Eric M. Genden
Encyclopedia
Eric M. Genden is an American
otolaryngologist
with the distinction of being the first surgeon
to perform a jaw
transplant
in the United States. It was also the first jaw transplant ever to combine donor jaw with bone marrow
from the patient.
Genden graduated Summa Cum Laude from Columbia College and first in his medical school class. Genden's other achievements include the development of an advancement in tracheal
transplants that allows patients to communicate and breathe normally.
and Immunobiology at Mount Sinai Medical Center in New York City
. He is also the Director of the Head and Neck Cancer Center. His expertise is in thyroid
, parathyroid surgery, head and neck cancer
surgery, and airway reconstruction. Other titles include Professor
(of both Otolaryngology-Head and Neck Surgery and Immunobiology) and Surgical Director of the Multidisciplinary Program for Head and Neck Cancer. He has been funded by the National Institutes of Health for his research in tracheal and laryngeal transplantation.
Memberships include the New York Head and Neck Society, American Head and Neck Society, American Board of Facial Plastic
and Reconstructive Surgery
, and the American Broncho-Esophagological Association. He received his B.A.
degree from Columbia University
in 1987 and graduated from Mount Sinai School of Medicine
in 1992 where he obtained his MD
degree with Distinction in Research.
with tissue from his patient. This innovation minimized the potential for rejection and, equally significantly, allowed the patient to communicate normally post-surgery. Genden has subsequently received international recognition for this work and has been nominated for the Marcus Prize in Medicine.
United States
The United States of America is a federal constitutional republic comprising fifty states and a federal district...
otolaryngologist
Otolaryngology
Otolaryngology or ENT is the branch of medicine and surgery that specializes in the diagnosis and treatment of ear, nose, throat, and head and neck disorders....
with the distinction of being the first surgeon
Surgeon
In medicine, a surgeon is a specialist in surgery. Surgery is a broad category of invasive medical treatment that involves the cutting of a body, whether human or animal, for a specific reason such as the removal of diseased tissue or to repair a tear or breakage...
to perform a jaw
Jaw
The jaw is any opposable articulated structure at the entrance of the mouth, typically used for grasping and manipulating food. The term jaws is also broadly applied to the whole of the structures constituting the vault of the mouth and serving to open and close it and is part of the body plan of...
transplant
Organ transplant
Organ transplantation is the moving of an organ from one body to another or from a donor site on the patient's own body, for the purpose of replacing the recipient's damaged or absent organ. The emerging field of regenerative medicine is allowing scientists and engineers to create organs to be...
in the United States. It was also the first jaw transplant ever to combine donor jaw with bone marrow
Bone marrow
Bone marrow is the flexible tissue found in the interior of bones. In humans, bone marrow in large bones produces new blood cells. On average, bone marrow constitutes 4% of the total body mass of humans; in adults weighing 65 kg , bone marrow accounts for approximately 2.6 kg...
from the patient.
Genden graduated Summa Cum Laude from Columbia College and first in his medical school class. Genden's other achievements include the development of an advancement in tracheal
Vertebrate trachea
In tetrapod anatomy the trachea, or windpipe, is a tube that connects the pharynx or larynx to the lungs, allowing the passage of air. It is lined with pseudostratified ciliated columnar epithelium cells with goblet cells that produce mucus...
transplants that allows patients to communicate and breathe normally.
Biography
Genden is Professor and Chairman of the Department of OtolaryngologyOtolaryngology
Otolaryngology or ENT is the branch of medicine and surgery that specializes in the diagnosis and treatment of ear, nose, throat, and head and neck disorders....
and Immunobiology at Mount Sinai Medical Center in New York City
New York City
New York is the most populous city in the United States and the center of the New York Metropolitan Area, one of the most populous metropolitan areas in the world. New York exerts a significant impact upon global commerce, finance, media, art, fashion, research, technology, education, and...
. He is also the Director of the Head and Neck Cancer Center. His expertise is in thyroid
Thyroid
The thyroid gland or simply, the thyroid , in vertebrate anatomy, is one of the largest endocrine glands. The thyroid gland is found in the neck, below the thyroid cartilage...
, parathyroid surgery, head and neck cancer
Cancer
Cancer , known medically as a malignant neoplasm, is a large group of different diseases, all involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the...
surgery, and airway reconstruction. Other titles include Professor
Professor
A professor is a scholarly teacher; the precise meaning of the term varies by country. Literally, professor derives from Latin as a "person who professes" being usually an expert in arts or sciences; a teacher of high rank...
(of both Otolaryngology-Head and Neck Surgery and Immunobiology) and Surgical Director of the Multidisciplinary Program for Head and Neck Cancer. He has been funded by the National Institutes of Health for his research in tracheal and laryngeal transplantation.
