Liebermeister's rule concerns the increment ratio between and adult individual's cardiac frequency and temperature when in fever. Each Celsius grade of body temperature

Thermoregulation

Thermoregulation is the ability of an organism to keep its body temperature within certain boundaries, even when the surrounding temperature is very different...

 increment corresponds to an 8 beats per minute in cardiac frequency. An exception to this rule by creating a relative bradycardia

Bradycardia

Bradycardia , in the context of adult medicine, is the resting heart rate of under 60 beats per minute, though it is seldom symptomatic until the rate drops below 50 beat/min. It may cause cardiac arrest in some patients, because those with bradycardia may not be pumping enough oxygen to their heart...

 is known as Faget sign

Faget sign

In medicine, the Faget sign is the unusual constellation of fever and bradycardia . It is often seen in yellow fever.Fever is usually accompanied by tachycardia , an association known by the eponym Liebermeister's rule....

 (pulse-temperature dissociation) common in some diseases, especially yellow fever

Yellow fever

Yellow fever is an acute viral hemorrhagic disease. The virus is a 40 to 50 nm enveloped RNA virus with positive sense of the Flaviviridae family....

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It is named for Carl von Liebermeister

Carl von Liebermeister

Carl von Liebermeister was a German internist who was a native of Ronsdorf. In 1856 he received his medical degree from Greifswald, and in 1860 became an assistant to Felix von Niemeyer at the University of Tübingen. In 1864 he became a professor of pathology in Basel, and in 1871 succeeded Dr...

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