Ramachandra S. Hosmane
Encyclopedia
Ramachandra "" S. Hosmane (1944-) is a retired Senior Professor of Organic Chemistry at University of Maryland, Baltimore County. Dr. Hosmane has over 150 peer-reviewed research publications in reputed international journals. He holds four U.S. patents, three of which have been licensed to industries. His contributions to the field of Organic Chemistry
and medicinal chemistry
are notable. He has trained well over 100 undergraduate students, 30 graduate students, and 20 postdoctoral fellows and visiting scientists in his laboratory. His current research focus is on drug discovery for dual inhibition of HCV
and HIV
as well as lung, breast, and prostate cancers.
, Uttar Kannada, India
and completed Bhadrakali High School, Gokarna
. In 1966, he earned a B.Sc in Chemistry from Karnataka University, Dharwar, followed by a M.Sc. degree in Organic Chemistry
from the same institution in 1968.
in the early 1970s to pursue a doctoral degree in organic synthesis
and medicinal chemistry
at the University of South Florida
, where he earned M.S.
(1976) and Ph.D.
degrees (1978). After completing his postdoctoral training (1979–82) at the University of Illinois, Urbana-Champaign, Hosmane joined UMBC as an Assistant Professor in 1982 and was promoted to Associate Professor with academic tenure in 1986. He was promoted to the rank of full Professor in 1994.
His research work has been supported by about 50 grants from federal and state agencies such as the National Institutes of Health
and the Maryland Industrial Partnerships (MIPS), and private foundations such as the American Heart Association
, American Cancer Society
, and the Petroleum Research Fund as well as a variety of industrial sources. He has contributed significantly to the development of organic
and medicinal chemistry
.
Hosmane was awarded the Presidential Teaching Professorship for years 2009-2012 from UMBC. He was earlier recognized as the Maryland Chemist of the Year by the American Chemical Society
, Maryland Division, in 2002. In 2001, he was awarded the Outstanding Educator of the Year Award from the Maryland Association for Higher Education (MAHE). He was also honored as the University Presidential Research Professor for years 1998-2001. In 1996, he was recognized as Outstanding Mentor of Project SEED of the American Chemical Society. In 1999, he was given honorary faculty membership in the Golden Key International Honor Society. He has been a consistent member of the NIH Scientific Review Groups, serving on a wide variety of NIH grant review panels generally referred to as Study Sections. He is also a reviewer for U.S.Food and Drug Administration
(FDA)'s intramural scientific programs.
Two major research areas of Hosmane include blood substitutes
based on hemoglobins and the discovery of antiviral
and anticancer compounds based on ring-expanded nucleoside structures. The compounds synthesized in his laboratory have shown potent activities against a wide variety of viruses and cancers, including the hepatitis B (HBV) and hepatitis C
(HCV) viruses, human immunodeficiency virus (HIV), the West Nile virus
(WNV), the Japanese encephalitis virus (JEV), the measles virus, the rhino virus , the Varicella zoster virus
(VZV), Epstein-Barr virus
, respiratory syncytial virus (RSV), influenza
viruses A & B, Herpes Simplex
viruses as well as prostate cancer
, lung cancer
, breast cancer
, colon cancer, and leukemia
. His current research focus is on drug discovery for dual inhibition of HCV
and HIV
as well as lung, breast, and prostate cancers.
Hosmane is a Managing Editor, Current Topics in Medicinal Chemistry; Frontiers in Bioscience Regional Editor, Molecules. He acted as peer reviewer forNIH, NSF
, American Heart Association
, Research Corporation
, Guggenheim Foundation
; Journals: JACS, JOC, Tet. Lett., J.Het.Chem., J. Med. Chem., Synthesis, Chem. Ber., Liebigs Ann. Chem., Nucleosides & Nucleotides, Nucl. Acids Res., J. Biomol.Struct. Dyn., Tetrahedron, Angewandte Chemie, Eur. J. Org. Chem., Hemoglobin, Bioorg. Med. Chem., Bioorg. Med. Chem. Lett.
He is a member of Sigma Xi; Affiliate IUPAC, Am. Chem. Soc., Chem. Soc.(London), Internat. Soc. Heterocycl. Chem., Internat. Soc. Antiviral Research, and American Assoc. Adv. Science.
