A04AA Serotonin

Serotonin

Serotonin or 5-hydroxytryptamine is a monoamine neurotransmitter. Biochemically derived from tryptophan, serotonin is primarily found in the gastrointestinal tract, platelets, and in the central nervous system of animals including humans...

 (5-HT₃) antagonists

Receptor antagonist

A receptor antagonist is a type of receptor ligand or drug that does not provoke a biological response itself upon binding to a receptor, but blocks or dampens agonist-mediated responses...

A04AA01 Ondansetron

Ondansetron

Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic , often following chemotherapy. Its effects are thought to be on both peripheral and central nerves...

A04AA02 Granisetron

Granisetron

Granisetron is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. Its main effect is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata. It does not have much effect...

A04AA03 Tropisetron

Tropisetron

Tropisetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic to treat nausea and vomiting following chemotherapy, although it has been used experimentally as an analgesic in cases of fibromyalgia. The drug is available in a 5 mg oral preparation or in 2 mg...

A04AA04 Dolasetron

Dolasetron

Dolasetron is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy. Its main effect is to reduce the activity of the vagus nerve, which is a nerve that activates the vomiting center in the medulla oblongata. It does not have much antiemetic effect when...

A04AA05 Palonosetron

Palonosetron

Palonosetron is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting...

A04AD Other antiemetics

A04AD01 Scopolamine

Scopolamine

Scopolamine, also known as levo-duboisine, and hyoscine, is a tropane alkaloid drug with muscarinic antagonist effects. It is among the secondary metabolites of plants from Solanaceae family of plants, such as henbane, jimson weed and Angel's Trumpets , and corkwood...

A04AD02 Cerium oxalate

Cerium oxalate

Cerium oxalate is the inorganic cerium salt of oxalic acid. It is a white crystalline solid with the chemical formula of Ce23. It may be formed by the reaction of oxalic acid and cerium oxide.Cerium oxalate is used as an antiemetic....

A04AD04 Chlorobutanol

Chlorobutanol

Chlorobutanol, or trichloro-2-methyl-2-propanol, is a chemical preservative, sedative hypnotic and weak local anaesthetic similar in nature to chloral hydrate. It has antibacterial and antifungal properties...

A04AD05 Metopimazine

Metopimazine

Metopimazine is a phenothiazine antiemetic.Jacob, R. M.; Robert, J. G.; 1959, ....

A04AD10 Dronabinol

A04AD11 Nabilone

Nabilone

Nabilone is a synthetic cannabinoid with therapeutic use as an antiemetic and as an adjunct analgesic for neuropathic pain. It is a synthetic cannabinoid, which mimics the main ingredient of cannabis...

A04AD12 Aprepitant

Aprepitant

Aprepitant is an antiemetic chemical compound that belongs to a class of drugs called substance P antagonists . It mediates its effect by blocking the neurokinin 1 receptor.Aprepitant is manufactured by Merck & Co...

A04AD13 Casopitant

Casopitant

Casopitant is an neurokinin 1 receptor antagonist undergoing research for the treatment of chemotherapy-induced nausea and vomiting . It is currently under development by GlaxoSmithKline ....

A04AD51 Scopolamine, combinations

A04AD54 Chlorobutanol, combinations

QA04AD90 Maropitant

Maropitant

Maropitant , used as maropitant citrate , is a neurokinin receptor antagonist, which was developed by Pfizer Animal Health specifically for the treatment of motion sickness and vomiting in dogs. It has not been approved by the FDA for use in any animal except dogs...