6-Phosphogluconate
Encyclopedia
6-Phosphogluconic acid (6-phosphogluconate) is an intermediate in the pentose phosphate pathway
and the Entner–Doudoroff pathway.
It is formed by 6-phosphogluconolactonase
, and acted upon by phosphogluconate dehydrogenase
to produce ribulose 5-phosphate
. It may also be acted upon by 6-phosphogluconate dehydratase
to produce 2-keto,3-deoxy-6-phosphogluconate.
Pentose phosphate pathway
The pentose phosphate pathway is a process that generates NADPH and pentoses . There are two distinct phases in the pathway. The first is the oxidative phase, in which NADPH is generated, and the second is the non-oxidative synthesis of 5-carbon sugars...
and the Entner–Doudoroff pathway.
It is formed by 6-phosphogluconolactonase
6-phosphogluconolactonase
6-Phosphogluconolactonase is an enzyme in the pentose phosphate pathway. It converts 6-phosphogluconolactone to 6-phosphogluconate....
, and acted upon by phosphogluconate dehydrogenase
Phosphogluconate dehydrogenase
Phosphogluconate dehydrogenase is an enzyme in the pentose phosphate pathway. It forms ribulose 5-phosphate from 6-phosphogluconate.It is an oxidative carboxylase that catalyses the decarboxylating reduction of 6-phosphogluconate into ribulose 5-phosphate in the presence of NADP. This reaction is a...
to produce ribulose 5-phosphate
Ribulose 5-phosphate
Ribulose 5-phosphate is one of the end-products of the pentose phosphate pathway. It is also an intermediate in the Calvin cycle.It is formed by phosphogluconate dehydrogenase, and it can be acted upon by phosphopentose isomerase and phosphopentose epimerase....
. It may also be acted upon by 6-phosphogluconate dehydratase
Phosphogluconate dehydratase
In enzymology, a phosphogluconate dehydratase is an enzyme that catalyzes the chemical reactionHence, this enzyme has one substrate, 6-phospho-D-gluconate, and two products, 2-dehydro-3-deoxy-6-phospho-D-gluconate and H2O....
to produce 2-keto,3-deoxy-6-phosphogluconate.