3F8
Encyclopedia
3F8 is a murine IgG3 monoclonal antibody which binds to GD2
.
It has been used in the detection and treatment of neuroblastoma
. For imaging neuroblastoma, it is labelled with one of the radioisotopes iodine-124 and iodine-131
.
GD2
GD2 is a disialoganglioside expressed on tumors of neuroectodermal origin, including human neuroblastoma and melanoma, with highly restricted expression on normal tissues, principally to the cerebellum and peripheral nerves in humans....
.
It has been used in the detection and treatment of neuroblastoma
Neuroblastoma
Neuroblastoma is the most common extracranial solid cancer in childhood and the most common cancer in infancy, with an annual incidence of about 650 cases per year in the US , and 100 cases per year in the UK . Close to 50 percent of neuroblastoma cases occur in children younger than two years old...
. For imaging neuroblastoma, it is labelled with one of the radioisotopes iodine-124 and iodine-131
Iodine-131
Iodine-131 , also called radioiodine , is an important radioisotope of iodine. It has a radioactive decay half-life of about eight days. Its uses are mostly medical and pharmaceutical...
.