Sir Edward O'Brien, 2nd Baronet (7 April 1705 – 26 November 1765) was an Irish politician and baronet.

He was the son of Lucius O'Brien, son of Sir Donough O'Brien, 1st Baronet

Sir Donough O'Brien, 1st Baronet

Sir Donough O'Brien, 1st Baronet was an Irish politician and baronet.He was the son of Connor O'Brien and his wife Mary McMahon. In 1692, O'Brien entered the Irish House of Commons, sitting for Clare until 1714....

, and his wife Catherine Keightly. O'Brien married Mary Hickman, daughter of Hugh Hickman and together they had the following children:

• Donough O'Brien
• Edward O'Brien
• Catherine O'Brien married Charles MacDonnell Esq. of Kilkee, county Clare. d 1773
• Sir Lucius O'Brien, 3rd Baronet
  Sir Lucius O'Brien, 3rd Baronet
  Sir Lucius Henry O'Brien, 3rd Baronet PC was an Irish baronet and politician for 34 years.-Background:...
  
  .

He entered the Irish House of Commons

Irish House of Commons

The Irish House of Commons was the lower house of the Parliament of Ireland, that existed from 1297 until 1800. The upper house was the House of Lords...

 in 1727, sitting for Clare

Clare (Parliament of Ireland constituency)

Clare was a constituency represented in the Irish House of Commons until 1800.-History:In the Patriot Parliament of 1689 summoned by King James II, Clare was represented with two members.-Members of Parliament:* 1583 Sir Turlogh O’Brien, Ennistymon....

, the same constituency his grandfather had also represented, until his death in 1765.