Achard–Thiers syndrome combines the features of Adrenogenital syndrome and Cushing syndrome

Cushing's syndrome

Cushing's syndrome is a hormone disorder caused by high levels of cortisol in the blood. This can be caused by taking glucocorticoid drugs, or by tumors that produce cortisol or adrenocorticotropic hormone or CRH...

. It is also known as diabetic-bearded woman syndrome (diabète des femmes à barbe).

The disease is named for Emile Achard

Emile Achard

Emile Achard, full name Emile Charles Achard was a French internist born in Paris. In 1893 he became médecin des hôpitaux, and later a professor of general pathology and therapeutics. In 1910 he was appointed professor of internal medicine at the University of Paris...

 and Joseph Thiers.

Clinical features

Achard–Thiers syndrome affects mostly postmenopausal women and comprises diabetes mellitus

Diabetes mellitus

Diabetes mellitus, often simply referred to as diabetes, is a group of metabolic diseases in which a person has high blood sugar, either because the body does not produce enough insulin, or because cells do not respond to the insulin that is produced...

, deep voice, hirsutism

Hirsutism

Hirsutism or frazonism is the excessive hairiness on women in those parts of the body where terminal hair does not normally occur or is minimal - for example, a beard or chest hair. It refers to a male pattern of body hair and it is therefore primarily of cosmetic and psychological concern...

 or hypertrichosis

Hypertrichosis

Hypertrichosis is an abnormal amount of hair growth on the body; extensive cases of hypertrichosis have informally been called werewolf syndrome. There are two distinct types of hypertrichosis: generalized hypertrichosis, which occurs over the entire body, and localized hypertrichosis, which is...

, clitoral hypertrophy and adrenal cortical hyperplasia or adenoma

Congenital adrenal hyperplasia

Congenital adrenal hyperplasia refers to any of several autosomal recessive diseases resulting from mutations of genes for enzymes mediating the biochemical steps of production of cortisol from cholesterol by the adrenal glands ....

. Patients often also have amenorrhoea

Amenorrhoea

Amenorrhoea , amenorrhea , or amenorrhœa, is the absence of a menstrual period in a woman of reproductive age. Physiological states of amenorrhoea are seen during pregnancy and lactation , the latter also forming the basis of a form of contraception known as the lactational amenorrhoea method...

, hypertension

Hypertension

Hypertension or high blood pressure is a cardiac chronic medical condition in which the systemic arterial blood pressure is elevated. What that means is that the heart is having to work harder than it should to pump the blood around the body. Blood pressure involves two measurements, systolic and...

 and osteoporosis

Osteoporosis

Osteoporosis is a disease of bones that leads to an increased risk of fracture. In osteoporosis the bone mineral density is reduced, bone microarchitecture is deteriorating, and the amount and variety of proteins in bone is altered...

.