U.S. Route 378 is a spur of U.S. Route 78

U.S. Route 78

U.S. Highway 78 is an east–west United States highway that runs for 715 miles from Memphis, Tennessee, to Charleston, South Carolina. Between Memphis and Birmingham, Alabama, it is being upgraded to become Interstate 22....

. It currently runs for 234 miles (377 km) from Conway, South Carolina

Conway, South Carolina

Conway is a city in Horry County, South Carolina, United States. The population was 16,317 at the 2010 census. It is the county seat of Horry County and is part of the Myrtle Beach metropolitan area. It is the home of Coastal Carolina University....

 at U.S. Route 501

U.S. Route 501

-North Carolina business loops:-Virginia business loop:-External links:*...

 to Washington, Georgia

Washington, Georgia

Washington is a city in Wilkes County, Georgia, United States. The population was 4,295 at the 2000 census. The city is the county seat of Wilkes County...

 at U.S. Route 78

U.S. Route 78

U.S. Highway 78 is an east–west United States highway that runs for 715 miles from Memphis, Tennessee, to Charleston, South Carolina. Between Memphis and Birmingham, Alabama, it is being upgraded to become Interstate 22....

.

Route description

It passes through the states of South Carolina

South Carolina

South Carolina is a state in the Deep South of the United States that borders Georgia to the south, North Carolina to the north, and the Atlantic Ocean to the east. Originally part of the Province of Carolina, the Province of South Carolina was one of the 13 colonies that declared independence...

 and Georgia

Georgia (U.S. state)

Georgia is a state located in the southeastern United States. It was established in 1732, the last of the original Thirteen Colonies. The state is named after King George II of Great Britain. Georgia was the fourth state to ratify the United States Constitution, on January 2, 1788...

. It goes through the cities of Columbia, South Carolina

Columbia, South Carolina

Columbia is the state capital and largest city in the U.S. state of South Carolina. The population was 129,272 according to the 2010 census. Columbia is the county seat of Richland County, but a portion of the city extends into neighboring Lexington County. The city is the center of a metropolitan...

 and Sumter, South Carolina

Sumter, South Carolina

-Demographics:, there were 59,180 people, 34,717 households, and 4,049 families living in the city. The population density was 4,469.5 people per square mile . There were 416,032 housing units at an average density of 603.0 per square mile...

. Beginning in Sumter, the route is overlapped by U.S. Route 76

U.S. Route 76

U.S. Route 76 is an east–west United States highway that runs for from Chattanooga, Tennessee to Wrightsville Beach, North Carolina.-Tennessee:...

 for approximately 40 miles (64.4 km) until they diverge in Columbia. Shortly before diverging, U.S. Route 378 is overlapped by U.S. Route 1

U.S. Route 1

U.S. Route 1 is a major north–south U.S. Highway that serves the East Coast of the United States. It runs 2,377 miles from Fort Kent, Maine at the Canadian border south to Key West, Florida. U.S. 1 generally parallels Interstate 95, though it is significantly farther west between...

 in Columbia until crossing over the Congaree River

Congaree River

The Congaree River is a short but wide river in South Carolina in the United States; It flows for only 47 miles . The river serves an important role as the final outlet channel for the entire Lower Saluda and Lower Broad watersheds, before merging with the Wateree River just north of Lake Marion to...

 into West Columbia, SC and diverging. The two routes briefly overlap again in Lexington, SC before diverging again. U.S. Route 378 provides an important link between Columbia and the cities of Sumter, Lexington, and Saluda.

Georgia

in Washington, GA

Washington, Georgia

Washington is a city in Wilkes County, Georgia, United States. The population was 4,295 at the 2000 census. The city is the county seat of Wilkes County...

 Western terminus near Metasville, GA in Lincolnton, GA

Lincolnton, Georgia

Lincolnton is a city in and the county seat of Lincoln County, Georgia, United States. The population was 1,595 at the 2000 census. It is the location for the historical site, Elijah Clark State Park, and contains numerous houses and historic districts listed on the National Register of Historic...

South Carolina

in McCormick, SC

McCormick, South Carolina

McCormick is a town in McCormick County, South Carolina, United States. The population was 1,489 at the 2000 census. It is the county seat of McCormick County.-Geography:McCormick is located at ....

 outside of Callison, SC outside of Owdoms, SC outside of Owdoms, SC in Saluda, SC

Saluda, South Carolina

Saluda is a town in Saluda County, South Carolina, along the Little Saluda River. The population was 3,066 at the 2000 census. It is the county seat of Saluda County.Saluda is part of the Columbia, South Carolina Metropolitan Statistical Area.-Geography:...

 east of Saluda, SC

Saluda, South Carolina

Saluda is a town in Saluda County, South Carolina, along the Little Saluda River. The population was 3,066 at the 2000 census. It is the county seat of Saluda County.Saluda is part of the Columbia, South Carolina Metropolitan Statistical Area.-Geography:...

 in Lexington, SC

Lexington, South Carolina

Lexington is a town in and the county seat of Lexington County, South Carolina, United States. The population was 17,870 at the 2010 census.-Geography:Lexington is located at ....

 near Lexington, SC

Lexington, South Carolina

Lexington is a town in and the county seat of Lexington County, South Carolina, United States. The population was 17,870 at the 2010 census.-Geography:Lexington is located at ....

