AP4E1
Encyclopedia
AP-4 complex subunit epsilon-1 is a protein
that in humans is encoded by the AP4E1 gene
.
) and epsilon-4 (AP4E1; this gene), a medium chain, mu-4 (AP4M1
), and a small chain, sigma-4 (AP4S1
).
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the AP4E1 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Function
The heterotetrameric adaptor protein (AP) complexes sort integral membrane proteins at various stages of the endocytic and secretory pathways. AP4 is composed of 2 large chains, beta-4 (AP4B1AP4B1
AP-4 complex subunit beta-1 is a protein that in humans is encoded by the AP4B1 gene.-Clinical relevance:It is currently hypothesized that AP4-complex-mediated trafficking plays a crucial role in brain development and functioning.-Further reading:...
) and epsilon-4 (AP4E1; this gene), a medium chain, mu-4 (AP4M1
AP4M1
AP-4 complex subunit mu-1 is a protein that in humans is encoded by the AP4M1 gene.-Clinical relevance:It is currently hypothesized that AP4-complex-mediated trafficking plays a crucial role in brain development and functioning.-Further reading:...
), and a small chain, sigma-4 (AP4S1
AP4S1
AP-4 complex subunit sigma-1 is a protein that in humans is encoded by the AP4S1 gene.- Function :The heterotetrameric adaptor protein complexes sort integral membrane proteins at various stages of the endocytic and secretory pathways...
).