Dr. Hosmane is married to Raji. They have one daughter Mala.
Organic chemistry
Organic chemistry is a subdiscipline within chemistry involving the scientific study of the structure, properties, composition, reactions, and preparation of carbon-based compounds, hydrocarbons, and their derivatives...
and medicinal chemistry
Medicinal chemistry
Medicinal chemistry and pharmaceutical chemistry are disciplines at the intersection of chemistry, especially synthetic organic chemistry, and pharmacology and various other biological specialties, where it is involved with design, chemical synthesis and development for market of pharmaceutical...
are notable. He has trained well over 100 undergraduate students, 30 graduate students, and 20 postdoctoral fellows and visiting scientists in his laboratory. His current research focus is on drug discovery for dual inhibition of HCV
HCV
HCV may mean the following:*Hepatitis C virus*Human Coronavirus*Hypersonic Cruise Vehicle, a target for DARPA's FALCON program*Heavy commercial vehicle*Higher Calorific Value...
and HIV
HIV
Human immunodeficiency virus is a lentivirus that causes acquired immunodeficiency syndrome , a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive...
as well as lung, breast, and prostate cancers.
Early life
Ram Hosmane was born in GokarnaGokarna
Gokarna is a village in the Uttara Kannada district of the Karnataka state, India. It is a Hindu pilgrimage centre as well as a tourist destination in India. Gokarna is a temple town and is referred to in a number of Hindu historical literature pieces. The main deity is Lord Mahabhaleshwara, a...
, Uttar Kannada, India
India
India , officially the Republic of India , is a country in South Asia. It is the seventh-largest country by geographical area, the second-most populous country with over 1.2 billion people, and the most populous democracy in the world...
and completed Bhadrakali High School, Gokarna
Bhadrakali High School, Gokarna
Bhadrakali High School, Gokarna is one of the oldest high schools in Kumta taluk, Uttar Kannada district. Bhadrkali is the name of the Hindu Goddess Kali. The school is named after the Goddess Kali....
. In 1966, he earned a B.Sc in Chemistry from Karnataka University, Dharwar, followed by a M.Sc. degree in Organic Chemistry
Organic chemistry
Organic chemistry is a subdiscipline within chemistry involving the scientific study of the structure, properties, composition, reactions, and preparation of carbon-based compounds, hydrocarbons, and their derivatives...
from the same institution in 1968.
Career
Hosmane moved to the United StatesUnited States
The United States of America is a federal constitutional republic comprising fifty states and a federal district...
in the early 1970s to pursue a doctoral degree in organic synthesis
Organic synthesis
Organic synthesis is a special branch of chemical synthesis and is concerned with the construction of organic compounds via organic reactions. Organic molecules can often contain a higher level of complexity compared to purely inorganic compounds, so the synthesis of organic compounds has...
and medicinal chemistry
Medicinal chemistry
Medicinal chemistry and pharmaceutical chemistry are disciplines at the intersection of chemistry, especially synthetic organic chemistry, and pharmacology and various other biological specialties, where it is involved with design, chemical synthesis and development for market of pharmaceutical...
at the University of South Florida
University of South Florida
The University of South Florida, also known as USF, is a member institution of the State University System of Florida, one of the state's three flagship universities for public research, and is located in Tampa, Florida, USA...
, where he earned M.S.
Master of Science
A Master of Science is a postgraduate academic master's degree awarded by universities in many countries. The degree is typically studied for in the sciences including the social sciences.-Brazil, Argentina and Uruguay:...
(1976) and Ph.D.
Ph.D.
A Ph.D. is a Doctor of Philosophy, an academic degree.Ph.D. may also refer to:* Ph.D. , a 1980s British group*Piled Higher and Deeper, a web comic strip*PhD: Phantasy Degree, a Korean comic series* PhD Docbook renderer, an XML renderer...
degrees (1978). After completing his postdoctoral training (1979–82) at the University of Illinois, Urbana-Champaign, Hosmane joined UMBC as an Assistant Professor in 1982 and was promoted to Associate Professor with academic tenure in 1986. He was promoted to the rank of full Professor in 1994.
