ANAPC1
Encyclopedia
Anaphase-promoting complex subunit 1 is an enzyme
that in humans is encoded by the ANAPC1 gene
.
ANAPC1 is one of at least ten subunits of the anaphase-promoting complex (APC), which functions at the metaphase-to-anaphase transition of the cell cycle and is regulated by spindle checkpoint proteins. The APC is an E3 ubiquitin ligase that targets cell cycle regulatory proteins for degradation by the proteasome, thereby allowing progression through the cell cycle.[supplied by OMIM]
with ANAPC5
, ANAPC4
, ANAPC2
, CDC27
and ANAPC7
.
Enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...
that in humans is encoded by the ANAPC1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
ANAPC1 is one of at least ten subunits of the anaphase-promoting complex (APC), which functions at the metaphase-to-anaphase transition of the cell cycle and is regulated by spindle checkpoint proteins. The APC is an E3 ubiquitin ligase that targets cell cycle regulatory proteins for degradation by the proteasome, thereby allowing progression through the cell cycle.[supplied by OMIM]
Interactions
ANAPC1 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with ANAPC5
ANAPC5
Anaphase-promoting complex subunit 5 is an enzyme that in humans is encoded by the ANAPC5 gene.-Interactions:ANAPC5 has been shown to interact with ANAPC1, ANAPC4, CDC27 and PABPC1.-Further reading:...
, ANAPC4
ANAPC4
Anaphase-promoting complex subunit 4 is an enzyme that in humans is encoded by the ANAPC4 gene.- Interactions :ANAPC4 has been shown to interact with ANAPC1, ANAPC5, CDC27 and ANAPC7.- Further reading :...
, ANAPC2
ANAPC2
Anaphase-promoting complex subunit 2 is an enzyme that in humans is encoded by the ANAPC2 gene.A large protein complex, termed the anaphase-promoting complex , or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase...
, CDC27
CDC27
Cell division cycle protein 27 homolog is a protein that in humans is encoded by the CDC27 gene.-Interactions:CDC27 has been shown to interact with ANAPC1, ANAPC4, ANAPC5, ANAPC11, FZR1, CDC20, CDH1, CDC23, PIN1, CDC16, ANAPC7, MAD2L1 and ANAPC10....
and ANAPC7
ANAPC7
Anaphase-promoting complex subunit 7 is an enzyme that in humans is encoded by the ANAPC7 gene.-Interactions:ANAPC7 has been shown to interact with ANAPC1, ANAPC4, CDC27 and CDC20.-Further reading:...
.