BANK1 is a gene that encodes a B-cell-specific scaffold protein and tyrosine kinase

Tyrosine kinase

A tyrosine kinase is an enzyme that can transfer a phosphate group from ATP to a protein in a cell. It functions as an "on" or "off" switch in many cellular functions....

 substrate that promotes tyrosine

Tyrosine

Tyrosine or 4-hydroxyphenylalanine, is one of the 22 amino acids that are used by cells to synthesize proteins. Its codons are UAC and UAU. It is a non-essential amino acid with a polar side group...

 phosphorylation of inositol 1,4,5-trisphosphate receptors.

Genomics

The gene is located on the long arm of chromosome 4 (4q24) on the Watson (plus) strand and is 284,206 bases in length. The gene encodes a protein of 785 amino acids (molecular weight 89.335 kDa) and four isoforms are known. The gene is expressed in B-cell but not T-cell or myeloid cell lines. The greatest expression is in CD19(+) B-cells with very low expression in other cell populations.

Function

It is involved in B-cell receptor induced Ca2+ mobilization from intracellular stores and promotes Lyn

Lyn

Lyn may refer to:A surname, variant of LynnIn television and film:* Euros Lyn, Welsh director for television* Lyn Ashley, Australian actress who worked in the United Kingdom on television during the 1960s...

-mediated phosphorylation of IP3 receptors 1 and 2.