Antiestrogen
Encyclopedia
An antiestrogen is a substance that blocks the production or utilization of estrogens, or inhibits their effects. (Estrogens are the family of hormones that promote the development and maintenance
of female
sex characteristics.)
Antiestrogens like tamoxifen
can promote an invasive phenotype in estrogen receptor
(ER)-positive
breast cancer
cells with deficient intercellular adhesion
.
Although aromatase inhibitors could be considered antiestrogens by some definitions, they are often considered to be a distinct class. Aromatase inhibitors reduce the production of estrogen, while the term "antiestrogen" is usually reserved for agents reducing the response to estrogen.
National Collegiate Athletic Association (NCAA) Published list of banned drug for the usage to student-athletes.Examples of anti-estrogens are: anastrozole, clomiphene, tamoxifen, and formestane.
Maintenance of an organism
Maintenance of an organism is the collection of processes to stay alive, excluding production processes.The Dynamic Energy Budget theory delineates two classes...
of female
Female
Female is the sex of an organism, or a part of an organism, which produces non-mobile ova .- Defining characteristics :The ova are defined as the larger gametes in a heterogamous reproduction system, while the smaller, usually motile gamete, the spermatozoon, is produced by the male...
sex characteristics.)
Antiestrogens like tamoxifen
Tamoxifen
Tamoxifen is an antagonist of the estrogen receptor in breast tissue via its active metabolite, hydroxytamoxifen. In other tissues such as the endometrium, it behaves as an agonist, hence tamoxifen may be characterized as a mixed agonist/antagonist...
can promote an invasive phenotype in estrogen receptor
Estrogen receptor
Estrogen receptor refers to a group of receptors that are activated by the hormone 17β-estradiol . Two types of estrogen receptor exist: ER, which is a member of the nuclear hormone family of intracellular receptors, and the estrogen G protein-coupled receptor GPR30 , which is a G protein-coupled...
(ER)-positive
Breast cancer classification
Breast cancer classification divides breast cancer into several categories according to multiple different schemes, each based on different criteria and serving a different purpose. A typical description usually considers each of these aspects in turn: the histolopathological type, the grade of the...
breast cancer
Breast cancer
Breast cancer is cancer originating from breast tissue, most commonly from the inner lining of milk ducts or the lobules that supply the ducts with milk. Cancers originating from ducts are known as ductal carcinomas; those originating from lobules are known as lobular carcinomas...
cells with deficient intercellular adhesion
Cell adhesion
Cellular adhesion is the binding of a cell to a surface, extracellular matrix or another cell using cell adhesion molecules such as selectins, integrins, and cadherins. Correct cellular adhesion is essential in maintaining multicellular structure...
.
Although aromatase inhibitors could be considered antiestrogens by some definitions, they are often considered to be a distinct class. Aromatase inhibitors reduce the production of estrogen, while the term "antiestrogen" is usually reserved for agents reducing the response to estrogen.
See also
- Selective estrogen receptor modulatorSelective estrogen receptor modulatorSelective Estrogen Receptor Modulators are a class of compounds that act on the estrogen receptor. A characteristic that distinguishes these substances from pure receptor agonists and antagonists is that their action is different in various tissues, thereby granting the possibility to selectively...
National Collegiate Athletic Association (NCAA) Published list of banned drug for the usage to student-athletes.Examples of anti-estrogens are: anastrozole, clomiphene, tamoxifen, and formestane.