APOBEC
Encyclopedia
APOBEC is a family of evolutionary conserved proteins:

A mechanism of generating protein diversity is mRNA
Messenger RNA
Messenger RNA is a molecule of RNA encoding a chemical "blueprint" for a protein product. mRNA is transcribed from a DNA template, and carries coding information to the sites of protein synthesis: the ribosomes. Here, the nucleic acid polymer is translated into a polymer of amino acids: a protein...

 editing. Members of this family are C-to-U editing enzymes. The N-terminal domain of APOBEC like proteins is the catalytic domain, while the C-terminal domain is a pseudocatalyitc domain. More specifically, the catalytic domain is a zinc dependent cytidine deaminase domain and is essential for cytidine deamination. RNA editing by APOBEC-1 requires homodimerisation and this complex interacts with RNA binding proteins to from the editosome.

Family members

Human genes encoding members of the APOBEC protein family include:
  • APOBEC1
  • APOBEC2
  • APOBEC3A
    APOBEC3A
    Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A, also known as APOBEC3A, is a gene of the APOBEC3 family found in at least in humans.. It is a cytidine deaminase with antiviral effects...

  • APOBEC3C
  • APOBEC3D ("APOBEC3E" now refers to this)
  • APOBEC3F
  • APOBEC3G
    APOBEC3G
    APOBEC3G is a human enzyme encoded by the APOBEC3G gene that belongs to the APOBEC superfamily of proteins. This family of proteins has been suggested to play an important role in innate anti-viral immunity...

  • APOBEC3H
  • APOBEC4
The source of this article is wikipedia, the free encyclopedia.  The text of this article is licensed under the GFDL.
 
x
OK