Elizabeth H. Field
Encyclopedia
Elizabeth Hirak Field is an academic scholar and professor in the University of Iowa
’s Department of Internal Medicine.
Field received her BS
degree in Physics (Magna Cum Laude) from Millersville University of Pennsylvania
. She received her MD
degree from Penn State's Hershey Medical Center where she also performed her residency in Internal Medicine
. She conducted a five-year post doctorate fellowship in both Immunology
and Rheumatology
at Stanford University
School of Medicine, Stanford, CA. Field has served as a Professor in the Department of Internal Medicine, University of Iowa
College of Medicine, Iowa City, Iowa since 1986. She also directs the VA Medical Center. Iowa Regional Histocompatibility and Immunogenetics Laboratory http://www.healthcare.uiowa.edu/path_handbook/Appendix/TechServ/histocompt_req.html.
Field has conducted research http://www.int-med.uiowa.edu/Divisions/Immunology/Directory/ElizabethField.html in transplantation
immunology
, immunologic tolerance and CD4+CD25+ regulatory cells and has a patent pending for: CD4+CD25+ Inhibitory Hybridoma Clones. Field's research focuses on mechanisms of acquired immunologic tolerance by studying mouse models of neonatal tolerance and acquired tolerance in the adult. Acquired tolerance in the adult is accomplished using total lymphoid irradiation (TLI) and hematopoietic cell transfer to establish donor mixed-chimerism. In both neonatal and adult models of tolerance, IL-4 has been identified as a necessary cytokine for tolerance induction. CD4+-TNK cells, which produce high levels of IL-4, are enriched by TLI treatment and may play an important role in tolerance induction. Field's laboratory has identified CD4+CD25+ regulatory cells that inhibit CD8+ alloreactivity in mice with acquired tolerance to foreign MHC. CD4+CD25+ hybridomas have been generated from tolerant mice. These CD4+CD25+ hybridomas resemble in function the naturally occurring CD4+CD25+ regulatory cells. The laboratory is currently investigating the cellular and molecular mechanisms by which the CD4+CD25+ regulatory cells inhibit alloreactivity as well as T:B cell interactions in the induction and maintenance of tolerance. Field's research on tolerance is especially relevant to gene therapy and host immunoreactivity to viral vectors and/or neoantigens from the vectors system or from the delivered gene.
Field has earned numerous scholarships and academic honors including VA Career Development Award, Northern Illinois Chapter of the Lupus Foundation, Outstanding Investigator of the Central Society for Clinical Research, Alumni Fellow Award, Penn State University College of Medicine; 2006 Millersville University of Pennsylvania
commencement speaker; Invited Speaker at the Keystone Symposium, Invited Speaker at the 6th Basic Sciences Symposium of the Transplantation Society in Asilomar, CA., and Invited Speaker at the 32nd Annual Immunology Conference in Chicago. Other honors include: Northern California Chapter of the Arthritis Foundation Fellowship, Pfizer Medical Research Merit Award, ARA Senior Rheumatology Scholar Award, Giannini Foundation Medical Research Fellow and Teaching Recognition for Introduction to Clinical Medicine.
An active participant in many organizations, Field has been involved with the American Association for the Advancement of Science
, American Association of Immunologists, American College of Physicians, American College of Rheumatology, American Federation of Clinical Research, American Federal for Medical Research, American Society of Histocompatibility & Immunogenetics, American Society of Transplantation, American Society for Clinical Investigation, Central Society for Clinical Research, Clinical Immunology Society, Transplantation Society, and a Diplomate for both the National Board of Medical Examiners and the American Board of Internal Medicine.
In addition, she has written numerous articles for peer-reviewed publications and has a variety of ongoing research support work.
University of Iowa
The University of Iowa is a public state-supported research university located in Iowa City, Iowa, United States. It is the oldest public university in the state. The university is organized into eleven colleges granting undergraduate, graduate, and professional degrees...
’s Department of Internal Medicine.
Field received her BS
Bachelor of Science
A Bachelor of Science is an undergraduate academic degree awarded for completed courses that generally last three to five years .-Australia:In Australia, the BSc is a 3 year degree, offered from 1st year on...
degree in Physics (Magna Cum Laude) from Millersville University of Pennsylvania
Millersville University of Pennsylvania
Millersville University of Pennsylvania is a public university in Millersville, Pennsylvania, USA, 3 miles southwest of Lancaster. Millersville University is a member of the Pennsylvania State System of Higher Education.-History:...
. She received her MD
Doctor of Medicine
Doctor of Medicine is a doctoral degree for physicians. The degree is granted by medical schools...
degree from Penn State's Hershey Medical Center where she also performed her residency in Internal Medicine
Internal medicine
Internal medicine is the medical specialty dealing with the prevention, diagnosis, and treatment of adult diseases. Physicians specializing in internal medicine are called internists. They are especially skilled in the management of patients who have undifferentiated or multi-system disease processes...
