Allopumiliotoxin 267A is a toxin found in the skin of several poison frogs of the family Dendrobates

Dendrobates

Dendrobates is a genus of poison dart frogs native to South America. It once contained all poison dart frogs; until recently, frogs such as Dendrobates pumilio and Dendrobates terribilis were scientifically valid names...

. It is a member of the class of compounds known as allopumiliotoxin

Allopumiliotoxin

Allopumiliotoxins are a structural division in the pumiliotoxin-A class of alkaloids. The compounds of the pumiliotoxin-A class are primarily found in the skins of frogs, toads, and other amphibians and are used as a chemical defense mechanism to ward off predators, microorganisms, and ectoparasites...

s. The frogs produce the toxin by modifying the original version, pumiliotoxin 251D

Pumiliotoxin 251D

Pumiliotoxin 251D is one of the toxins found in the skin of poison frogs from the Dendrobates, Epipedobates, Minyobates and Phyllobates and toads from the Melanophryniscus families. It is not manufactured by the amphibians, but absorbed through their insect-rich diet...

. It has been tested on mice and found to be five times more potent than the former version. It has been produced synthetically through a variety of different routes.