Anti-IL-6 chimeric monoclonal antibody
Encyclopedia
CNTO 328 is a chimeric (made from human and mouse
proteins) monoclonal antibody being studied in the treatment of advanced kidney cancer
and other types of cancer
.
Anti-IL-6 chimeric monoclonal antibody
works by inhibiting interleukin-6 (IL-6) to reduce inflammation
and tumor
growth. It binds to IL-6 preventing IL-6 activating IL-6 receptors.
It has undergone a phase I clinical trial in Patients With B-Cell Non-Hodgkin's Lymphoma, Multiple Myeloma, or Castleman's Disease.
It gave encouraging results in a small trial for advanced ovarian cancer
.
Encouraging results have been reported from a phase II trial for relapsed or refractory multiple myeloma
.
Mouse
A mouse is a small mammal belonging to the order of rodents. The best known mouse species is the common house mouse . It is also a popular pet. In some places, certain kinds of field mice are also common. This rodent is eaten by large birds such as hawks and eagles...
proteins) monoclonal antibody being studied in the treatment of advanced kidney cancer
Kidney cancer
Kidney cancer is a type of cancer that starts in the cells in the kidney.The two most common types of kidney cancer are renal cell carcinoma and urothelial cell carcinoma of the renal pelvis...
and other types of cancer
Cancer
Cancer , known medically as a malignant neoplasm, is a large group of different diseases, all involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the...
.
Anti-IL-6 chimeric monoclonal antibody
Antibody
An antibody, also known as an immunoglobulin, is a large Y-shaped protein used by the immune system to identify and neutralize foreign objects such as bacteria and viruses. The antibody recognizes a unique part of the foreign target, termed an antigen...
works by inhibiting interleukin-6 (IL-6) to reduce inflammation
Inflammation
Inflammation is part of the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. Inflammation is a protective attempt by the organism to remove the injurious stimuli and to initiate the healing process...
and tumor
Tumor
A tumor or tumour is commonly used as a synonym for a neoplasm that appears enlarged in size. Tumor is not synonymous with cancer...
growth. It binds to IL-6 preventing IL-6 activating IL-6 receptors.
It has undergone a phase I clinical trial in Patients With B-Cell Non-Hodgkin's Lymphoma, Multiple Myeloma, or Castleman's Disease.
It gave encouraging results in a small trial for advanced ovarian cancer
Ovarian cancer
Ovarian cancer is a cancerous growth arising from the ovary. Symptoms are frequently very subtle early on and may include: bloating, pelvic pain, difficulty eating and frequent urination, and are easily confused with other illnesses....
.
Encouraging results have been reported from a phase II trial for relapsed or refractory multiple myeloma
Multiple myeloma
Multiple myeloma , also known as plasma cell myeloma or Kahler's disease , is a cancer of plasma cells, a type of white blood cell normally responsible for the production of antibodies...
.
Further reading
External links
- Anti-IL-6 chimeric monoclonal antibody entry in the public domain NCI Dictionary of Cancer Terms