• Jay O'Brien (Virginia politician)
  Jay O'Brien (Virginia politician)
  James Kenneth "Jay" O'Brien Jr. was a Republican member of the Virginia Senate, representing the 39th District from 2003 through 2007. Previously he was a Delegate of the Virginia House of Delegates from 1993 through 2002...
  
   (born 1951), Virginia politician
• James O'Brien (Canadian politician)
  James O'Brien (Canadian politician)
  James O'Brien was a Canadian merchant, wholesaler, and politician.Born in Aughnagar, County Tyrone, Ireland, O'Brien was educated there and moved to Canada in 1850. In 1858, he started business in the wholesale clothing and dry goods trade in Montreal. He retired from that business in 1893...
  
   (1836–1903), Canadian senator
• James Francis Xavier O'Brien (1828–1905) Irish rebel and UK MP
• James O'Brien (1695–1771)
  James O'Brien (1695–1771)
  Hon. James O'Brien was an Irish nobleman and politician.-Life:James O'Brien was the son of William O'Brien, 3rd Earl of Inchiquin, and his wife, Mary Villiers. He was born in 1695 at Inchiquin, County Clare. Not long after his birth, his family relocated to Charleville, County Cork...
  
  , Irish nobleman and politician
• James O'Brien (1806–1881) , Irish Judge and UK MP for Limerick City
  Limerick City (UK Parliament constituency)
  Limerick City was a United Kingdom Parliament constituency, in Ireland. It returned one MP 1801–1832, two MPs 1832–1885 and one thereafter. It was an original constituency represented in Parliament when the Union of Great Britain and Ireland took effect on 1 January 1801...
  
   1854–1858
• James O'Brien (horticulturalist) (1842–1930), winner of the Victoria Medal of Honour
  Victoria Medal of Honour
  The Victoria Medal of Honour is awarded to British horticulturists resident in the United Kingdom whom the Royal Horticultural Society Council considers deserving of special honour by the Society...
  
  
• James O'Brien (New Zealand)
  James O'Brien (New Zealand)
  James O’Brien was a New Zealand politician of the Labour Party.He represented the Westland seat in Parliament from 1922, when he defeated Tom Seddon...
  
   (1875–1947), New Zealand politician
• James O'Brien (U.S. Congressman)
  James O'Brien (U.S. Congressman)
  James O'Brien of New York City, born in Ireland, was a U.S. Representative from New York from 1879 to 1881.James O'Brien was born in County Kings, Ireland on March 13, 1841. He attended the common schools, then immigrated to the United States in 1861. He served as alderman of New York City in...
  
   (1841–1907), United States Representative from New York
• James O'Brien (radio presenter) (born 1972), British radio presenter and journalist
• James O'Brien (internet radio) (born 1973), founder and producer of RantMedia
• James O'Brien (footballer) (born 1987), Scots-born Irish football player
• James Bronterre O'Brien
  James Bronterre O'Brien
  James Bronterre O'Brien was an Irish Chartist leader, reformer and journalist.- Irish Birth & Formative Years :James O'Brien, was born near Granard, County Longford, Ireland in 1804 or 1805...
  
   (died 1864), Irish-born Chartist leader, reformer and journalist
• James F. O'Brien
  James F. O'Brien
  James F. O'Brien is a computer graphics researcher and associate professor of Computer Science and Electrical Engineering at the University of California, Berkeley.-Education:...
  
  , American computer graphics researcher
• James H. O'Brien
  James H. O'Brien
  James Henry O'Brien of Brooklyn, New York was a U.S. Representative from New York from 1913 to 1915. He was a Democrat.-References:...
  
   (1860–1924), United States Representative from New York
• James O'Brien, 3rd Marquess of Thomond
  James O'Brien, 3rd Marquess of Thomond
  Admiral James McEdward O'Brien, 3rd Marquess of Thomond, GCH , styled Lord James O'Brien from 1809 to 1846, was a British naval officer....
  
   (1769–1855), British naval officer
• James O'Brien (New Brunswick politician)
  James O'Brien (New Brunswick politician)
  James O'Brien was a blacksmith and political figure in New Brunswick, Canada. He represented Charlotte County in the Legislative Assembly of New Brunswick from 1892 to 1903 as a Liberal member....
  
   (1824–1922), blacksmith and political figure in New Brunswick, Canada
• James O'Brien (hurler)
  James O'Brien (hurler)
  James O'Brien is an Irish sportsperson. He plays hurling with his local club Bruree and has been a member of the Limerick and Kerry senior inter-county teams at various times since 2003. In 2007 he helped Tralee IT win the Ryan Cup and won a Higher Education All Star the only player outside the...
  
   (born 1983), Irish hurler
• James O'Brien, Australian musician, bassist for The Boat People

See also

• Jamie O'Brien (disambiguation)
• Jim O'Brien (disambiguation)