AS03
Encyclopedia
AS03 is the trade name for a squalene
-based immunologic adjuvant
used in various vaccine products by GlaxoSmithKline
(GSK). It is used, for example, in GSK's A/H1N1 pandemic flu vaccine Pandemrix
.
A dose of AS03 adjuvant contains
Squalene
Squalene is a natural organic compound originally obtained for commercial purposes primarily from shark liver oil, though plant sources are used as well, including amaranth seed, rice bran, wheat germ, and olives. All plants and animals produce squalene, including humans...
-based immunologic adjuvant
Immunologic adjuvant
In immunology, an adjuvant is an agent that may stimulate the immune system and increase the response to a vaccine, without having any specific antigenic effect in itself. The word “adjuvant” comes from the Latin word adiuvare, meaning to help or aid...
used in various vaccine products by GlaxoSmithKline
GlaxoSmithKline
GlaxoSmithKline plc is a global pharmaceutical, biologics, vaccines and consumer healthcare company headquartered in London, United Kingdom...
(GSK). It is used, for example, in GSK's A/H1N1 pandemic flu vaccine Pandemrix
Pandemrix
Pandemrix is an influenza vaccine for influenza pandemics, such as the H1N1 2009 flu pandemic colloquially called the swine flu. The vaccine was developed by GlaxoSmithKline and patented in September 2006....
.
A dose of AS03 adjuvant contains
- 10.69 mg squaleneSqualeneSqualene is a natural organic compound originally obtained for commercial purposes primarily from shark liver oil, though plant sources are used as well, including amaranth seed, rice bran, wheat germ, and olives. All plants and animals produce squalene, including humans...
- 11.86 mg DL-α-tocopherol
- 4.86 mg polysorbate 80Polysorbate 80Polysorbate 80 is a nonionic surfactant and emulsifier derived from polyethoxylated sorbitan and oleic acid, and is often used in foods. Polysorbate 80 is a viscous, water-soluble yellow liquid...
See also
- 2009 flu pandemic2009 flu pandemicThe 2009 flu pandemic was an influenza pandemic, and the second of the two pandemics involving H1N1 influenza virus , albeit in a new version...
- MF59MF59MF59 is an immunologic adjuvant that uses squalene. It is Novartis' proprietary adjuvant that is added to influenza vaccines to help stimulate the human body's immune response through production of CD4 memory cells. MF59 is the first oil-in-water influenza vaccine adjuvant to be commercialized in...
– another squalene-based adjuvant by Novartis - AS04AS04AS04 is a trade name for combination of adjuvants used in various vaccine product by GlaxoSmithKline , in particular the Cervarix HPV vaccine. It consists of aluminum hydroxide and monophosphoryl lipid A . Furthermore it is the successor of AS03 which is a Squalene based adjuvant.-External links:***...
– another adjuvant by GSK