5-Carboxamidotryptamine (5-CT) is a tryptamine

Tryptamine

Tryptamine is a monoamine alkaloid found in plants, fungi, and animals. It is based around the indole ring structure, and is chemically related to the amino acid tryptophan, from which its name is derived...

 derivative closely related to the neurotransmitter

Neurotransmitter

Neurotransmitters are endogenous chemicals that transmit signals from a neuron to a target cell across a synapse. Neurotransmitters are packaged into synaptic vesicles clustered beneath the membrane on the presynaptic side of a synapse, and are released into the synaptic cleft, where they bind to...

 serotonin

Serotonin

Serotonin or 5-hydroxytryptamine is a monoamine neurotransmitter. Biochemically derived from tryptophan, serotonin is primarily found in the gastrointestinal tract, platelets, and in the central nervous system of animals including humans...

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5-CT acts as a non-selective

Functional Selectivity

Functional selectivity is the ligand-dependent selectivity for certain signal transduction pathways in one and the same receptor. This can be present when a receptor has several possible signal transduction pathways...

, high-affinity full agonist at the 5-HT_1A, 5-HT_1B, 5-HT_1D, 5-HT_5A, and 5-HT₇ receptors, as well as at the 5-HT₂, 5-HT₃, 5-HT₆ receptors with lower affinity. It has negligible affinity for the 5-HT_1E and 5-HT_1F receptors. 5-CT binds strongest to the 5-HT_1A receptor and it was once thought to be selective for this site.

See also

• 2-Methyl-5-hydroxytryptamine
  2-Methyl-5-hydroxytryptamine
  2-Methyl-5-hydroxytryptamine is a tryptamine derivative closely related to the neurotransmitter serotonin which acts as a moderately selective full agonist at the 5-HT3 receptor.- See also :...
  
  
• 5-Benzyloxytryptamine
  5-Benzyloxytryptamine
  5-Benzyloxytryptamine , is a tryptamine derivative which acts as an agonist at the 5-HT1D, 5-HT2 and 5-HT6 serotonin receptors.- See also :* 5-Carboxamidotryptamine* 5-Methoxytryptamine* BW-723C86* Sumatriptan- References :...
  
  
• 5-Methoxytryptamine
  5-Methoxytryptamine
  5-Methoxytryptamine , also known as mexamine, is a tryptamine derivative closely related to the neurotransmitters serotonin and melatonin. 5-MT has been shown to occur naturally in the body in low levels. It is biosynthesized via the deacetylation of melatonin in the pineal gland.5-MT acts as a...
  
  
• α-Methyl-5-hydroxytryptamine
• Sumatriptan
  Sumatriptan
  Sumatriptan is a triptan sulfa drug containing a sulfonamide group. It is used for the treatment of migraine headaches. Sumatriptan is produced and marketed by various drug manufacturers with many different trade names such as Sumatriptan, Imitrex, Imigran, Imigran recovery.-Approval and...