. She conducted a five-year post doctorate fellowship in both Immunology
Immunology
Immunology is a broad branch of biomedical science that covers the study of all aspects of the immune system in all organisms. It deals with the physiological functioning of the immune system in states of both health and diseases; malfunctions of the immune system in immunological disorders ; the...
and Rheumatology
Rheumatology
Rheumatology is a sub-specialty in internal medicine and pediatrics, devoted to diagnosis and therapy of rheumatic diseases. Clinicians who specialize in rheumatology are called rheumatologists...
at Stanford University
Stanford University
The Leland Stanford Junior University, commonly referred to as Stanford University or Stanford, is a private research university on an campus located near Palo Alto, California. It is situated in the northwestern Santa Clara Valley on the San Francisco Peninsula, approximately northwest of San...
School of Medicine, Stanford, CA. Field has served as a Professor in the Department of Internal Medicine, University of Iowa
University of Iowa
The University of Iowa is a public state-supported research university located in Iowa City, Iowa, United States. It is the oldest public university in the state. The university is organized into eleven colleges granting undergraduate, graduate, and professional degrees...
College of Medicine, Iowa City, Iowa since 1986. She also directs the VA Medical Center. Iowa Regional Histocompatibility and Immunogenetics Laboratory http://www.healthcare.uiowa.edu/path_handbook/Appendix/TechServ/histocompt_req.html.
Field has conducted research http://www.int-med.uiowa.edu/Divisions/Immunology/Directory/ElizabethField.html in transplantation
Organ transplant
Organ transplantation is the moving of an organ from one body to another or from a donor site on the patient's own body, for the purpose of replacing the recipient's damaged or absent organ. The emerging field of regenerative medicine is allowing scientists and engineers to create organs to be...
immunology
Immunology
Immunology is a broad branch of biomedical science that covers the study of all aspects of the immune system in all organisms. It deals with the physiological functioning of the immune system in states of both health and diseases; malfunctions of the immune system in immunological disorders ; the...
, immunologic tolerance and CD4+CD25+ regulatory cells and has a patent pending for: CD4+CD25+ Inhibitory Hybridoma Clones. Field's research focuses on mechanisms of acquired immunologic tolerance by studying mouse models of neonatal tolerance and acquired tolerance in the adult. Acquired tolerance in the adult is accomplished using total lymphoid irradiation (TLI) and hematopoietic cell transfer to establish donor mixed-chimerism. In both neonatal and adult models of tolerance, IL-4 has been identified as a necessary cytokine for tolerance induction. CD4+-TNK cells, which produce high levels of IL-4, are enriched by TLI treatment and may play an important role in tolerance induction. Field's laboratory has identified CD4+CD25+ regulatory cells that inhibit CD8+ alloreactivity in mice with acquired tolerance to foreign MHC. CD4+CD25+ hybridomas have been generated from tolerant mice. These CD4+CD25+ hybridomas resemble in function the naturally occurring CD4+CD25+ regulatory cells. The laboratory is currently investigating the cellular and molecular mechanisms by which the CD4+CD25+ regulatory cells inhibit alloreactivity as well as T:B cell interactions in the induction and maintenance of tolerance. Field's research on tolerance is especially relevant to gene therapy and host immunoreactivity to viral vectors and/or neoantigens from the vectors system or from the delivered gene.
Field has earned numerous scholarships and academic honors including VA Career Development Award, Northern Illinois Chapter of the Lupus Foundation, Outstanding Investigator of the Central Society for Clinical Research, Alumni Fellow Award, Penn State University College of Medicine; 2006 Millersville University of Pennsylvania
Millersville University of Pennsylvania
Millersville University of Pennsylvania is a public university in Millersville, Pennsylvania, USA, 3 miles southwest of Lancaster. Millersville University is a member of the Pennsylvania State System of Higher Education.-History:...
commencement speaker; Invited Speaker at the Keystone Symposium, Invited Speaker at the 6th Basic Sciences Symposium of the Transplantation Society in Asilomar, CA., and Invited Speaker at the 32nd Annual Immunology Conference in Chicago. Other honors include: Northern California Chapter of the Arthritis Foundation Fellowship, Pfizer Medical Research Merit Award, ARA Senior Rheumatology Scholar Award, Giannini Foundation Medical Research Fellow and Teaching Recognition for Introduction to Clinical Medicine.
An active participant in many organizations, Field has been involved with the American Association for the Advancement of Science
American Association for the Advancement of Science
The American Association for the Advancement of Science is an international non-profit organization with the stated goals of promoting cooperation among scientists, defending scientific freedom, encouraging scientific responsibility, and supporting scientific education and science outreach for the...
, American Association of Immunologists, American College of Physicians, American College of Rheumatology, American Federation of Clinical Research, American Federal for Medical Research, American Society of Histocompatibility & Immunogenetics, American Society of Transplantation, American Society for Clinical Investigation, Central Society for Clinical Research, Clinical Immunology Society, Transplantation Society, and a Diplomate for both the National Board of Medical Examiners and the American Board of Internal Medicine.
In addition, she has written numerous articles for peer-reviewed publications and has a variety of ongoing research support work.