4-aminobutyrate aminotransferase
Encyclopedia
4-aminobutyrate aminotransferase (or GABA transaminase) is an enzyme which catalyzes the conversion of 4-aminobutanoic acid (GABA) and 2-oxoglutarate into succinic semialdehyde
and glutamate.
Succinic semialdehyde
Succinic semialdehyde is a GABA analogue.-See also:* Succinic semialdehyde dehydrogenase deficiency* 4-aminobutyrate aminotransferase...
and glutamate.
Inhibitors
- Aminooxyacetic acidAminooxyacetic acidAminooxyacetic acid, often abbreviated AOA or AOAA, is a compound that inhibits 4-aminobutyrate aminotransferase activity in vitro and in vivo, leading to less gamma-aminobutyric acid being broken down. Subsequently, the level of GABA is increased in tissues...
- GabaculineGabaculineGabaculine is a naturally occurring neurotoxin first isolated from the bacteria Streptomyces toyacaensis, which acts as a potent and irreversible GABA transaminase inhibitor, and also a GABA reuptake inhibitor....
- PhenelzinePhenelzinePhenelzine is a non-selective and irreversible monoamine oxidase inhibitor of the hydrazine class which is used as an antidepressant and anxiolytic...
- PhenylethylidenehydrazinePhenylethylidenehydrazinePhenylethylidenehydrazine is an inhibitor of the enzyme GABA transaminase . It is a metabolite of the antidepressant phenelzine and is responsible for its elevation of GABA concentrations. PEH likely plays a significant role in phenelzine's high efficacy in treating anxiety disorders....
(PEH) - Valproic acidValproic acidValproic acid is a chemical compound that has found clinical use as an anticonvulsant and mood-stabilizing drug, primarily in the treatment of epilepsy, bipolar disorder, and, less commonly, major depression. It is also used to treat migraine headaches and schizophrenia...
- VigabatrinVigabatrinVigabatrin is an antiepileptic drug that inhibits the catabolism of gamma-aminobutyric acid by irreversibly inhibiting GABA transaminase. It is an analog of GABA, but it is not a receptor agonist...