Anti-apoptotic Ras signalling cascade
Encyclopedia
The Anti-apoptotic Ras signalling cascade is an intracellular signal transduction
cascade
that involves the Ras protein and inhibits apoptosis
. It is the target of the cancer drug gefitinib
.
It may refer to the PI3K/AKT
pathway
.
It may refer to the MAPK/ERK pathway
which involves ras and can affect apoptosis.
The anti-apoptotic STAT
pathway does not involve Ras.
Signal transduction
Signal transduction occurs when an extracellular signaling molecule activates a cell surface receptor. In turn, this receptor alters intracellular molecules creating a response...
cascade
that involves the Ras protein and inhibits apoptosis
Apoptosis
Apoptosis is the process of programmed cell death that may occur in multicellular organisms. Biochemical events lead to characteristic cell changes and death. These changes include blebbing, cell shrinkage, nuclear fragmentation, chromatin condensation, and chromosomal DNA fragmentation...
. It is the target of the cancer drug gefitinib
Gefitinib
Gefitinib INN , trade name Iressa, is a drug used in the treatment of certain types of cancer, particularly those with mutated and overactive EGFR. Gefitinib is an EGFR inhibitor, like erlotinib, which interrupts signaling through the epidermal growth factor receptor in target cells...
.
It may refer to the PI3K/AKT
AKT
Akt, also known as Protein Kinase B , is a serine/threonine protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, cell proliferation, apoptosis, transcription and cell migration.-Family members:...
pathway
.
It may refer to the MAPK/ERK pathway
MAPK/ERK pathway
The MAPK/ERK pathway is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in the nucleus of the cell. The signal starts when a growth factor binds to the receptor on the cell surface and ends when the DNA in the nucleus expresses a...
which involves ras and can affect apoptosis.
The anti-apoptotic STAT
STAT protein
The STAT protein regulates many aspects of growth, survival and differentiation in cells...
pathway does not involve Ras.
External links
- http://www.biocarta.com/pathfiles/h_raspathway.asp Diagram of ras onwards.