The Rubella virus 3' cis-acting element RNA

RNA

Ribonucleic acid , or RNA, is one of the three major macromolecules that are essential for all known forms of life....

 family represents a cis-acting element found at the 3' UTR in the rubella virus

Rubella virus

Rubella virus is the pathogenic agent of the disease Rubella, and is the cause of congenital rubella syndrome when infection occurs during the first weeks of lunacy.Humans are the only known host of this virus....

. This family contains three conserved step loop structures. Calreticulin

Calreticulin

Calreticulin also known as calregulin, CRP55, CaBP3, calsequestrin-like protein, and endoplasmic reticulum resident protein 60 is a protein that in humans is encoded by the CALR gene....

 (CAL), which is known to bind calcium in most eukaryotic cells, is able to specifically bind to the first stem loop of this RNA. CAL binding is thought to be related to viral pathogenesis

Pathogenesis

The pathogenesis of a disease is the mechanism by which the disease is caused. The term can also be used to describe the origin and development of the disease and whether it is acute, chronic or recurrent...

 and in particular arthritis

Arthritis

Arthritis is a form of joint disorder that involves inflammation of one or more joints....

 which is a occurs frequently in rubella infections in adults and is independent of viral viability

Viability

Viable or viability is the ability of a thing to maintain itself or recover its potentialities.Viable or viability may also refer to:...

. All stem loop structures are thought to be important for efficient viral replication and deletion of stem loop three is known to be lethal.