Memberships include the New York Head and Neck Society, American Head and Neck Society, American Board of Facial Plastic
Plastic surgery
Plastic surgery is a medical specialty concerned with the correction or restoration of form and function. Though cosmetic or aesthetic surgery is the best-known kind of plastic surgery, most plastic surgery is not cosmetic: plastic surgery includes many types of reconstructive surgery, hand...
and Reconstructive Surgery
Reconstructive surgery
Reconstructive surgery is, in its broadest sense, the use of surgery to restore the form and function of the body, although Maxillo-Facial Surgeons, Plastic Surgeons and Otolaryngologists do reconstructive surgery on faces after trauma and to reconstruct the head and neck after cancer.Other...
, and the American Broncho-Esophagological Association. He received his B.A.
Bachelor of Arts
A Bachelor of Arts , from the Latin artium baccalaureus, is a bachelor's degree awarded for an undergraduate course or program in either the liberal arts, the sciences, or both...
degree from Columbia University
Columbia University
Columbia University in the City of New York is a private, Ivy League university in Manhattan, New York City. Columbia is the oldest institution of higher learning in the state of New York, the fifth oldest in the United States, and one of the country's nine Colonial Colleges founded before the...
in 1987 and graduated from Mount Sinai School of Medicine
Mount Sinai School of Medicine
Mount Sinai School of Medicine is an American medical school in the borough of Manhattan in New York City, currently ranked among the top 20 medical schools in the United States. It was chartered by Mount Sinai Hospital in 1963....
in 1992 where he obtained his MD
Doctor of Medicine
Doctor of Medicine is a doctoral degree for physicians. The degree is granted by medical schools...
degree with Distinction in Research.
Jaw transplant
In 2006, Genden performed the first jaw transplant in North America, on a patient who carried the donated jaw in one of the back muscles for eight months. Along with several of his surgical team, Genden developed a technology using the patient's bone marrow and donor bony skeleton to create an immunological chimera. This technique has subsequently been applied to solid organ transplantation and Genden and his basic science team have been recognized by the National Academy of Science for this unique contribution to transplantation biology.Tracheal transplant
In 2003, Genden performed the first reported tracheal transplantation that combined donor trachea cartilageCartilage
Cartilage is a flexible connective tissue found in many areas in the bodies of humans and other animals, including the joints between bones, the rib cage, the ear, the nose, the elbow, the knee, the ankle, the bronchial tubes and the intervertebral discs...
with tissue from his patient. This innovation minimized the potential for rejection and, equally significantly, allowed the patient to communicate normally post-surgery. Genden has subsequently received international recognition for this work and has been nominated for the Marcus Prize in Medicine.
Awards, honors and recognition
- "Top Doctor" in Castle Connolly (2006, 2007, 2008, 2009, 2010)
- "Top Thyroid Doctor,"(2006, 2007, 2008, 2009, 2010) Thyroid-Info.com
- Best Clinical Innovations Award: The use of OsseointegratedOsseointegrationOsseointegration derives from the Greek osteon, bone, and the Latin integrare, to make whole. The term refers to the direct structural and functional connection between living bone and the surface of a load-bearing artificial implant...
Implants in Maxillary Reconstruction, Academy of Osseointegration, Boston, MA. 2003. - American Academy of Otolaryngology-Head and Neck Surgery's Honor Award, 2003.
- Educator of the Year Award, Mount Sinai School of Medicine, Department of Otolaryngology-Head and Neck Surgery, 2003
- First Place, 2002 New York Academy of SciencesNew York Academy of SciencesThe New York Academy of Sciences is the third oldest scientific society in the United States. An independent, non-profit organization with more than members in 140 countries, the Academy’s mission is to advance understanding of science and technology...
Resident Research Program Presentation - 1998 Excellence in Teaching Award, Washington University in St. LouisWashington University in St. LouisWashington University in St. Louis is a private research university located in suburban St. Louis, Missouri. Founded in 1853, and named for George Washington, the university has students and faculty from all fifty U.S. states and more than 110 nations...
- Award for Outstanding Resident Research in Basic Science, 1997
- American Academy of Otolaryngic Allergy Award, 1996
- American Society for Peripheral Nerve Research Award, 1996
- Foundation Research Award, 1996.
- Hewlett-PackardHewlett-PackardHewlett-Packard Company or HP is an American multinational information technology corporation headquartered in Palo Alto, California, USA that provides products, technologies, softwares, solutions and services to consumers, small- and medium-sized businesses and large enterprises, including...
Award for the Top Medical Graduate, 1992 - The Nathan A. Selz Prize for Outstanding Achievement in Research
- American Federation for Clinical Research Student Award, 1992
- Alpha Omega AlphaAlpha Omega AlphaThe Alpha Omega Alpha Honor Medical Society, commonly called Alpha Omega Alpha and abbreviated ΑΩΑ or AOA, is a national honor society for medical students, residents, scientists and physicians in the United States and Canada.-History:...
