Offseason

• November 22, 1999: George Williams was signed as a Free Agent with the San Diego Padres.
• December 22, 1999: Bret Boone
  Bret Boone
  Bret Robert Boone is a former Major League Baseball second baseman.-Personal life:Boone was born in El Cajon, California to Susan G. Roel and Bob Boone. He is a graduate of El Dorado High School and the University of Southern California. He is the grandson of former major leaguer Ray Boone and...
  
   was traded by the Atlanta Braves with Ryan Klesko and Jason Shiell to the San Diego Padres for Wally Joyner, Reggie Sanders, and Quilvio Veras.
• February 23, 2000: Al Martin was traded by the Pittsburgh Pirates with cash to the San Diego Padres for John Vander Wal, Geraldo Padua (minors), and James Sak (minors).

Opening Day starters

• Bret Boone
  Bret Boone
  Bret Robert Boone is a former Major League Baseball second baseman.-Personal life:Boone was born in El Cajon, California to Susan G. Roel and Bob Boone. He is a graduate of El Dorado High School and the University of Southern California. He is the grandson of former major leaguer Ray Boone and...
  
  
• Wiki Gonzalez
• Tony Gwynn
  Tony Gwynn
  Anthony Keith "Tony" Gwynn, Sr. , nicknamed Mr. Padre and Captain Video, is a former Major League Baseball right fielder. He is statistically one of the best and most consistent hitters in baseball history. He played his entire 20-year baseball career for the San Diego Padres...
  
  
• Damian Jackson
• Ryan Klesko
  Ryan Klesko
  Ryan Anthony Klesko , is a former Major League Baseball first baseman and corner outfielder, who played for the Atlanta Braves, San Diego Padres, and the San Francisco Giants...
  
  
• Al Martin
• Phil Nevin
  Phil Nevin
  Phillip Joseph Nevin is a retired American professional baseball player who spent twelve seasons in Major League Baseball with the Houston Astros , Detroit Tigers , Anaheim Angels , San Diego Padres , Texas Rangers , Chicago Cubs and Minnesota Twins...
  
  
• Eric Owens
• Woody Williams
  Woody Williams
  Gregory Scott "Woody" Williams is a former right-handed Major League Baseball starting pitcher. He made his major league debut for the Toronto Blue Jays on May 14, 1993.-Baseball career:...
  
  

Notable transactions

• June 5, 2000: Xavier Nady was drafted by the San Diego Padres in the 2nd round of the 2000 Major League Baseball Draft
  2000 Major League Baseball Draft
  -First Round Selections:-Compensation picks:- Background :The Florida Marlins made Adrian Gonzalez of Eastlake High School in Chula Vista, CA the first overall selection in the 2000 First-Year Player Draft...
  
  . Player signed September 17, 2000.
• July 31, 2000: Heathcliff Slocumb
  Heathcliff Slocumb
  Heath "Heathcliff" Slocumb is a former Major League Baseball relief pitcher. He batted and threw right-handed....
  
   was traded by the St. Louis Cardinals with Ben Johnson to the San Diego Padres for Carlos Hernandez and Nate Tebbs (minors).
• July 31, 2000: John Mabry
  John Mabry
  John Steven Mabry is a former Major League Baseball player. He had 898 career hits in 3409 at bats , with 96 home runs and 446 RBI...
  
   was traded by the Seattle Mariners with Tom Davey to the San Diego Padres for Al Martin
  Al Martin
  Albert Lee Martin is a former professional baseball left fielder. He played twelve seasons in Major League Baseball, mostly for the Pittsburgh Pirates. He also played one season in the Korea Baseball Organization.- Early life :Martin graduated from John A...
  
  .

Roster

Starters by position

Other batters

Starting pitchers

Other pitchers

Relief pitchers

Farm system