Arnold J. Levine
Encyclopedia
Arnold J. Levine, is a United States
Molecular biologist. He was awarded the 1998 Louisa Gross Horwitz Prize for Biology or Biochemistry and was thefirst recipient of the Albany Medical Center Prize in Medicine and Biomedical Research in 2001 for his discovery of the tumor suppressor protein p53
. He is past President of Rockefeller University
and currently Professor of Systems Biology at Institute for Advanced Study
in Princeton New Jersey.
tumor suppressor gene
in 1979, a protein involved in cell cycle
regulation, and one of the most frequently mutated genes in human cancer, in work done as a Professor in the biochemistry department at Princeton University
. In 1979 Levine moved to become Chairman of the Department of Microbiology at Stony Brook School of Medicine before moving back to Princeton in 1984. In 1998 Levine became the Robert and Harriet Heilbrunn Professor of Cancer Biology and President of Rockefeller University
. In 2002 he moved to the Robert Wood Johnson Medical School
and in 2004 added a joint appointment as Professor at the Institute for Advanced Study
.
in 1991, and a Member of the Institute of Medicine
of the National Academy of Sciences in 1995. He won t5he Ciba-Drew Award
in 1995. The importance of p53 in cancer biology led to a number of cancer-related awards, including the Bristol-Myers Squibb Award for Distinguished Achievement in Cancer Research (1994), the Charles S. Mott Prize
from the General Motors Cancer Research Foundation (1999), the Keio medical science prize
(2000).
United States
The United States of America is a federal constitutional republic comprising fifty states and a federal district...
Molecular biologist. He was awarded the 1998 Louisa Gross Horwitz Prize for Biology or Biochemistry and was thefirst recipient of the Albany Medical Center Prize in Medicine and Biomedical Research in 2001 for his discovery of the tumor suppressor protein p53
P53
p53 , is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressor that is involved in preventing cancer...
. He is past President of Rockefeller University
Rockefeller University
The Rockefeller University is a private university offering postgraduate and postdoctoral education. It has a strong concentration in the biological sciences. It is also known for producing numerous Nobel laureates...
and currently Professor of Systems Biology at Institute for Advanced Study
Institute for Advanced Study
The Institute for Advanced Study, located in Princeton, New Jersey, United States, is an independent postgraduate center for theoretical research and intellectual inquiry. It was founded in 1930 by Abraham Flexner...
in Princeton New Jersey.
Career
Levine discovered, with several colleagues, the p53P53
p53 , is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressor that is involved in preventing cancer...
tumor suppressor gene
Tumor suppressor gene
A tumor suppressor gene, or anti-oncogene, is a gene that protects a cell from one step on the path to cancer. When this gene is mutated to cause a loss or reduction in its function, the cell can progress to cancer, usually in combination with other genetic changes.-Two-hit hypothesis:Unlike...
in 1979, a protein involved in cell cycle
Cell cycle
The cell cycle, or cell-division cycle, is the series of events that takes place in a cell leading to its division and duplication . In cells without a nucleus , the cell cycle occurs via a process termed binary fission...
regulation, and one of the most frequently mutated genes in human cancer, in work done as a Professor in the biochemistry department at Princeton University
Princeton University
Princeton University is a private research university located in Princeton, New Jersey, United States. The school is one of the eight universities of the Ivy League, and is one of the nine Colonial Colleges founded before the American Revolution....
. In 1979 Levine moved to become Chairman of the Department of Microbiology at Stony Brook School of Medicine before moving back to Princeton in 1984. In 1998 Levine became the Robert and Harriet Heilbrunn Professor of Cancer Biology and President of Rockefeller University
Rockefeller University
The Rockefeller University is a private university offering postgraduate and postdoctoral education. It has a strong concentration in the biological sciences. It is also known for producing numerous Nobel laureates...
. In 2002 he moved to the Robert Wood Johnson Medical School
Robert Wood Johnson Medical School
Robert Wood Johnson Medical School is a public medical school located in Piscataway and New Brunswick, New Jersey, and one of the eight schools of the University of Medicine and Dentistry of New Jersey . In cooperation with Robert Wood Johnson University Hospital, the medical school’s principal...
and in 2004 added a joint appointment as Professor at the Institute for Advanced Study
Institute for Advanced Study
The Institute for Advanced Study, located in Princeton, New Jersey, United States, is an independent postgraduate center for theoretical research and intellectual inquiry. It was founded in 1930 by Abraham Flexner...
.
Award and honors
In addition to the Louisa Gross Horwitz Prize and Albany Prize Levine has received numerous awards and honors. He was elected a Member of the National Academy of SciencesUnited States National Academy of Sciences
The National Academy of Sciences is a corporation in the United States whose members serve pro bono as "advisers to the nation on science, engineering, and medicine." As a national academy, new members of the organization are elected annually by current members, based on their distinguished and...
in 1991, and a Member of the Institute of Medicine
Institute of Medicine
The Institute of Medicine is a not-for-profit, non-governmental American organization founded in 1970, under the congressional charter of the National Academy of Sciences...
of the National Academy of Sciences in 1995. He won t5he Ciba-Drew Award
Ciba-Drew Award
The Ciba-Drew Award for Biomedical Research is an award jointly presented by Ciba-Geigy and Drew University.-Winners:*1995: Joseph Schlessinger and Arnold J. Levine*1992: Stuart L. Schreiber*1990: Roger David Kornberg*1985: Jean-Pierre Changeux...
in 1995. The importance of p53 in cancer biology led to a number of cancer-related awards, including the Bristol-Myers Squibb Award for Distinguished Achievement in Cancer Research (1994), the Charles S. Mott Prize
Charles S. Mott Prize
The $250,000 Charles S. Mott Prize was awarded annually by the General Motors Cancer Research Foundation. The Mott Prize was one of a trio scientific prizes entirely devoted to cancer research . They were generally considered the most prestigious awards in cancer research...
from the General Motors Cancer Research Foundation (1999), the Keio medical science prize
Keio Medical Science Prize
The Keio Medical Science Prize , is a distinguished Japanese prize in medical sciences.-Introduction:The prize is awarded to scientists who made significant contributions to the field of medical sciences or life sciences...
(2000).
External links
- Arnold Levine CV http://www.sns.ias.edu/~alevine/AJLevine_CV.pdf