The play-off first legs were played on 8 October 2010, while the second legs were played on 12 October 2010. Winners of play-off round and host nation Denmark will participate in the championship next year.

Matches

The draw took place on 10 September 2010 in Herning, Denmark. 14 teams were drawn into 7 two-legged ties. The matches between Iceland and Scotland were moved back a day to avoid a fixture clash with full internationals.

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First leg

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Second leg

Switzerland won 5–2 on aggregate and qualified for the 2011 UEFA European Under-21 Championship
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Iceland won 4–2 on aggregate and qualified for the 2011 UEFA European Under-21 Championship
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England won 2–1 on aggregate and qualified for the 2011 UEFA European Under-21 Championship
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Spain won 5–1 on aggregate and qualified for the 2011 UEFA European Under-21 Championship
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Belarus won 3–2 on aggregate and qualified for the 2011 UEFA European Under-21 Championship
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Czech Republic won 5–0 on aggregate and qualified for the 2011 UEFA European Under-21 Championship
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3–3 on aggregate, Ukraine won on away goals and qualified for the 2011 UEFA European Under-21 Championship