Alpha-2C adrenergic receptor
Encyclopedia
The alpha-2C adrenergic receptor (α2C adrenoceptor), also known as ADRA2C, is an alpha-2 adrenergic receptor
, and also denotes the human gene
encoding it.
Alpha-2 adrenergic receptor
The alpha-2 adrenergic receptor is a G protein-coupled receptor associated with the Gi heterotrimeric G-protein. It consists of three highly homologous subtypes, including α2A-, α2B-, and α2C-adrenergic. Some species other than humans express a fourth α2D-adrenergic receptor as well...
, and also denotes the human gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
encoding it.
Agonists
- (R)-3-Nitrobiphenyline(R)-3-Nitrobiphenyline-3-Nitrobiphenyline is a drug which acts as an α2-adrenergic agonist, selective for the α2C subtype, as well as being a weak antagonist at the α2A and α2B subtypes....
(also weak antagonist at α2A and α2B)
Antagonists
- JP-1302: selective over α2A, α2B, α2D
- spiroxatrineSpiroxatrineSpiroxatrine is drug which acts as a selective antagonist at both the 5-HT1A receptor and the α2C adrenergic receptor. It is an analogue of spiperone, and also has some dopamine antagonist effects....
- yohimbineYohimbineYohimbine is an alkaloid with stimulant and aphrodisiac effects found naturally in Pausinystalia yohimbe . It is also found naturally in Rauwolfia serpentina , Alchornea floribunda , along with several other active alkaloids...
derivatives 9 and 10: >43 fold selectivity over α2A, α2B and α1 subtypes - N-{2-[4-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-[1,4]diazepan-1-yl]-ethyl}-2-phenoxy-nicotinamide