His research work has been supported by about 50 grants from federal and state agencies such as the National Institutes of Health
National Institutes of Health
The National Institutes of Health are an agency of the United States Department of Health and Human Services and are the primary agency of the United States government responsible for biomedical and health-related research. Its science and engineering counterpart is the National Science Foundation...
and the Maryland Industrial Partnerships (MIPS), and private foundations such as the American Heart Association
American Heart Association
The American Heart Association is a non-profit organization in the United States that fosters appropriate cardiac care in an effort to reduce disability and deaths caused by cardiovascular disease and stroke. It is headquartered in Dallas, Texas...
, American Cancer Society
American Cancer Society
The American Cancer Society is the "nationwide community-based voluntary health organization" dedicated, in their own words, "to eliminating cancer as a major health problem by preventing cancer, saving lives, and diminishing suffering from cancer, through research, education, advocacy, and...
, and the Petroleum Research Fund as well as a variety of industrial sources. He has contributed significantly to the development of organic
Organic chemistry
Organic chemistry is a subdiscipline within chemistry involving the scientific study of the structure, properties, composition, reactions, and preparation of carbon-based compounds, hydrocarbons, and their derivatives...
and medicinal chemistry
Medicinal chemistry
Medicinal chemistry and pharmaceutical chemistry are disciplines at the intersection of chemistry, especially synthetic organic chemistry, and pharmacology and various other biological specialties, where it is involved with design, chemical synthesis and development for market of pharmaceutical...
.
Hosmane was awarded the Presidential Teaching Professorship for years 2009-2012 from UMBC. He was earlier recognized as the Maryland Chemist of the Year by the American Chemical Society
American Chemical Society
The American Chemical Society is a scientific society based in the United States that supports scientific inquiry in the field of chemistry. Founded in 1876 at New York University, the ACS currently has more than 161,000 members at all degree-levels and in all fields of chemistry, chemical...
, Maryland Division, in 2002. In 2001, he was awarded the Outstanding Educator of the Year Award from the Maryland Association for Higher Education (MAHE). He was also honored as the University Presidential Research Professor for years 1998-2001. In 1996, he was recognized as Outstanding Mentor of Project SEED of the American Chemical Society. In 1999, he was given honorary faculty membership in the Golden Key International Honor Society. He has been a consistent member of the NIH Scientific Review Groups, serving on a wide variety of NIH grant review panels generally referred to as Study Sections. He is also a reviewer for U.S.Food and Drug Administration
Food and Drug Administration
The Food and Drug Administration is an agency of the United States Department of Health and Human Services, one of the United States federal executive departments...
(FDA)'s intramural scientific programs.
Two major research areas of Hosmane include blood substitutes
Blood substitutes
A blood substitute is a substance used to mimic and fulfill some functions of biological blood, usually in the oxygen-carrying sense...
based on hemoglobins and the discovery of antiviral
Antiviral
Antiviral may refer to:*Antiviral drug*Antiviral protein*Antivirus software*Antiviral Therapy, an academic journal...
and anticancer compounds based on ring-expanded nucleoside structures. The compounds synthesized in his laboratory have shown potent activities against a wide variety of viruses and cancers, including the hepatitis B (HBV) and hepatitis C
Hepatitis C
Hepatitis C is an infectious disease primarily affecting the liver, caused by the hepatitis C virus . The infection is often asymptomatic, but chronic infection can lead to scarring of the liver and ultimately to cirrhosis, which is generally apparent after many years...
(HCV) viruses, human immunodeficiency virus (HIV), the West Nile virus
West Nile virus
West Nile virus is a virus of the family Flaviviridae. Part of the Japanese encephalitis antigenic complex of viruses, it is found in both tropical and temperate regions. It mainly infects birds, but is known to infect humans, horses, dogs, cats, bats, chipmunks, skunks, squirrels, domestic...
(WNV), the Japanese encephalitis virus (JEV), the measles virus, the rhino virus , the Varicella zoster virus
Varicella zoster virus
Varicella zoster virus is one of eight herpes viruses known to infect humans . It commonly causes chicken-pox in children and Herpes zoster in adults and rarely in children.-Nomenclature:...
