Amorolfine
Encyclopedia
Amorolfine is a morpholine antifungal drug
that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol
and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes.
Marketed as Curanail, Loceryl, Locetar, and Odenil, Amorolfine is commonly available in the form of a nail lacquer
, containing 5% Amorolfine as the active ingredient. It is not approved for the treatment of onychomycosis
in the United States or Canada. It is probably the most effective topical solution for the treatment of toenail infections, although 'systemic treatments are more effective. It is safe enough to be offered over the counter to the general public in Australia and the UK (recently re-classified to over the counter status) and is approved for the treatment of toenail fungus in other countries but requires a prescription.
Amorolfine 5% nail lacquer in once-weekly or twice-weekly applications has been shown in two studies to be between 60% and 71% effective in treating toenail onychomycosis; complete cure rates three months after stopping treatment (after six months of treatment) were 38% and 46%. However, full experimental details of these trials were not available and since they were first reported in 1992 there have been no subsequent trials.
Antifungal drug
An antifungal medication is a medication used to treat fungal infections such as athlete's foot, ringworm, candidiasis , serious systemic infections such as cryptococcal meningitis, and others...
that inhibits D14 reductase and D7-D8 isomerase, which depletes ergosterol
Ergosterol
Ergosterol is a sterol found in fungi, and named for ergot, a common name for the members of the fungal genus Claviceps from which ergosterol was first isolated. Ergosterol does not occur in plant or animal cells...
and causes ignosterol to accumulate in the fungal cytoplasmic cell membranes.
Marketed as Curanail, Loceryl, Locetar, and Odenil, Amorolfine is commonly available in the form of a nail lacquer
Nail polish
Nail polish, or nail varnish, is a lacquer applied to human fingernails or toenails to decorate and/or protect the nail plate.-History:...
, containing 5% Amorolfine as the active ingredient. It is not approved for the treatment of onychomycosis
Onychomycosis
Onychomycosis means fungal infection of the nail. It is the most common disease of the nails and constitutes about a half of all nail abnormalities....
in the United States or Canada. It is probably the most effective topical solution for the treatment of toenail infections, although 'systemic treatments are more effective. It is safe enough to be offered over the counter to the general public in Australia and the UK (recently re-classified to over the counter status) and is approved for the treatment of toenail fungus in other countries but requires a prescription.
Amorolfine 5% nail lacquer in once-weekly or twice-weekly applications has been shown in two studies to be between 60% and 71% effective in treating toenail onychomycosis; complete cure rates three months after stopping treatment (after six months of treatment) were 38% and 46%. However, full experimental details of these trials were not available and since they were first reported in 1992 there have been no subsequent trials.