups for people with depression or bipolar disorder as well as their friends and family. DBSA's scope, also includes outreach, education and advocacy regarding depression and bipolar disorder...
(DBSA) Scientific Advisory Board - Past President, American College of Neuropsychopharmacology
- Member, Scientific Advisory Board of the National Association for Research in Schizophrenia and Affective Disorders (NARSAD)
- Member, National Alliance for the Mentally Ill (NAMI)
- Former Scientific Director, NIMH Strategic Plan for Mood Disorder Research in 2002.
Awards and honors
- Efron Award from the American College of NeuropsychopharmacologyNeuropsychopharmacologyNeuropsychopharmacology is an interdisciplinary science related to psychopharmacology and fundamental neuroscience...
- Anna Monika Foundation Award for Research in Affective Disorders
- The Edward J. Sacher Award from Columbia UniversityColumbia UniversityColumbia University in the City of New York is a private, Ivy League university in Manhattan, New York City. Columbia is the oldest institution of higher learning in the state of New York, the fifth oldest in the United States, and one of the country's nine Colonial Colleges founded before the...
- The Edward A. Strecker Award from Pennsylvania HospitalPennsylvania HospitalPennsylvania Hospital is a hospital in Center City, Philadelphia, affiliated with the University of Pennsylvania Health System . Founded on May 11, 1751 by Benjamin Franklin and Thomas Bond, it was the first hospital in the United States...
and the University of PennsylvaniaUniversity of PennsylvaniaThe University of Pennsylvania is a private, Ivy League university located in Philadelphia, Pennsylvania, United States. Penn is the fourth-oldest institution of higher education in the United States,Penn is the fourth-oldest using the founding dates claimed by each institution... - The Gerald L. Klerman Lifetime Achievement Award from the Depression and Bipolar Support Alliance (DBSA)
- The Heinz Lehman Award from the New York State Department of Mental HealthGovernment of New YorkAs in all 50 states, the head of the executive branch of the government of New York is a Governor. The legislative branch is called the Legislature and consists of a Senate and an Assembly. Unlike most states, New York electoral law permits electoral fusion; thus New York ballots tend to show a...
- The American Psychiatric Association Award for Research
- The American College of Psychiatrists Award for Depression Research
- The Gold Medal Award from the Society of Biological Psychiatry
- Distinguished Alumni Award from the Pennsylvania State University School of Medicine
- The 2004 CINP-Lilly Neuroscience Clinical Research Award
Books
- Stress-induced and Fear Circuitry Disorders: Refining the Research Agenda for Dsm-v by Gavin Andrews, Dennis S. Charney, Paul J. Sirovatka, Darrel A. Regier, American Psychiatric Publishing, ISBN 089042344X
- Molecular Biology for the Clinician, by Dennis S. Charney, American Psychiatric Press, ISBN 9781585621132
- The Physician's Guide to Depression & Bipolar Disorders by Dennis S. Charney, Lydia Lewis, McGraw-Hill, ISBN 0071441751 (0-07-144175-1)
- Neurobiology of Mental Illness by Eric J. NestlerEric J. NestlerEric J. Nestler, M.D., Ph.D., is the Nash Family Professor of Neuroscience, Chairman of the Department of Neuroscience and Director of the Friedman Brain Institute at the Mount Sinai Medical Center in New York...
, Dennis S. Charney, Oxford Press, ISBN 0195189809 (0-19-518980-9) - Pediatric Psychoparmacology: Principles and Practice by James F. Leckman, Dennis S. Charney, Lawrence Scahill, Andres Martin, Oxford Univ Pr, ISBN 0195141733 (0-19-514173-3)
- Neurobiological and Clinical Consequences of Stress: From Normal Adaptation to Post-Traumatic Stress Disorder by Matthew J. Friedman, Dennis S. Charney, Ariel Y. Deutch, Lippincott Williams & Wilkins, ISBN 0781701775 (0-7817-0177-5)
- Neuropsychopharmacology: The Fifth Generation of Progress by American College of Neuropsychopharmacology and Joseph T. Coyle and Charles Nemeroff and Dennis Charney and Kenneth L. DavisKenneth L. DavisKenneth L. Davis is an American author and medical researcher who developed the Alzheimer's Disease Assessment Scale, the most widely used tool to test the efficacy of treatments for Alzheimer's Disease designed specifically to evaluate the severity of cognitive and noncognitive behavioral...
, Hardcover, Lippincott Williams & Wilkins, ISBN 0781728371 (0-7817-2837-1)
Publications
- Trauma and Resilience in the Third Year of Medical School: A Prospective Study of the Effects of Clinical Rotations on Student Well-being. Haglund M, aan het Rot M, Cooper N, Muller DDavid MüllerDavid Müller is a German footballer.In August 2009 his transfer to Sportfreunde Siegen was confirmed. In January 2010 Müller joined TSV Germania Windeck. In July 2011 he moved to FC Viktoria Köln 1904.-References:...
, Southwick SM, Charney DS. Academic Medicine, February 2009; 84(2):258-68. PMID 19174682 - Enduring mental health morbidity and social function impairment in world trade center rescue, recovery, and cleanup workers: the psychological dimension of an environmental health disaster. Stellman JM, Smith RP, Katz CL, Sharma V, Charney DS, Herbert R, Moline J, Luft BJ, Markowitz S, Udasin I, Harrison D, Baron S, Landrigan PJPhilip J. LandriganPhilip J. Landrigan, M.D., M.Sc., is an American epidemiologist and pediatrician and one of the world's leading advocates of children's health....
