ANGPTL4
Encyclopedia
Angiopoietin-related protein 4 is a protein
that in humans is encoded by the ANGPTL4 gene
.
ANGPTL4 inhibits lipoprotein lipase
, LPL, by breaking the dimer molecule. ANGPTL3
and ANGPTL4 have been unambiguously established as potent inhibitors of blood plasma
Triglyceride
(TG) clearance, causing elevation of plasma TG levels.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the ANGPTL4 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
ANGPTL4 inhibits lipoprotein lipase
Lipoprotein lipase
Lipoprotein lipase is a member of the lipase gene family, which includes pancreatic lipase, hepatic lipase, and endothelial lipase. It is a water soluble enzyme that hydrolyzes triglycerides in lipoproteins, such as those found in chylomicrons and very low-density lipoproteins , into two free...
, LPL, by breaking the dimer molecule. ANGPTL3
ANGPTL3
Angiopoietin-like 3, also known as ANGPTL3, is a protein which in humans is encoded by the ANGPTL3 gene.- Function :The protein encoded by this gene is a member of the angiopoietin-like family of secreted factors...
and ANGPTL4 have been unambiguously established as potent inhibitors of blood plasma
Blood plasma
Blood plasma is the straw-colored liquid component of blood in which the blood cells in whole blood are normally suspended. It makes up about 55% of the total blood volume. It is the intravascular fluid part of extracellular fluid...
Triglyceride
Triglyceride
A triglyceride is an ester derived from glycerol and three fatty acids. There are many triglycerides, depending on the oil source, some are highly unsaturated, some less so....
(TG) clearance, causing elevation of plasma TG levels.