 (EXIT 61) near W. Columbia, SC

West Columbia, South Carolina

West Columbia is a city in Lexington County, South Carolina, United States. The population was 13,064 at the 2000 census. It is part of the Columbia, South Carolina Metropolitan Statistical Area....

 in Columbia, SC

Columbia, South Carolina

Columbia is the state capital and largest city in the U.S. state of South Carolina. The population was 129,272 according to the 2010 census. Columbia is the county seat of Richland County, but a portion of the city extends into neighboring Lexington County. The city is the center of a metropolitan...

 in Columbia, SC

Columbia, South Carolina

Columbia is the state capital and largest city in the U.S. state of South Carolina. The population was 129,272 according to the 2010 census. Columbia is the county seat of Richland County, but a portion of the city extends into neighboring Lexington County. The city is the center of a metropolitan...

 in Columbia, SC

Columbia, South Carolina

Columbia is the state capital and largest city in the U.S. state of South Carolina. The population was 129,272 according to the 2010 census. Columbia is the county seat of Richland County, but a portion of the city extends into neighboring Lexington County. The city is the center of a metropolitan...

 near Columbia, SC

Columbia, South Carolina

Columbia is the state capital and largest city in the U.S. state of South Carolina. The population was 129,272 according to the 2010 census. Columbia is the county seat of Richland County, but a portion of the city extends into neighboring Lexington County. The city is the center of a metropolitan...

 in Lykes, SC in Horrell Hill, SC

Horrell Hill, South Carolina

Horrel Hill is an unincorporated community in Lower Richland County, South Carolina, South Carolina. Situated south of Fort Jackson and northwest of McEntire Joint National Guard Base, it is centered at about the intersection of Garner's Ferry Road and Harmon Road/Horrel Hill Road...

 near Eastover, SC

Eastover, South Carolina

Eastover is a town in Richland County, South Carolina, United States. The population was 830 at the 2000 census. It is part of the Columbia, South Carolina Metropolitan Statistical Area.-Geography:Eastover is located at ....

 near Eastover, SC

Eastover, South Carolina

Eastover is a town in Richland County, South Carolina, United States. The population was 830 at the 2000 census. It is part of the Columbia, South Carolina Metropolitan Statistical Area.-Geography:Eastover is located at ....

 near Eastover, SC

Eastover, South Carolina

Eastover is a town in Richland County, South Carolina, United States. The population was 830 at the 2000 census. It is part of the Columbia, South Carolina Metropolitan Statistical Area.-Geography:Eastover is located at ....

 in Stateburg, SC

Stateburg, South Carolina

Stateburg is a census-designated place in the High Hills of Santee in Sumter County, South Carolina, United States. The population was 1,264 at the 2000 census. It is included in the Sumter, South Carolina Metropolitan Statistical Area...

 near Stateburg, SC

Stateburg, South Carolina

Stateburg is a census-designated place in the High Hills of Santee in Sumter County, South Carolina, United States. The population was 1,264 at the 2000 census. It is included in the Sumter, South Carolina Metropolitan Statistical Area...

 in Sumter, SC

Sumter, South Carolina

-Demographics:, there were 59,180 people, 34,717 households, and 4,049 families living in the city. The population density was 4,469.5 people per square mile . There were 416,032 housing units at an average density of 603.0 per square mile...

 in Sumter, SC

Sumter, South Carolina

-Demographics:, there were 59,180 people, 34,717 households, and 4,049 families living in the city. The population density was 4,469.5 people per square mile . There were 416,032 housing units at an average density of 603.0 per square mile...

 in Sumter, SC

Sumter, South Carolina

-Demographics:, there were 59,180 people, 34,717 households, and 4,049 families living in the city. The population density was 4,469.5 people per square mile . There were 416,032 housing units at an average density of 603.0 per square mile...

 near Sumter, SC

Sumter, South Carolina

-Demographics:, there were 59,180 people, 34,717 households, and 4,049 families living in the city. The population density was 4,469.5 people per square mile . There were 416,032 housing units at an average density of 603.0 per square mile...

 in Turbeville, SC

Turbeville, South Carolina

Turbeville is a town in Clarendon County, South Carolina, United States. The population was 766 at the 2010 census.-Geography:Turbeville is located at...

 in Lake City, SC

Lake City, South Carolina

Lake City is a city in Florence County, South Carolina, United States. The population was 6,478 at the 2000 census...

 between Kingsburg, SC and Gresham, SC (Short multiplexes) near Brittons Neck, SC

Brittons Neck, South Carolina

Brittons Neck is an unincorporated community in Marion County, South Carolina, United States. Brittons Neck is located in the southern part of Marion County on Co. Route 908 south of Centenary and north of U.S. Route 378. Brittons Neck Elementary School is located near the community.-External links:*...

 in Conway, SC

Conway, South Carolina

Conway is a city in Horry County, South Carolina, United States. The population was 16,317 at the 2010 census. It is the county seat of Horry County and is part of the Myrtle Beach metropolitan area. It is the home of Coastal Carolina University....

Eastern terminus