March

• 4 March – Ian Syster
  Ian Syster
  Ian Syster was a South African long-distance runner who specialized in the marathon.He was born in Prince Albert. He finished fourteenth at the 2001 World Championships and seventh at the 2003 World Championships. He also competed at the 2004 Olympic Games, but did not finish the race...
  
   wins his first national title in the men's marathon, clocking 2:13:30 in Durban
  Durban
  Durban is the largest city in the South African province of KwaZulu-Natal and the third largest city in South Africa. It forms part of the eThekwini metropolitan municipality. Durban is famous for being the busiest port in South Africa. It is also seen as one of the major centres of tourism...
  
  .
• 18 March – The Department of Health declines the offer of a large donation of HIV test kits made by Guardian Scientific Africa Incorporated

April

• 5 April – George Bizos
  George Bizos
  George Bizos is a distinguished human rights advocate who campaigned against apartheid in South Africa, most notably during the Rivonia Trial.-Early life:...
  
   is awarded the 2001 International Trial Lawyer Prize of the Year by the International Academy of Trial Lawyers
• 11 April – Pfizer Inc., a pharmaceutical company, agrees to supply AIDS patients attending public hospitals with an unlimited two-year supply of Fluconazole
  Fluconazole
  Fluconazole is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections. In a bulk powder form, it appears as a white crystalline powder, and it is very slightly soluble in water and soluble in alcohol. It is commonly marketed under the trade...
  
  
• 30 April – South Africa and India sign a declaration of intent on co-operation in health and medicine

June

• 11 June – The Maloti-Drakensberg Transfrontier Conservation Area
  Maloti-Drakensberg Transfrontier Conservation Area
  Maloti-Drakensberg Transfrontier Conservation Area was established on 11 June 2001 by linking the Sehlabathebe National Park in the Kingdom of Lesotho and the uKhahlamba Drakensberg Park in KwaZulu-Natal, South Africa. The total park will be: 16.226 Km² large. This 300 km long Peace park covers...
  
   is signed into existence
• 12–15 June – President of South Africa
  President of South Africa
  The President of the Republic of South Africa is the head of state and head of government under South Africa's Constitution. From 1961 to 1994, the head of state was called the State President....
  
  , Thabo Mbeki
  Thabo Mbeki
  Thabo Mvuyelwa Mbeki is a South African politician who served two terms as the second post-apartheid President of South Africa from 14 June 1999 to 24 September 2008. He is also the brother of Moeletsi Mbeki...
  
  , visits the United Kingdom on a state visit.

October

• The name of Gaza-Kruger-Gonarezhou Transfrontier Park is changed to the Great Limpopo Transfrontier Park
  Great Limpopo Transfrontier Park
  Great Limpopo Transfrontier Park is a 35,000 km² peace park that is in the process of being formed. It will link the Limpopo National Park in Mozambique, Kruger National Park in South Africa, Gonarezhou National Park, Manjinji Pan Sanctuary and Malipati Safari Area in Zimbabwe, as well as the...
  
  
• 4 October – The first 40 (including 3 breeding herds) of a planned 1000 elephants is translocated from the over-populated Kruger National Park
  Kruger National Park
  Kruger National Park is one of the largest game reserves in Africa. It covers and extends from north to south and from east to west.To the west and south of the Kruger National Park are the two South African provinces of Limpopo and Mpumalanga. In the north is Zimbabwe, and to the east is...
  
   to the war-ravaged Limpopo National Park
  Limpopo National Park
  The Limpopo National Park was born when the status of Coutada 16 Wildlife Utilisation Area in Gaza Province, Mozambique, was changed from a hunting concession to a protected area....
  
  
• 9 October – The second South African National Census
  South African National Census of 2001
  The South African National Census of 2001 is the most recent national census of South Africa.The census was undertaken by Statistics South Africa and undertook to enumerate every person present in South Africa on the census night, 9–10 October 2001. The enumeration primarily took place from 10 to...
  
   is held

December

• 4 December – Marike de Klerk
  Marike de Klerk
  Marike de Klerk was the First Lady of South Africa, as the wife of President Frederik Willem de Klerk, from 1989 to 1994, as well as a politician of the governing National Party in her own right.Mr FW de Klerk and Marike de Klerk divorced in 1998...
  
  , ex-wife of Frederik Willem de Klerk
  Frederik Willem de Klerk
  Frederik Willem de Klerk , often known as F. W. de Klerk, is the former seventh and last State President of apartheid-era South Africa, serving from September 1989 to May 1994...
  
   is murdered in her flat in Cape Town
  Cape Town
  Cape Town is the second-most populous city in South Africa, and the provincial capital and primate city of the Western Cape. As the seat of the National Parliament, it is also the legislative capital of the country. It forms part of the City of Cape Town metropolitan municipality...
  
  .

Unknown date

• The New National Party leaves the Democratic Alliance