Karl Gottfried Paul Döhle
Encyclopedia
Karl Gottfried Paul Döhle (June 6, 1855 – December 7, 1928) was a German pathologist who was a native of Mühlhausen
.
He was a student at Tübingen
, Leipzig
, Strassburg and Kiel
, where he received his doctorate in 1882. Afterwards he was an assistant at the pathological institute in Kiel, and in 1908 was appointed head of the pathological institute. In 1921 he attained the title of professor ordinarius (full professor) at the University of Kiel
, retiring a few years later in 1924.
Döhle is remembered for his work in the field of histopathology
, particularly in his research of syphilitic
inflammation of the aorta
. He is credited with being the first physician to describe the histology
of syphilitic aortitis
. A sometimes-used synonym of syphilitic aortitis is "Döhle-Heller aortitis", named after Döhle and Arnold Ludwig Gotthilf Heller
(1840-1913); Döhle's mentor in Kiel.
He is also known for the discovery of small (1-3 µ in diameter) light blue-gray basophilic
leukocyte inclusions in the periphery of neutrophils, that are known today as "Döhle bodies
".
Mühlhausen
Mühlhausen is a city in the federal state of Thuringia, Germany. It is the capital of the Unstrut-Hainich district, and lies along the river Unstrut. Mühlhausen had c. 37,000 inhabitants in 2006.-History:...
.
He was a student at Tübingen
Tübingen
Tübingen is a traditional university town in central Baden-Württemberg, Germany. It is situated south of the state capital, Stuttgart, on a ridge between the Neckar and Ammer rivers.-Geography:...
, Leipzig
Leipzig
Leipzig Leipzig has always been a trade city, situated during the time of the Holy Roman Empire at the intersection of the Via Regia and Via Imperii, two important trade routes. At one time, Leipzig was one of the major European centres of learning and culture in fields such as music and publishing...
, Strassburg and Kiel
Kiel
Kiel is the capital and most populous city in the northern German state of Schleswig-Holstein, with a population of 238,049 .Kiel is approximately north of Hamburg. Due to its geographic location in the north of Germany, the southeast of the Jutland peninsula, and the southwestern shore of the...
, where he received his doctorate in 1882. Afterwards he was an assistant at the pathological institute in Kiel, and in 1908 was appointed head of the pathological institute. In 1921 he attained the title of professor ordinarius (full professor) at the University of Kiel
University of Kiel
The University of Kiel is a university in the city of Kiel, Germany. It was founded in 1665 as the Academia Holsatorum Chiloniensis by Christian Albert, Duke of Holstein-Gottorp and has approximately 23,000 students today...
, retiring a few years later in 1924.
Döhle is remembered for his work in the field of histopathology
Histopathology
Histopathology refers to the microscopic examination of tissue in order to study the manifestations of disease...
, particularly in his research of syphilitic
Syphilis
Syphilis is a sexually transmitted infection caused by the spirochete bacterium Treponema pallidum subspecies pallidum. The primary route of transmission is through sexual contact; however, it may also be transmitted from mother to fetus during pregnancy or at birth, resulting in congenital syphilis...
inflammation of the aorta
Aorta
The aorta is the largest artery in the body, originating from the left ventricle of the heart and extending down to the abdomen, where it branches off into two smaller arteries...
. He is credited with being the first physician to describe the histology
Histology
Histology is the study of the microscopic anatomy of cells and tissues of plants and animals. It is performed by examining cells and tissues commonly by sectioning and staining; followed by examination under a light microscope or electron microscope...
of syphilitic aortitis
Syphilitic aortitis
Syphilitic aortitis is a disease of the aorta associated with the tertiary stage of syphilis infection. SA begins as inflammation of the adventia, including the vessels that supply the aorta itself with blood, the vasa vasorum...
. A sometimes-used synonym of syphilitic aortitis is "Döhle-Heller aortitis", named after Döhle and Arnold Ludwig Gotthilf Heller
Arnold Ludwig Gotthilf Heller
Arnold Ludwig Gotthilf Heller was a German anatomist and pathologist who was a native of Kleinheubach am Main, Bavaria.He studied medicine at the Universities of Erlangen, Berlin and Leipzig, and as a student had as instructors Friedrich Albert von Zenker , Carl Ludwig and Rudolf Virchow...
(1840-1913); Döhle's mentor in Kiel.
He is also known for the discovery of small (1-3 µ in diameter) light blue-gray basophilic
Basophilic
Basophilic is a technical term used by histologists. It describes the microscopic appearance of cells and tissues, as seen down the microscope, after a histological section has been stained with a basic dye. The most common such dye is haematoxylin....
leukocyte inclusions in the periphery of neutrophils, that are known today as "Döhle bodies
Döhle bodies
Döhle bodies are light blue-gray, oval, basophilic, leukocyte inclusions located in the peripheral cytoplasm of neutrophils. They measure 1-3 µm in diameter...
".
Selected writings
- Ein Fall von eigentümlicher Aortenerkrankung bei einem Syphilitischen. (Treatise on syphilitic aortitis), Kiel, 1885.
- Vorläufige Mittheilung über Blutbefunde bei Masern. (Paper on Döhle bodies), Zentralblatt für allgemeine Pathologie und pathologische Anatomie, Jena, 1892, 3: 150-152