Honor Society June, 1992
Books
- Genden EM, Varvares M. Head and Neck Cancer: An Evidence-Based Team Approach. Thieme, New York, New York; First Edition, 2008 ISBN 158890508X
- Genden EM. Microvascular Free-Tissue Transfer: The Anatomy and Application of Free Flaps in Contemporary Head and Neck Reconstruction. American Academy of OtolaryngologyAmerican Academy of OtolaryngologyThe American Academy of Otolaryngology - Head and Neck Surgery, originally started in the 1924, is the world's largest organization of over 13,000 specialist related to the area of ears, nose, and throat.- History :Reference...
- Head & Neck, 2006 ISBN 1567720986
- Genden EM. Contemporary Management of Head and Neck Tumors. Thieme, New York, New York; First Edition, in preparation.
- Urken ML, Buchbinder D, Okay D, Genden EM. Reconstruction of the Head and Neck: A Defect-Oriented Approach. Raven Press, New York, New York; First Edition, in preparation.
Other Publications (partial list)
- A rare prevertebral ordinary lipoma presenting as obstructive sleep apnea: computed tomographic and magnetic resonance imaging findings. Eloy JA, Carneiro E, Vibhute P, Genden EM, Bederson JBJoshua B. BedersonJoshua B. Bederson, M.D., is a neurosurgeon and Professor and Chief of Neurosurgery at the Mount Sinai Medical Center in New York City. He is a Fellow of the American College of Surgeons and an attending neurosurgeon at both Mount Sinai and Elmhurst Hospital in Elmhurst, Queens.Bederson is...
, Som PM. " Arch Otolaryngol Head Neck Surg. 2008 Sep. PMID 18794447
- Oral squamous cell carcinoma: histologic risk assessment, but not margin status, is strongly predictive of local diseasefree and overall survival. Brandwein-Gensler M, Teixeira MS, Lewis CM, Lee B, Rolnitzky L, Hille JJ, Genden E, Urken ML, Wang BY. Am J Surg Pathol.The American Journal of Surgical PathologyThe American Journal of Surgical Pathology is a leading journal in field of surgical pathology. It was first published in 1977. Its first Editor-in-Chief was Stephen Sternberg of the Memorial Sloan-Kettering Cancer Center.-External links: - www.ajsp.com....
2005 PMID 15644773
- Treatment considerations for head and neck cancer in the elderly. Genden EM, Rinaldo A, Shaha AR, Clayman GL, Werner JA, Suarez C, Ferlito A. J Laryngol Otol., 2005 PMID 15845185
- Reepithelialized orthotopic tracheal allografts expand memory cytotoxic T lymphocytes but show no evidence of chronic rejection. Cleven HA, Genden EM, Moran TM. Transplantation, 2005 PMID 12525206
- Is there a role for selective neck dissection after chemoradiation for head and neck cancer? Robbins KT, Ferlito A, Suarez C, Brizel DM, Bradley PJ, Pellitteri PK, Clayman GL, Kowalski LP, Genden EM, Rinaldo A. J Am Coll Surg., 2004 PMID 15555975
- Pharyngocutaneous fistula following laryngectomy. Genden EM, Rinaldo A, Shaha AR, Bradley PJ, Rhys-Evans PH, Ferlito A. Acta Otolaryngol.Acta OncologicaActa Oncologica is the official journal of the five Nordic oncological societies. The members of the editorial committee represent these societies.Acta Oncologica is a scientific medical journal within clinical oncology and related disciplines...
, 2004 PMID 15072411
- Primary sphenoid sinus esthesioneuroblastoma. Morris L, Govindaraj S, Genden EM. Am J Otolaryngol., 2004 PMID 15334400
- Complications of free flap transfers for head and neck reconstruction following cancer resection. Genden EM, Rinaldo A, Suarez C, Wei WI, Bradley PJ, Ferlito A. Oral Oncol., 2004 PMID 15509488
- Effect of fibrin matrix and vascular endothelial growth factor on reepithelialization of orthotopic murine tracheal transplants. Govindaraj S, Gordon R, Genden EM. Ann Otol Rhinol Laryngol., 2004 PMID 15535142
- Reconstruction of the hard palate with the radial forearm free flap: Outcomes and Quality of Life. Wallace D, Genden EM, Urken ML. Head and Neck, 2004 PMID 15350027
- Sensory topography of the oral cavity and the impact of free flap reconstruction: A preliminary study. Zur KB, Genden EM, Urken ML. Head and Neck, 2004 PMID 15390196
- Prediction of Postoperative Hypocalcemia after Thyroid Surgery using a Rapid Intraoperative Parathyroid Hormone Assay. Mandell DL, Genden EM, Mechanick JI, Bergman DA, Urken ML. Arch Otolaryngol Head Neck Surg., 2004