19-Norandrosterone
Encyclopedia
19-Norandrosterone is a nandrolone
and 19-norandrostenedione
metabolite
. It is created as a byproduct of nandrolone via the 5-alpha reductase
enzyme and is on the list of substances prohibited by the World Anti-Doping Agency
since it is a detectable metabolite of nandrolone which is an anabolic steroid. Consumption of androstendione products contaminated with traces of 19-norandrostenedione
also results in testing positive for nandrolone. 19-Norandrosterone has very little if any anabolic activity on its own, but may be used as a prohormone to the weak anabolic steroid 19-nordehydrotestosterone that has only about 70% of the potency of testosterone in humans.
Traces of 19-norandrosterone are naturally present in human urine
. An experiment conducted on athletes showed that after a prolonged intense effort, the 19-norandrosterone concentration can be increased by a factor varying between 2 and 4, but another study failed to replicate the result. Concentration also increases in the urine of female athletes during menstruation
. The consumption of edible parts of a non-castrated pig, containing 19-nortestosterone, has been shown to results in the excretion of 19-norandrosterone in the following hours, so athletes should prudently avoid meals composed of pig offal
in the hours preceding doping tests. Consmption of boar meat, liver, kidneys and heart also increased 19-norandrosterone output.
19-Norandrosterone is also the basic skeleton structure for a family of C18 steroidal compounds called "dehydronorandrosterones".
Nandrolone
Nandrolone is an anabolic steroid that may be present naturally in the human body, albeit in minute quantities of less than 0.4 ng/ml. Nandrolone is most commonly sold commercially as its decanoate ester and less commonly as a phenylpropionate ester...
and 19-norandrostenedione
19-Norandrostenedione
19-Norandrostenedione is a precursor of the anabolic steroid nandrolone. Until 2005 19-Norandrostenedione was available without prescription in United States, where it was marketed as a prohormone, but it is now classified as a Schedule III drug...
metabolite
Metabolite
Metabolites are the intermediates and products of metabolism. The term metabolite is usually restricted to small molecules. A primary metabolite is directly involved in normal growth, development, and reproduction. Alcohol is an example of a primary metabolite produced in large-scale by industrial...
. It is created as a byproduct of nandrolone via the 5-alpha reductase
5-alpha reductase
5α-reductases, also known as 3-oxo-5α-steroid 4-dehydrogenases, are enzymes involved in steroid metabolism. They participate in 3 metabolic pathways: bile acid biosynthesis, androgen and estrogen metabolism, and prostate cancer....
enzyme and is on the list of substances prohibited by the World Anti-Doping Agency
World Anti-Doping Agency
The World Anti-Doping Agency , , is an independent foundation created through a collective initiative led by the International Olympic Committee . It was set up on November 10, 1999 in Lausanne, Switzerland, as a result of what was called the "Declaration of Lausanne", to promote, coordinate and...
since it is a detectable metabolite of nandrolone which is an anabolic steroid. Consumption of androstendione products contaminated with traces of 19-norandrostenedione
19-Norandrostenedione
19-Norandrostenedione is a precursor of the anabolic steroid nandrolone. Until 2005 19-Norandrostenedione was available without prescription in United States, where it was marketed as a prohormone, but it is now classified as a Schedule III drug...
also results in testing positive for nandrolone. 19-Norandrosterone has very little if any anabolic activity on its own, but may be used as a prohormone to the weak anabolic steroid 19-nordehydrotestosterone that has only about 70% of the potency of testosterone in humans.
Traces of 19-norandrosterone are naturally present in human urine
Urine
Urine is a typically sterile liquid by-product of the body that is secreted by the kidneys through a process called urination and excreted through the urethra. Cellular metabolism generates numerous by-products, many rich in nitrogen, that require elimination from the bloodstream...
. An experiment conducted on athletes showed that after a prolonged intense effort, the 19-norandrosterone concentration can be increased by a factor varying between 2 and 4, but another study failed to replicate the result. Concentration also increases in the urine of female athletes during menstruation
Menstruation
Menstruation is the shedding of the uterine lining . It occurs on a regular basis in sexually reproductive-age females of certain mammal species. This article focuses on human menstruation.-Overview:...
. The consumption of edible parts of a non-castrated pig, containing 19-nortestosterone, has been shown to results in the excretion of 19-norandrosterone in the following hours, so athletes should prudently avoid meals composed of pig offal
Offal
Offal , also called, especially in the United States, variety meats or organ meats, refers to the internal organs and entrails of a butchered animal. The word does not refer to a particular list of edible organs, which varies by culture and region, but includes most internal organs other than...
in the hours preceding doping tests. Consmption of boar meat, liver, kidneys and heart also increased 19-norandrosterone output.
19-Norandrosterone is also the basic skeleton structure for a family of C18 steroidal compounds called "dehydronorandrosterones".