ABT-239
Encyclopedia
ABT-239 is an H3-receptor inverse agonist
developed by Abbott
. It has stimulant
and nootropic
effects, and has been investigated as a treatment for ADHD, Alzheimer's disease
, and schizophrenia
. ABT-239 is more active at the human H3 receptor than comparable agents such as thioperamide
, ciproxifan
, and cipralisant
. It was ultimately dropped from human trials after showing the dangerous cardiac side effect of QT prolongation, but is still widely used in animal research into H3 antagonists / inverse agonists.
Inverse agonist
In the field of pharmacology, an inverse agonist is an agent that binds to the same receptor as an agonist but induces a pharmacological response opposite to that agonist....
developed by Abbott
Abbott Laboratories
Abbott Laboratories is an American-based global, diversified pharmaceuticals and health care products company. It has 90,000 employees and operates in over 130 countries. The company headquarters are in Abbott Park, North Chicago, Illinois. The company was founded by Chicago physician, Dr....
. It has stimulant
Stimulant
Stimulants are psychoactive drugs which induce temporary improvements in either mental or physical function or both. Examples of these kinds of effects may include enhanced alertness, wakefulness, and locomotion, among others...
and nootropic
Nootropic
Nootropics , also referred to as smart drugs, brain steroids, memory enhancers, cognitive enhancers, and intelligence enhancers, are drugs, supplements, nutraceuticals, and functional foods that improve mental functions such as cognition, memory, intelligence, motivation, attention, and concentration...
effects, and has been investigated as a treatment for ADHD, Alzheimer's disease
Alzheimer's disease
Alzheimer's disease also known in medical literature as Alzheimer disease is the most common form of dementia. There is no cure for the disease, which worsens as it progresses, and eventually leads to death...
, and schizophrenia
Schizophrenia
Schizophrenia is a mental disorder characterized by a disintegration of thought processes and of emotional responsiveness. It most commonly manifests itself as auditory hallucinations, paranoid or bizarre delusions, or disorganized speech and thinking, and it is accompanied by significant social...
. ABT-239 is more active at the human H3 receptor than comparable agents such as thioperamide
Thioperamide
Thioperamide is a potent and selective histamine H3 antagonist that is capable of crossing the blood-brain barrier....
, ciproxifan
Ciproxifan
Ciproxifan is an extremely potent histamine H3 inverse agonist/antagonist.The histamine H3 receptor is an inhibitory autoreceptor located on histaminergic nerve terminals, and is believed to be involved in modulating the release of histamine in the brain...
, and cipralisant
Cipralisant
Cipralisant is an extremely potent Histamine H3 receptor ligand originally developed by Gliatech...
. It was ultimately dropped from human trials after showing the dangerous cardiac side effect of QT prolongation, but is still widely used in animal research into H3 antagonists / inverse agonists.