(VZV), Epstein-Barr virus
Epstein-Barr virus
The Epstein–Barr virus , also called human herpesvirus 4 , is a virus of the herpes family and is one of the most common viruses in humans. It is best known as the cause of infectious mononucleosis...
, respiratory syncytial virus (RSV), influenza
Influenza
Influenza, commonly referred to as the flu, is an infectious disease caused by RNA viruses of the family Orthomyxoviridae , that affects birds and mammals...
viruses A & B, Herpes Simplex
Herpes simplex
Herpes simplex is a viral disease caused by both Herpes simplex virus type 1 and type 2 . Infection with the herpes virus is categorized into one of several distinct disorders based on the site of infection. Oral herpes, the visible symptoms of which are colloquially called cold sores or fever...
viruses as well as prostate cancer
Prostate cancer
Prostate cancer is a form of cancer that develops in the prostate, a gland in the male reproductive system. Most prostate cancers are slow growing; however, there are cases of aggressive prostate cancers. The cancer cells may metastasize from the prostate to other parts of the body, particularly...
, lung cancer
Lung cancer
Lung cancer is a disease characterized by uncontrolled cell growth in tissues of the lung. If left untreated, this growth can spread beyond the lung in a process called metastasis into nearby tissue and, eventually, into other parts of the body. Most cancers that start in lung, known as primary...
, breast cancer
Breast cancer
Breast cancer is cancer originating from breast tissue, most commonly from the inner lining of milk ducts or the lobules that supply the ducts with milk. Cancers originating from ducts are known as ductal carcinomas; those originating from lobules are known as lobular carcinomas...
, colon cancer, and leukemia
Leukemia
Leukemia or leukaemia is a type of cancer of the blood or bone marrow characterized by an abnormal increase of immature white blood cells called "blasts". Leukemia is a broad term covering a spectrum of diseases...
. His current research focus is on drug discovery for dual inhibition of HCV
HCV
HCV may mean the following:*Hepatitis C virus*Human Coronavirus*Hypersonic Cruise Vehicle, a target for DARPA's FALCON program*Heavy commercial vehicle*Higher Calorific Value...
and HIV
HIV
Human immunodeficiency virus is a lentivirus that causes acquired immunodeficiency syndrome , a condition in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive...
as well as lung, breast, and prostate cancers.
Hosmane is a Managing Editor, Current Topics in Medicinal Chemistry; Frontiers in Bioscience Regional Editor, Molecules. He acted as peer reviewer forNIH, NSF
National Science Foundation
The National Science Foundation is a United States government agency that supports fundamental research and education in all the non-medical fields of science and engineering. Its medical counterpart is the National Institutes of Health...
, American Heart Association
American Heart Association
The American Heart Association is a non-profit organization in the United States that fosters appropriate cardiac care in an effort to reduce disability and deaths caused by cardiovascular disease and stroke. It is headquartered in Dallas, Texas...
, Research Corporation
Research Corporation
The Research Corporation for Science Advancement is an organization in the United States devoted to the advancement of science, funding research projects in the physical sciences. It was also a major supporter of the research that led to the presentation of Interlingua in 1951...
, Guggenheim Foundation
John Simon Guggenheim Memorial Foundation
The John Simon Guggenheim Memorial Foundation was founded in 1925 by Mr. and Mrs. Simon Guggenheim in memory of their son, who died April 26, 1922...
; Journals: JACS, JOC, Tet. Lett., J.Het.Chem., J. Med. Chem., Synthesis, Chem. Ber., Liebigs Ann. Chem., Nucleosides & Nucleotides, Nucl. Acids Res., J. Biomol.Struct. Dyn., Tetrahedron, Angewandte Chemie, Eur. J. Org. Chem., Hemoglobin, Bioorg. Med. Chem., Bioorg. Med. Chem. Lett.
He is a member of Sigma Xi; Affiliate IUPAC, Am. Chem. Soc., Chem. Soc.(London), Internat. Soc. Heterocycl. Chem., Internat. Soc. Antiviral Research, and American Assoc. Adv. Science.
Dr. Hosmane is married to Raji. They have one daughter Mala.