, Levin SM, Southwick S. Environ Health Perspect, 2008 PMID 18795171 - Novel drugs and therapeutic targets for severe mood disorders. Mathew SJ, Manji HK, Charney DS. NeuropsychopharmacologyNeuropsychopharmacology (journal)Neuropsychopharmacology is a scientific journal published by the Nature Publishing Group. Since 1994, Neuropsychopharmacology has been the official publication of the ....
. 2008 Aug;33(9):2300. Epub 2008 Jun 4. PMID 18536697 - Integration of in vivo and in vitro approaches to characterize the toxicity of Antalarmin, a corticotropin-releasing hormone receptor antagonist. Horn TL, Harder JB, Johnson WD, Curry PT, Parchment RE, Morrissey RL, Mellick PW, Calis KA, Gold PW, Rice KC, Contoreggi C, Charney DS, Cizza G, Glaze ER, Tomaszewski JE, McCormick DL. Toxicology. 2008 Jun 3;248(1):8-17. Epub 2008 Mar 13. PMID 18423834
- Recent advances in the neurobiology of anxiety disorders: implications for novel therapeutics. Mathew SJ, Price RB, Charney DS. Am J Med Genet C Semin Med Genet. 2008 May 15;148(2):89-98. PMID 18412102
- Response to Emotional Expressions in Generalized Social Phobia and Generalized Anxiety Disorder: Evidence for Separate Disorders. Blair K, Shaywitz J, Smith BW, Rhodes R, Geraci M, Jones M, McCaffrey D, Vythilingam M, Finger E, Mondillo K, Jacobs M, Charney DS, Blair RJ, Drevets WC, Pine DS. American Journal of Psychiatry. 2008 May 15. PMID 18483136
- Hippocampal N-acetylaspartate concentration and response to riluzole in generalized anxiety disorder. Mathew SJ, Price RB, Mao X, Smith EL, Coplan JD, Charney DS, Shungu DC. Biological Psychiatry. 2008 May 1;63(9):891-8. PMID 18028881
- Association between level of emotional intelligence and severity of anxiety in generalized social phobia. Jacobs M, Snow J, Geraci M, Vythilingam M, Blair RJ, Charney DS, Pine DS, Blair KS. Journal of Anxiety Disorder. 2008 Mar 13. PMID 18439799
- Mental health of workers and volunteers responding to events of 9/11: review of the literature. Bills CB, Levy NA, Sharma V, Charney DS, Herbert R, Moline J, Katz CL. PMID 18500712
- Plasma NPY concentrations during tryptophan and sham depletion in medication-free patients with remitted depression. Czermak C, Hauger R, Drevets WC, Luckenbaugh DA, Geraci M, Charney DS, Neumeister A. Journal of Affective Disorder. 2008 Feb 15. PMID 18281099
- Recognition of facial emotions among maltreated children with high rates of post-traumatic stress disorder. Masten CL, Guyer AE, Hodgdon HB, McClure EB, Charney DS, Ernst M, Kaufman J, Pine DS, Monk CS. Child Abuse Negl. 2008 Jan;32(1):139-53. Epub 2007 Dec 21. PMID 18155144
- Elevated serotonin transporter binding in major depressive disorder assessed using positron emission tomography and [11C]DASB; comparison with bipolar disorder. Cannon DM, Ichise M, Rollis D, Klaver JM, Gandhi SK, Charney DS, Manji HK, Drevets WC. Biological Psychiatry. 2007 Oct 15;62(8):870-7. Epub 2007 Aug 2. PMID 17678634
- Sustained low-grade pro-inflammatory state in unmedicated, remitted women with major depressive disorder as evidenced by elevated serum levels of the acute phase proteins C-reactive protein and serum amyloid A. Kling MA, Alesci S, Csako G, Costello R, Luckenbaugh DA, Bonne O, Duncko R, Drevets WC, Manji HK, Charney DS, Gold PW, Neumeister A. Biological Psychiatry. 2007 Aug 15;62(4):309-13. PMID 17178112
- Diagnosing bipolar disorder in trauma exposed primary care patients. Graves RE, Alim TN, Aigbogun N, Chrishon K, Mellman TA, Charney DS, Lawson WB. Bipolar Disorder. 2007 Jun;9(4):318-23. PMID 17547578
- Impact of publicity concerning pediatric suicidality data on physician practice patterns in the United States. Nemeroff CB, Kalali A, Keller MB, Charney DS, Lenderts SE, Cascade EF, Stephenson H, Schatzberg AF. Arch Gen Psychiatry. 2007 Apr;64(4):466-72. PMID 17404123
- Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder. McClure EB, Monk CS, Nelson EE, Parrish JM, Adler A, Blair RJ, Fromm S, Charney DS, Leibenluft E, Ernst M, Pine DS. Arch Gen Psychiatry. 2007 Jan;64(1):97-106. PMID 17199059
External links
- Mount Sinai Hospital homepage
- Mount Sinai School of Medicine homepage
- Biological Psychiatry: A Journal of Psychiatric Neuroscience and Therapeutics
- Video: Demons of Mind: Neuroscience and Other Weapons, Library of Congress
- Video: Coping with Anxiety and Depression in Uncertain Times, National Library of Medicine